Distinct distributions of myosin motor conformations during contraction of slow and fast skeletal muscle [0.03%]
慢肌和快肌收缩过程中我的蛋白马达构象的分布不同
Cameron Hill,Michaeljohn Kalakoutis,Alice Arcidiacono et al.
Cameron Hill et al.
Slow skeletal muscles maintain posture and produce graded movement at low metabolic cost. ATP utilization during fixed-end contractions is typically five times slower in slow muscles than in fast muscles from the same species. Mechanical me...
TRIP8bnano peptide prevents cAMP binding to HCN2 channels alleviating pain-like behaviors in rats with neuropathic pain [0.03%]
TRIP8b纳米肽可通过阻止环磷酸腺苷与HCN2通道结合来缓解大鼠神经病理性疼痛症状
Santiago I Loya-Lopez,Kimberly Gomez,Alessandro Porro et al.
Santiago I Loya-Lopez et al.
Hyperpolarization-activated cyclic nucleotide-gated 2 (HCN2) channels regulate action potential firing in nociceptors and are critical mediators of neuronal hyperexcitability in response to inflammation and nerve injury. These channels are ...
Steady-state Purkinje cell activity has limited predictive power for cerebellar output in disease [0.03%]
稳态浦肯野细胞活动对疾病状态下小脑输出的预测能力有限
Alyssa M Lyon,Viviana Hernandez-Castanon,Meike E van der Heijden
Alyssa M Lyon
Cerebellar dysfunction can cause ataxia, dystonia, and tremor. Cerebellar nuclei neurons, the main cerebellar output neurons, exhibit distinct spike patterns in mouse models for different movement disorders. However nuclei spike pattern cha...
Exacerbated ATP transmission in the carotid body is linked to glomus cell expansion in spontaneously hypertensive rats [0.03%]
加重的颈动脉体ATP传递与 SHR 胶质细胞扩张相关
Igor S A Felippe,Audrys Pauza,Olivia M S Gold et al.
Igor S A Felippe et al.
ATP acting on P2X3 receptors contributes to carotid body (CB) hyperexcitability in spontaneously hypertensive rats (SHRs). We investigated whether this reflects altered ATP release and/or impaired ATP metabolism. Using in vitro CB preparati...
Rohan M Lewis,Anandita Umapathy,Jane K Cleal et al.
Rohan M Lewis et al.
Understanding how pharmaceuticals cross the placenta is central to balancing effective maternal therapy with fetal safety. Computational and physiologically based pharmacokinetic models are powerful tools for predicting fetal drug exposure,...
From molecule to bedside and back: the integration of computational and experimental physiology in the digital age [0.03%]
从分子到临床再到分子：计算与实验生理学在数字时代的融合
Viviane Timmermann,Axel Loewe
Viviane Timmermann
Editorial
The Journal of physiology. 2026 Apr 17. DOI:10.1113/JP290785 2026
Noise-induced reduction and early recovery of superior paraolivary nucleus sound-offset responses [0.03%]
噪声诱发的上旁橄榄核声音停止反应的减小和早期恢复
Mihai Stancu,Ezhilarasan Rajaram,Joseph A Kroeger et al.
Mihai Stancu et al.
Neural circuits exhibit remarkable plasticity in response to varying intensities of sensory input. The temporal dynamics and cellular mechanisms underlying this plasticity are highly heterogeneous and possibly specific to individual circuit...
The role of extracellular vesicles in cell-cell crosstalk in cardiotoxicity [0.03%]
细胞毒性细胞间交叉谈话中胞外囊泡的作用
Gabriella Bachynskyj-Bilas,Debbie J Otto,Daniel Stratton et al.
Gabriella Bachynskyj-Bilas et al.
Cardiotoxicity can be a result of the action of various therapeutic drugs, including anti-cancer drugs, and can pose a greater risk to patients' health than the underlying disease being treated. As cardiac function relies on the interplay b...