The heart responds to pressure via the lung: Dive depth alters cardiac control in bottlenose dolphins [0.03%]
心脏通过肺对压力作出反应：潜水深度改变了瓶鼻海豚的心脏控制方式
F Cunha Oliveira,N Pelufo Martínez,K Aoki et al.
F Cunha Oliveira et al.
Marine mammals face the dual challenge of foraging underwater while relying on limited oxygen stores, making efficient oxygen management essential for survival. The dive response, which includes bradycardia and peripheral vasoconstriction, ...
Developmental origins of hypertension: The role of neonatal breathing irregularities and hypoxaemia [0.03%]
高血压的发病机制：新生儿呼吸不规律和低氧血症的作用
Michael A Jolly
Michael A Jolly
Adaptations of glucagon-like peptide-1 receptor agonist-induced weight loss, drivers of weight regain and future directions of therapeutics [0.03%]
GLP-1受体激动剂引起的体重减轻的适应性、体重回升的影响因素及未来治疗策略发展方向
Camille E M Piguet,Rosie Nucci,Jacqueline L Beaudry
Camille E M Piguet
Obesity, characterized by excess gain in body fat, alters energy balance and metabolic health. Weight loss is an effective strategy to favourably restore metabolic parameters in obese condition, and this can be achieved through caloric rest...
Old dog, new trick: Charybdotoxin as a novel ryanodine receptor blocker [0.03%]
老狗新招式：Charybdotoxin作为新型ryanodine受体阻断剂
Zsuzsanna Édua Magyar,Judit Hevesi,Frigyes Mészáros et al.
Zsuzsanna Édua Magyar et al.
Ryanodine receptors (RyRs) are Ca2 +-release channels of the sarcoplasmic reticulum. Because uncontrolled Ca2 +-release underlies several muscle and cardiac disorders, pharmacological inhibition of RyRs represents an attractive therapeutic ...
Jia Han,Xiao&#x;ao Xue,Xiaojian Shi et al.
Jia Han et al.
A step beyond the cage: How infradian and circadian research in mice translates to humans [0.03%]
迈向笼子之外：小鼠的亚昼夜节律和昼夜节律研究如何应用于人类
Evan C Ciecko,Raina Lakhani,Vincent C Guarino et al.
Evan C Ciecko et al.
Molecular determinants of functional voltage-gated sodium (Nav) channel diversity in mammalian central neurons [0.03%]
哺乳动物中枢神经元功能电压门控钠通道多样性的分子决定因素
Joseph L Ransdell,Jeanne M Nerbonne
Joseph L Ransdell
Voltage-gated sodium (Nav) channels are key determinants of neuronal excitability, shaping action potential waveforms, repetitive firing patterns and responses to synaptic inputs, as well as controlling the output of neural circuits and inf...
Pain relief but respiratory depression: Insights into the dark side of opioid overuse [0.03%]
止痛却抑制呼吸：阿片类药物滥用的阴暗面透视
Daniel B Zoccal
Daniel B Zoccal
Sedentary ageing remodels the structure-function relationships that underlie calcium signalling at super-resolution scales in the heart [0.03%]
久坐老化重塑心脏钙信号结构功能关系的超分辨率影像学研究
Miriam E Hurley,David Conesa,Alan P Benson et al.
Miriam E Hurley et al.
Intracellular calcium handling underpins excitation-contraction coupling in the heart, and its dysfunction has been linked to both mechanical and electrical impairments. Age-related remodelling of the structure-function relationships that u...