Artemether and Euphorbia Factor L9 suppress kynurenine production through distinct effects on Tryptophan metabolism
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L-Tryptophan (Trp) is an essential amino acid, catabolised through the kynurenine pathway, which is mediated by the enzymes indoleamine-2,3-dioxygenase 1 (IDO1), IDO2, or Trp-2,3-deoxygenase (TDO). In cancer, IDO1 acts as an immune checkpoint suppressing effec... ...
