Dapagliflozin regulates autophagy in nephropathy associated with non-diabetic obesity via elevated plasma β-hydroxybutyrate levels [0.03%]
达格列净通过提高血浆β-羟基丁酸水平调节与非糖尿病肥胖相关的肾病的自噬作用
Yan Kong,Xiaoyue Peng,Wenying Fan et al.
Yan Kong et al.
Obesity is a major contributor to chronic kidney disease, accounting for approximately 20%-25% of cases globally. In obesity-related kidney disease (OKD), ectopic lipid accumulation in renal proximal tubule cells impairs autophagic flux, ex...
Nuclear Translocation of Mitochondrial Ferredoxin Reductase Is Regulated by AKT-Mediated Phosphorylation [0.03%]
Akt介导的磷酸化调控线粒体铁氧还蛋白氧化还原酶的核转位
Jin Zhang,Ken-Ichi Nakajima,Shakur Mohibi et al.
Jin Zhang et al.
Ferredoxin reductase (FDXR) is the sole ferredoxin reductase in humans and plays an essential role for steroidogenesis and biosynthesis of heme and iron sulfur cluster (ISC) by transferring electrons from NADPH to ISC-containing ferredoxin ...
Modulating backbone flexibility in hydroxamate siderophores for improved iron chelation and peptide nucleic acid (PNA) delivery into bacteria [0.03%]
通过调节羟胺 siderophores 背骨的柔韧性以提高其铁螯合能力及肽核酸(PNA)在细菌中的导入性能
Uladzislava Tsylents,Piotr Maj,Mateusz Wdowiak et al.
Uladzislava Tsylents et al.
The development of effective delivery systems for peptide nucleic acids (PNAs) into bacterial cells remains a critical challenge in antisense therapeutics. We report the design and evaluation of hydroxamate siderophore-PNA conjugates that e...
Towards broad-spectrum antiviral drugs: inhibition of transmembrane serine proteases [0.03%]
广谱抗病毒药物的研究进展：跨膜丝氨酸蛋白酶的抑制作用
Victoria Banas,Michael P Mannino,James W Janetka
Victoria Banas
Proteases are important for the pathogenesis of many viruses. These proteolytic enzymes cleave one or more amide bonds of viral proteins. This protein processing is required for viral entry and replication. The most widely utilized for this...
Modulation of Nur77-DNA interactions by the glucocorticoid receptor [0.03%]
糖皮质激素受体对Nur77-DNA相互作用的调节
Laurens W H J Heling,Kristina Kovač,Carlie J M de Vries et al.
Laurens W H J Heling et al.
Nuclear receptors (NRs) comprise a superfamily of (ligand-)regulated transcription factors that are pivotal in orchestrating gene networks essential for development, metabolism, and cellular homeostasis. Their activity is critical for norma...
Inducing TRIB2 Targeted Protein Degradation to Reverse Chemoresistance in Acute Myeloid Leukaemia [0.03%]
通过诱发TRIB2靶向蛋白降解逆转急性髓系白血病化疗耐药性
Evie Rigby,Francesca Fasanella Masci,Akshara Narayanan et al.
Evie Rigby et al.
The myeloid oncogene TRIB2 is a key driver of acute myeloid leukaemia (AML) pathogenesis, promoting chemoresistance and blocking differentiation through ubiquitin-mediated degradation of the C/EBPα transcription factor. Despite its stable ...
Artemether and Euphorbia Factor L9 suppress kynurenine production through distinct effects on Tryptophan metabolism [0.03%]
青蒿素和大戟因子L9通过不同的机制抑制犬尿氨酸的生成
Alina L Capatina,Tomasz Czechowski,Charlotte Plunkett-Jones et al.
Alina L Capatina et al.
L-Tryptophan (Trp) is an essential amino acid, catabolised through the kynurenine pathway, which is mediated by the enzymes indoleamine-2,3-dioxygenase 1 (IDO1), IDO2, or Trp-2,3-deoxygenase (TDO). In cancer, IDO1 acts as an immune checkpoi...
Structural and mechanistic basis of mTORC2 activation of protein kinase AKT/PKB [0.03%]
mTORC2激活蛋白激酶AKT/PKB的结构和机制基础
Nam Chu,Nhat Le,Ouada Nebie et al.
Nam Chu et al.
The PI3K/AKT/mTOR signaling pathway is crucial for regulating essential cellular processes such as growth, survival, metabolism, and protein synthesis. Dysregulation of this pathway is strongly associated with diseases like cancer, where it...
Excretory-secretory products of the fish-borne parasite Anisakis simplex L3 larvae possess allergens and unusual glycan modifications [0.03%]
鱼寄生虫拟南方家线虫L3幼虫的排泄分泌产物含有过敏原及特殊的糖蛋白糖基化修饰
Isabella Adduci,Xiaoxu Wang,Katharina Paschinger et al.
Isabella Adduci et al.
Anisakis simplex is a parasitic aquatic nematode, which may cause mild-to-severe gastrointestinal allergic reactions (Anisakiasis) with clinical symptoms, such as rhinitis and urticaria in humans who accidentally consume raw or undercooked ...
Docking in the Abies grandis abietaenol synthase to investigate the mechanism underlying conifer resin acid diterpene synthase evolution [0.03%]
对接abies grandis abietaenol合酶以探讨松树树脂酸倍半萜合酶进化机制背后的机理
Mark Schmidt-Dannert,Griffin Humphreys,Taylor Eich et al.
Mark Schmidt-Dannert et al.
The pine family (Pinaceae) produces oleoresins in which the diterpenoid resin acids contain tricyclic backbones of either the (iso)pimarane and/or rearranged abietane type. These are produced by closely related (class I) diterpene synthases...