The role of CYP3A-CYP2E1 interactions in activation of CYP3A enzymes by chronic alcohol exposure [0.03%]
CYP3A与CYP2E1的相互作用在慢性酒精暴露活化CYP3A中的功能分析
Dmitri R Davydov,Kannapiran Ponraj,Nadezhda Y Davydova et al.
Dmitri R Davydov et al.
To examine the effect of chronic alcohol exposure on the activity of CYP3A enzymes in human liver, we studied the metabolism of CYP3A-specific substrates 7-benzyloxyquinoline (7-BQ) and ivermectin in 23 preparations of human liver microsome...
Dynamics of flexible intracellular regions modulate communication and fine-tune pH gating in plant aquaporins [0.03%]
植物水通道蛋白中柔性的胞内区域的动力学调节其通讯并微调其pH门控反应
Agustina Canessa Fortuna,Gerardo Zerbetto De Palma,Rocío Bussolini Lizundia et al.
Agustina Canessa Fortuna et al.
Intracellular pH regulation of PIP2 aquaporins, primarily mediated by a histidine sensor in loop D, is essential for controlling water transport. While the C-terminal domain is involved, the precise contribution of N-terminal and other flex...
Inhibition by ATP regulates the activity of a CBASS anti-phage nucleotide cyclase [0.03%]
ATP抑制调控CBASS抗噬菌体核苷酸cyclase活性
Laura Gaskell-Mew,Stuart McQuarrie,Stephen A McMahon et al.
Laura Gaskell-Mew et al.
The bacterial anti-phage immune system is complex, diverse and in several important cases ancestral to that found in eukaryotes, including humans. One example is CBASS (Cyclic oligonucleotide Based Anti-phage Signalling System), a widesprea...
Structural and mechanistic insights into protein glycosylation and glycosylphosphatidylinositol anchoring in the endoplasmic reticulum membrane [0.03%]
内质网膜中蛋白质糖基化和糖基磷脂酰肌醇锚定的结构和机理见解
David O Harris,Ana S Ramírez
David O Harris
The endoplasmic reticulum (ER) hosts several integral membrane enzymes responsible for post-translational modifications of proteins entering the secretory pathway. These include protein glycosylation and the attachment of glycosylphosphatid...
Christine H Foyer,Robert T Furbank
Christine H Foyer
The discovery of the C4 pathway laid the foundations of a revolution in plant biochemistry. The Hatch and Slack paper published in the Biochemical Journal described a specialized pathway of photosynthetic metabolism that minimizes the loss ...
Expression of Concern: The RNA-binding protein CUG-BP1 increases survivin expression in oesophageal cancer cells through enhanced mRNA stability [0.03%]
表达关注：RNA结合蛋白CUG-BP1通过增强信使核糖核酸稳定性增加食管癌细胞中存活素的表达
Elizabeth T Chang,James M Donahue,Lan Xiao et al.
Elizabeth T Chang et al.
The RNA-binding protein HuR stabilizes survivin mRNA in human oesophageal epithelial cells [0.03%]
RNA结合蛋白HuR稳定人食管上皮细胞 survivin mRNA
James M Donahue,Elizabeth T Chang,Lan Xiao et al.
James M Donahue et al.
Molecular dissection of the Cereibacter sphaeroides spheroidene monooxygenase [0.03%]
裂殖壶菌类红球菌spheroidene单加氧酶的分子解析
Elizabeth C Martin,Karolina O Panas,Felix S Morey-Burrows et al.
Elizabeth C Martin et al.
In some purple phototrophic bacteria, the enzyme spheroidene monooxygenase (CrtA) catalyses the final step of carotenoid biosynthesis, introducing a keto group at the C2 position of spheroidene to produce spheroidenone. CrtA from the model ...
A distinctive PDZ:β-hairpin interaction mediates AFDN complex with SCRIB and promotes binding to KRAS [0.03%]
独特的PDZ:β-发夹相互作用介导AFDN与SCRIB的结合并促进其与KRAS的结合
Chang Hwa Jo,Regina Strakhova,Marilyn Goudreault et al.
Chang Hwa Jo et al.
PDZ domains canonically recognize short C-terminal peptide motifs, but numerous non-canonical binding mechanisms have also been described. We previously identified a direct interaction between the cell polarity protein SCRIB and the RAS eff...
Razeen Shaikh,Caitlin Frank,Nissa J Larson et al.
Razeen Shaikh et al.
The bone-morphogenetic protein (BMP)-SMAD signal transduction pathway regulates fundamental cellular processes such as fate specification, tissue patterning, and stem cell homeostasis across metazoans and has a conserved signaling architect...