Development and Validation of an ELISA Method for Quantification of HuB01 in Fermentation Products [0.03%]
一种用于发酵产品中HuB01定量的ELISA方法的开发与验证
Yuying Liu,Yao Zhang,Ling Li et al.
Yuying Liu et al.
Background: The antibodies (including 7C4, 8D1) are neutralizing antibodies specifically targeting the protein RBD, a key core of the combination with angiotensin-converting enzyme 2 (ACE2). In order to measure HuB01 in f...
Optimization and Characterization of Poly-γ-Glutamic Acid Production From a Locally Isolated Bacillus cereus ARM24 [0.03%]
一株当地分离的Bacillus cereus ARM24产聚谷氨酸条件优化及其产物性质分析
Mohammed Jabbar Hafiz Al-Wahili,Alaa Jabbar Abd Al-Manhel,Rawdah Mahmood Al-Ali et al.
Mohammed Jabbar Hafiz Al-Wahili et al.
For identification of this new local poly-γ-glutamic acid (γ-PGA) bacteria and partial purification of γ-PGA, the bacterium was studied and identified as Bacillus cereus. Sixty isolates of Bacillus spp. were collected from 28 sources (ag...
Isolation and Characterization of a Novel Microbacterium takaoensis Lipase for Nutritional and Textural Improvement of Pizza Dough [0.03%]
一种新型微细菌脂酶的分离与表征及其在改善披萨饼底营养和质构方面的应用研究
Hetsi Goswami,Ashok Kumar Bishoyi,Gaurav Sanghvi
Hetsi Goswami
Lipases are industrially important enzymes with broad applications in food processing, particularly in enhancing dough quality. In the current work, a lipase-producing strain was collected from oil-contaminated soil and recognized as Microb...
Targeting Amastigote and Trypomastigote Phases: Multi-Epitope Vaccine Strategy Against Trypanosoma cruzi [0.03%]
针对阿米巴阶段和浆细胞样阶段的靶向作用：针对克鲁兹锥虫的多表位疫苗策略
Maria Karolaynne da Silva,Caio Patrício de Souza Sena,Davi Serradella Vieira et al.
Maria Karolaynne da Silva et al.
Effective vaccines against Trypanosoma cruzi, the causative agent of Chagas disease, are urgently needed. Here, we report the design and in silico validation of a novel multiepitope vaccine construct targeting the key surface proteins ASP-2...
Novel Inhibitors Targeting Class B1 Metallo-β-Lactamases in Carbapenem-Resistant Acinetobacter baumannii [0.03%]
新型靶向碳青霉烯耐药鲍曼不动杆菌B1类金属β-内酰胺酶的抑制剂
Mohanraj Gopikrishnan,George Priya Doss C
Mohanraj Gopikrishnan
The rise of multidrug resistance (MDR) in Acinetobacter baumannii has severely compromised the efficacy of carbapenem antibiotics. This resistance is primarily driven by class B1 metallo-β-lactamases (MBLs), including IMP, VIM, and NDM, wh...
Formulation of PLA/Chitosan Copolymeric Nanocarriers Enhanced the Sustained and Targeted Drug Delivery of Cinnamic Acid: In Vitro Drug Optimization and In Vivo Biodistribution in Rat Model [0.03%]
聚乳酸/壳聚糖共聚纳米载体的制备可增强肉桂酸的持续和靶向递送：体外药物优化及大鼠模型中的体内生物分布研究
Renuka Mani,Saranya Kannan,Kaviya Panner et al.
Renuka Mani et al.
Polymeric nanoparticles have emerged as attractive carriers for cancer therapies and brain-related disorders due to their increased permeability and retention (EPR) effect. Cinnamic acid (CA), a multifunctional bioactive molecule with notab...
Enhanced Hypoglycemic Activity of Metformin with the Reduction of the Particle Size [0.03%]
通过降低粒径增强二甲双胍的降糖活性
Moupiya Ghosh,Sayantan Pradhan,Sanjukta Dasgupta et al.
Moupiya Ghosh et al.
The particle size of the antihyperglycemic drug metformin has been reduced to the nano range. The structural and microstructural characterizations of pure metformin and nano-metformin have been carried out by the Rietveld refinement of the ...
Waste to Wealth: Tamarind Seed Dietary Fiber as a Potent Prebiotic Feed Additive [0.03%]
变废为宝：用扁桃仁果壳生产有价值的活性炭产品
Balaji Arumugam,Ranjita S Das,Shweta Deotale et al.
Balaji Arumugam et al.
Tamarind (Tamarindus indica) seeds, often discarded as agro-industrial waste, are a rich source of bioactive compounds and dietary fibers. In this study, tamarind seed powder (TSP) was enzymatically treated for 4 h (e4TSP), 6 h (e6TSP), and...
Immunoinformatics-Based Design of a Multi-Epitope Vaccine Targeting a Conserved Copper-Associated Protein in Neisseria gonorrhoeae [0.03%]
基于免疫信息学的多重表位疫苗的设计：针对铜绿假单胞菌中一种保守型金属蛋白的疫苗设计
Sinethemba H Yakobi,Uchechukwu U Nwodo
Sinethemba H Yakobi
Neisseria gonorrhoeae poses an urgent public health challenge due to rapidly increasing antimicrobial resistance and the absence of an effective vaccine. Targeting conserved bacterial pathways involved in essential physiological processes m...
Phytocomponents Derived From Naturally Growing Chamaedorea seifrizii as Novel α-Amylase Inhibitors for Diabetes Management: In Vitro and In Silico Approach [0.03%]
一种新的治疗糖尿病的植物成分：在体外和分子水平上从天然生长的Chamaedoreaseifrizii中获得α-淀粉酶抑制剂
Amrita Chauhan,Arun Dev Sharma,Inderjeet Kaur et al.
Amrita Chauhan et al.
Blocking the enzyme alpha-amylase is a promising approach for treating Type 2 diabetes. Although they have been employed as blood-sugar reducers, medicinal phytocompounds have limited ability to inhibit α-amylase. The bamboo plant Chamaedo...