Preliminary Assessment of Cytotoxic Effects of Murraya koenigii Toluene Extracts on PA1 Cells via LC-MS, In Vitro, and In Silico Approaches [0.03%]
莱鲍迪甘菊素体外细胞毒性效应的初步评估——基于LC-MS、体内和计算机模拟的方法
Shubham Hajare,Tanvi Patade,Jayshri Shrimangale et al.
Shubham Hajare et al.
Murraya koenigii (MK) is a medicinal plant known for its diverse phytochemical constituents and therapeutic properties. This study presents the first comprehensive analysis of MK leaf and stem whole extracts obtained using toluene, a non-po...
Dual Inhibition of AChE and GST by 1,2,4-Triazine-3-Amine: Integrated Biochemical, Computational, and Hepatotoxicity Insights [0.03%]
三胺茋类衍生物的AChE/GST双靶抑制作用：生化、计算及肝毒性研究
Ercan Oguz,Gizem Sertkaya Tulek,Elsevar Asadove et al.
Ercan Oguz et al.
1,2,4-Triazine-3-amines (TzAs) are a group of compounds having a triazine ring and generally have a heterocyclic structure containing three nitrogen atoms. Studies have revealed that these compounds may exhibit antitumor, antimicrobial, ant...
Correlation of Differential Gene Expression and Clinical Variations in Hypertrophic Cardiomyopathy via Whole Genome Sequencing [0.03%]
全基因组测序在肥厚型心肌病中的应用：基因表达差异与临床表型相关性分析
Prashantha Cn,Ramachandra R,Guruprasad Nm et al.
Prashantha Cn et al.
Hypertrophic cardiomyopathy (HCM) is a prevalent cardiovascular disorder affecting populations worldwide, characterized by abnormal thickening of the heart muscle.(Supporting S1) The development of HCM is influenced by multiple factors, inc...
Antiproliferative and Apoptotic Effects of Lavandula officinalis In Vitro by Inhibiting HeLa Cancer Cell Growth and Migration [0.03%]
牻牛儿菊酯诱导人宫颈癌HeLa细胞凋亡及其机制研究
Abdulwahab Ali Abuderman,Musthaq Ahmed Mohamed,Faziljon Rasulov et al.
Abdulwahab Ali Abuderman et al.
The most prevalent cancer in women is cervical cancer, which is impacted by lifestyle choices, inadequate healthcare, and HPV exposure. The medicinal qualities of lavender, or Lavandula officinalis, include antibacterial, anti-inflammatory,...
Systems Biology Approach to Berberine Metabolomics and Toxicity: An In Silico Investigation of Bioactive Pathways and Risk Assessment [0.03%]
小檗碱代谢组学及毒理学的系统生物学方法——生物活性途径的计算风险评估研究
Suranjana Sarkar,Debanshu Sharma,Sutrishna Manna et al.
Suranjana Sarkar et al.
Berberine, a bioactive isoquinoline alkaloid found in various medicinal plants, has gained special attention for its bioactive properties, including antimicrobial, anti-inflammatory, and anticancer activities. However, for safe and therapeu...
5-Aminoimidazole-4-carboxamide-1- [Formula: see text] -d-ribofuranoside ameliorates lipotoxicity through enhanced reticulophagy in HepG2 cells [0.03%]
5-氨基咪唑-4-甲酰胺-1-[公式]-D-核糖呋喃糖苷通过增强HepG2细胞的网状内质网自噬来改善脂毒性
Ajay Krishnan U,Anuradha Carani Venkataraman,Vidhya Ramachandran
Ajay Krishnan U
Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease arising from the accumulation of lipids in the liver. Autophagy is an organized form of intracellular degradation process that eliminates damaged organelles and proteins. ...
Synthesis, Molecular Structure, and Antibacterial Efficacies of Transition Metal Azo-Oximates of Fe(II) and Mn(II), a Sustainable Solution to Multidrug Resistance in Bacteria [0.03%]
合成、分子结构及抗菌效果研究：铁（II）和锰（II）的过渡金属偶氮肟类化合物，一种应对细菌多重耐药性的可持续解决方案
Aratrika Samajdar,Supriyo Halder,Sukanya Chatterjee et al.
Aratrika Samajdar et al.
Azo-oxime ligands, namely, Ar-HLPh, 1 (Ar = phenyl, pyridyl, and naphthyl) and Ar⁄-HLpy 2 (Ar⁄ = phenyl, p-tolyl) were used to synthesize three trinuclear mixed valence iron complexes of type [FeIII(FeII(Ar-LPh)3)2]ClO4 3+ClO4 - and four ...
Genomic and Functional Characterization of the Phenylalanine Ammonia Lyase (PAL) Gene Family in Wheat (Triticum aestivum) Reveals Roles in Salt Stress Adaptation [0.03%]
利用基因组和功能分析鉴定小麦中的苯氨酶(PAL)基因家族及其在盐胁迫适应性中的作用
Manisha Singh,Shivali Pandita,Sushmita et al.
Manisha Singh et al.
Plant phenylpropanoid metabolism is a crucial process involving phenylalanine ammonia lyase (PAL) enzyme, which is essential for plant growth and development. PAL generates secondary metabolites and also has a significant impact on plant de...
Ameliorative Effect of Melatonin on Morphological and Biochemical Parameters of Salt-Tolerant and Sensitive Genotypes of Macrotyloma Uniflorum (L.) Verdc [0.03%]
褪黑素对Macrotyloma uniflorum(L.)Verdc盐胁迫耐受和敏感基因型形态及生化参数改善效果的影响
Vasudha Maurya,Narayan Singh,Ashutosh Sharma et al.
Vasudha Maurya et al.
Salt stress is a major challenge to the production of legumes as it affects their germination, growth, yield, and general physiology. Further, it also impairs their nitrogen fixation by causing osmotic stress and sodium-induced nutrient imb...
Huiyi Zeng,Dandan Li,Yunyi Li et al.
Huiyi Zeng et al.
Minimal change disease (MCD) is a glomerular disorder, which is the most common cause of nephrotic syndrome in children. Additionally, the prevalence of MCD in adults has been increasing in recent years. During protein synthesis, noncoding ...