Targeting Amastigote and Trypomastigote Phases: Multi-Epitope Vaccine Strategy Against Trypanosoma cruzi [0.03%]
针对阿米巴阶段和浆细胞样阶段的靶向作用：针对克鲁兹锥虫的多表位疫苗策略
Maria Karolaynne da Silva,Caio Patrício de Souza Sena,Davi Serradella Vieira et al.
Maria Karolaynne da Silva et al.
Effective vaccines against Trypanosoma cruzi, the causative agent of Chagas disease, are urgently needed. Here, we report the design and in silico validation of a novel multiepitope vaccine construct targeting the key surface proteins ASP-2...
Novel Inhibitors Targeting Class B1 Metallo-β-Lactamases in Carbapenem-Resistant Acinetobacter baumannii [0.03%]
新型靶向碳青霉烯耐药鲍曼不动杆菌B1类金属β-内酰胺酶的抑制剂
Mohanraj Gopikrishnan,George Priya Doss C
Mohanraj Gopikrishnan
The rise of multidrug resistance (MDR) in Acinetobacter baumannii has severely compromised the efficacy of carbapenem antibiotics. This resistance is primarily driven by class B1 metallo-β-lactamases (MBLs), including IMP, VIM, and NDM, wh...
Formulation of PLA/Chitosan Copolymeric Nanocarriers Enhanced the Sustained and Targeted Drug Delivery of Cinnamic Acid: In Vitro Drug Optimization and In Vivo Biodistribution in Rat Model [0.03%]
聚乳酸/壳聚糖共聚纳米载体的制备可增强肉桂酸的持续和靶向递送：体外药物优化及大鼠模型中的体内生物分布研究
Renuka Mani,Saranya Kannan,Kaviya Panner et al.
Renuka Mani et al.
Polymeric nanoparticles have emerged as attractive carriers for cancer therapies and brain-related disorders due to their increased permeability and retention (EPR) effect. Cinnamic acid (CA), a multifunctional bioactive molecule with notab...
Enhanced Hypoglycemic Activity of Metformin with the Reduction of the Particle Size [0.03%]
通过降低粒径增强二甲双胍的降糖活性
Moupiya Ghosh,Sayantan Pradhan,Sanjukta Dasgupta et al.
Moupiya Ghosh et al.
The particle size of the antihyperglycemic drug metformin has been reduced to the nano range. The structural and microstructural characterizations of pure metformin and nano-metformin have been carried out by the Rietveld refinement of the ...
Waste to Wealth: Tamarind Seed Dietary Fiber as a Potent Prebiotic Feed Additive [0.03%]
变废为宝：用扁桃仁果壳生产有价值的活性炭产品
Balaji Arumugam,Ranjita S Das,Shweta Deotale et al.
Balaji Arumugam et al.
Tamarind (Tamarindus indica) seeds, often discarded as agro-industrial waste, are a rich source of bioactive compounds and dietary fibers. In this study, tamarind seed powder (TSP) was enzymatically treated for 4 h (e4TSP), 6 h (e6TSP), and...
Immunoinformatics-Based Design of a Multi-Epitope Vaccine Targeting a Conserved Copper-Associated Protein in Neisseria gonorrhoeae [0.03%]
基于免疫信息学的多重表位疫苗的设计：针对铜绿假单胞菌中一种保守型金属蛋白的疫苗设计
Sinethemba H Yakobi,Uchechukwu U Nwodo
Sinethemba H Yakobi
Neisseria gonorrhoeae poses an urgent public health challenge due to rapidly increasing antimicrobial resistance and the absence of an effective vaccine. Targeting conserved bacterial pathways involved in essential physiological processes m...
Phytocomponents Derived From Naturally Growing Chamaedorea seifrizii as Novel α-Amylase Inhibitors for Diabetes Management: In Vitro and In Silico Approach [0.03%]
一种新的治疗糖尿病的植物成分：在体外和分子水平上从天然生长的Chamaedoreaseifrizii中获得α-淀粉酶抑制剂
Amrita Chauhan,Arun Dev Sharma,Inderjeet Kaur et al.
Amrita Chauhan et al.
Blocking the enzyme alpha-amylase is a promising approach for treating Type 2 diabetes. Although they have been employed as blood-sugar reducers, medicinal phytocompounds have limited ability to inhibit α-amylase. The bamboo plant Chamaedo...
Simeng Zhang,Xiaoyi Wang,Wei Chen et al.
Simeng Zhang et al.
Indigo, a historically significant blue dye widely used in textiles such as denim, was originally derived from plants. However, traditional extraction faced issues like low yield and high land use, while later chemical synthesis relied on t...
Immunogenicity, Pharmaceutics, and Properties of Recombinant Aspergillus flavus Uricase Modified by Citric Acid/Ethylenediamine Carbon Dots [0.03%]
柠檬酸/乙二胺碳点修饰的重组曲霉尿酸酶的免疫原性、药剂学及理化性质研究
Hai-Ling Li,Hong-Bin Jia,Jin-Long He et al.
Hai-Ling Li et al.
Clinically, patients with gout are often treated with uricase (Uox)-based drugs. While these medications are effective, many patients suffer from immune rejection associated with their use. To reduce Uox's immunogenicity, it was modified wi...
Preparation and Characterization of PVA-SA Hydrogel Immobilized β-Galactosidase With Improved Catalytic Properties [0.03%]
一种固定β-半乳糖苷酶的PVA-SA水凝胶及其性能研究
Doruk Akdoğan,Ayşegül Peksel
Doruk Akdoğan
This study reports the immobilization of Aspergillus oryzae β-galactosidase in a polyvinyl alcohol-sodium alginate (PVA-SA) hydrogel and its performance compared with the free enzyme. Through immobilization, the optimum temperature shifted...