Exploring the Influence of Synaptic Density and Anxiety on Pain Perception: Evidence from a [11C]UCB-J PET Imaging Study [0.03%]
基于[11C]UCB-J正电子发射断层扫描影像研究探索突触密度和焦虑对疼痛感知的影响
Karina Moisieienko,Ruth H Asch,Margaret T Davis et al.
Karina Moisieienko et al.
Background: Structural and functional brain alterations may be associated with pain and anxiety. We hypothesized that synaptic density (measured in vivo with [11C]UCB-J and positron emission tomography quantification of s...
Frequent Vocalizations and DBS-Responsive Hyperkinesia in a Striatal Disinhibition Rat Model for Tourette Syndrome [0.03%]
基于纹状体失抑制的Tourette综合征大鼠模型中的频繁发声和深部脑刺激响应性运动过多症
Boriss Sagalajev,Lina Lennartz,Niloofar Mokhtari et al.
Boriss Sagalajev et al.
Background: The lack of a rodent model for both motor and phonic tics hinders research on deep brain stimulation (DBS) for refractory Tourette syndrome (TS). Striatal disinhibition with a GABA-A antagonist (bicuculline) w...
NMDA Receptor Involvement in Dopaminergic Modulation of Neuroplasticity Induced by Paired Associative Stimulation [0.03%]
N-甲基-D天冬氨酸受体参与paired associative stimulation诱发的多巴胺能调节神经可塑性的作用
Marie C Beaupain,Elham Ghanavati,Amba M Frese et al.
Marie C Beaupain et al.
Background: Dopamine (DA) modulates long-term potentiation (LTP)-like neuroplasticity. While particularly D1 and D2 receptors are thought to influence neuroplasticity through glutamatergic NMDA receptor and GABA modulatio...
Pharmacological modulation of directed network communication and neural hubs in action-effect integration [0.03%]
药理学调制行动效果整合中的定向网络通讯和神经中枢
Jasmin Mayer,Anna Helin Koyun,Moritz Mückschel et al.
Jasmin Mayer et al.
Background: Acting intentionally requires individuals to anticipate the effects of their actions. Recent work has revealed the neural oscillatory dynamics underlying the establishment of action-effect bindings, which are ...
Role of endogenous serotonin in psychedelic-like effects of psilocybin in mice [0.03%]
裸头鬼笔素的致幻作用与内源性血清素的关系研究
I Erkizia-Santamaría,N Martínez-Álvarez,L Salinas-Novoa et al.
I Erkizia-Santamaría et al.
Background: The psychedelic psilocybin has been posited as efficacious for the treatment of depression. However, the potential link between the intensity of acute psychedelic effects and long-term therapeutic outcomes rem...
Acute effects of intranasal esketamine application on thalamic structures in healthy individuals [0.03%]
鼻用艾斯氯胺酮对健康受试者丘脑结构的急性影响
B Spurny-Dworak,T Liebe,S Graf et al.
B Spurny-Dworak et al.
Background: The N-methyl-D-aspartate receptor antagonist ketamine has found broad application in the field of psychiatry. Due to its rapid antidepressant and anti-suicidal properties, it is used as treatment for major dep...
Acute inflammation induced by the Escherichia coli lipopolysaccharide considerably increases the systemic and brain exposure of olanzapine after oral administration in mice [0.03%]
口服给予小鼠后奥氮平的全身和脑暴露量经大肠杆菌脂多糖诱发的急性炎症明显增加
Jan Hubeňák,Martin Mžik,Hana Laštůvková et al.
Jan Hubeňák et al.
Background: A detailed understanding of alterations in olanzapine pharmacokinetics during acute inflammatory states, associated with infections, remains lacking. This study aimed to investigate the impact of endotoxemia o...
Inhibition of Hippocampal or Thalamic Inputs to the Nucleus Accumbens Reverses Stress-induced Alterations in Dopamine System Function [0.03%]
海马或丘脑输入到伏隔核的抑制逆转了压力引起的多巴胺系统功能改变
Hannah B Elam,Alexandra M McCoy,Angela M Boley et al.
Hannah B Elam et al.
Background: Symptoms of psychosis are often observed in patients with post-traumatic stress disorder (PTSD) and are driven by aberrant regulation of the mesolimbic dopamine system. We have previously shown that targeting ...
Exploring the Risk of Adverse Drug Events in Combination with antiparkinsonics and antipsychotics - a two-decade real-world pharmacovigilance analysis based on the FAERS database [0.03%]
基于FAERS数据库的抗帕金森病药物与抗精神病药物联用风险探索——二十年真实世界用药警戒分析
Junyi Wang,Sen Lin,Chen Bai et al.
Junyi Wang et al.
Background: The combination of antiparkinsonics and antipsychotic drugs (AP) can improve the motor and mental symptoms of Parkinson's disease (PD) and reduce the actual burden of chronic disease care. To explore the adver...
Roluperidone monotherapy, a treatment for negative symptoms in schizophrenia [0.03%]
用于治疗精神分裂症阴性症状的 Roluperidone 单药疗法
Michael Davidson,Nadine Noel,Florent Schmitt et al.
Michael Davidson et al.
Roluperidone is a drug in development targeting primary negative symptoms in schizophrenia which binds sigma-2, 5-HT2A and alpha1a receptors. Roluperidone administered as monotherapy to patients suffering from mild to moderate negative symp...