Adjunctive Brexpiprazole in Patients With Unresolved Symptoms of Depression on Antidepressant Treatment Who are Early in the Disease Course: Post Hoc Analysis of Randomized Controlled Trials [0.03%]
一项事后分析：在疾病早期阶段接受抗抑郁药治疗但抑郁症症状未缓解的患者的辅助曲拉西林研究——两项随机对照试验的数据分析
Shivani Kapadia,Zhen Zhang,Csilla Csoboth et al.
Shivani Kapadia et al.
Background: Treatment for major depressive disorder (MDD) should be optimized as early as possible in the disease course to minimize patient suffering and maximize clinical benefits. This post hoc analysis aimed to invest...
Association between anhedonia severity and clinical, humanistic, and economic outcomes among US adults with major depressive disorder [0.03%]
美国成人重度抑郁症患者快感缺失严重程度与临床结局、人文关怀及经济负担之间的关系分析
Hrishikesh Kale,M Janelle Cambron-Mellott,Tiina Drissen et al.
Hrishikesh Kale et al.
Background: Anhedonia is a key symptom and part of the diagnostic criterion of major depressive disorder (MDD). However, the relationship between anhedonia severity and the clinical, humanistic, and economic burden among ...
David Benrimoh,Ryan Smith,Andreea O Diaconescu et al.
David Benrimoh et al.
Studying psychiatric illness has often been limited by difficulties in connecting symptoms and behavior to neurobiology. Computational psychiatry approaches promise to bridge this gap by providing formal accounts of the latent information p...
Yinuo Wang,Xiaobing Li,Min Liu et al.
Yinuo Wang et al.
More than 100 types of RNA modifications have been identified in mammalian cells, among which N6-methyladenosine (m6A) is the most prevalent. This reversible and dynamic modification involves methyltransferases, demethylases, and reader pro...
Predicting Antidepressant Responsiveness in MDD patients via EEG Gamma-Band Dynamic Functional Connectivity in Response to Salient Auditory Stimuli [0.03%]
基于脑电gamma频带动态功能连接预测抑郁症患者抗抑郁药物疗效
Kang-Min Choi,Taegyeong Lee,Seung-Hwan Lee et al.
Kang-Min Choi et al.
Background: Heterogeneous pathophysiological characteristics in patients with major depressive disorder (MDD) lead to individually differentiated sensitivities to antidepressants. Based on the hypothesis that gamma-band d...
Involvement of a stress-responsive orbito-striatal projection in impulsive action in male rats [0.03%]
与雄性大鼠冲动行为有关的应激反应轨道-纹状体投射的作用
Milena Girotti,Maisie G Boehmer-Cortez,Kathleen Tuite et al.
Milena Girotti et al.
Background: Motor impulsivity is a symptom shared by several psychiatric disorders. Stress exacerbates impulsivity, but the neurocircuits involved are unknown. We have shown that the orbitofrontal cortex (OFC) is activate...
Exploring the Influence of Synaptic Density and Anxiety on Pain Perception: Evidence from a [11C]UCB-J PET Imaging Study [0.03%]
基于[11C]UCB-J正电子发射断层扫描影像研究探索突触密度和焦虑对疼痛感知的影响
Karina Moisieienko,Ruth H Asch,Margaret T Davis et al.
Karina Moisieienko et al.
Background: Structural and functional brain alterations may be associated with pain and anxiety. We hypothesized that synaptic density (measured in vivo with [11C]UCB-J and positron emission tomography quantification of s...
Frequent Vocalizations and DBS-Responsive Hyperkinesia in a Striatal Disinhibition Rat Model for Tourette Syndrome [0.03%]
基于纹状体失抑制的Tourette综合征大鼠模型中的频繁发声和深部脑刺激响应性运动过多症
Boriss Sagalajev,Lina Lennartz,Niloofar Mokhtari et al.
Boriss Sagalajev et al.
Background: The lack of a rodent model for both motor and phonic tics hinders research on deep brain stimulation (DBS) for refractory Tourette syndrome (TS). Striatal disinhibition with a GABA-A antagonist (bicuculline) w...
NMDA Receptor Involvement in Dopaminergic Modulation of Neuroplasticity Induced by Paired Associative Stimulation [0.03%]
N-甲基-D天冬氨酸受体参与paired associative stimulation诱发的多巴胺能调节神经可塑性的作用
Marie C Beaupain,Elham Ghanavati,Amba M Frese et al.
Marie C Beaupain et al.
Background: Dopamine (DA) modulates long-term potentiation (LTP)-like neuroplasticity. While particularly D1 and D2 receptors are thought to influence neuroplasticity through glutamatergic NMDA receptor and GABA modulatio...
Pharmacological modulation of directed network communication and neural hubs in action-effect integration [0.03%]
药理学调制行动效果整合中的定向网络通讯和神经中枢
Jasmin Mayer,Anna Helin Koyun,Moritz Mückschel et al.
Jasmin Mayer et al.
Background: Acting intentionally requires individuals to anticipate the effects of their actions. Recent work has revealed the neural oscillatory dynamics underlying the establishment of action-effect bindings, which are ...