Divergent effects of interleukin-6 and ghrelin on remission and relapse in depression treatment [0.03%]
白细胞介素-6和胃泌素对抑郁症治疗的缓解期和复发期产生不同影响
Jae-Min Kim,Hee-Ju Kang,Ju-Wan Kim et al.
Jae-Min Kim et al.
Background: This study was to explore how serum ghrelin levels modulate the relationship between interleukin-6 (IL-6) and outcomes of antidepressant treatment, specifically focusing on 12-week remission and 24-month relap...
Secondary Restless Legs Syndrome during Psychopharmacological Treatment: Real-World Evidence from a Multinational Pharmacovigilance Program [0.03%]
药理学治疗期间继发的不安腿综合征：来自国际药物警戒项目的现实证据
Gernot Fugger,Ulrich Rabl,Lucie Bartova et al.
Gernot Fugger et al.
Secondary Restless Legs Syndrome (RLS) has repeatedly been associated with psychopharmacotherapy, especially antidepressants (ADs) and antipsychotics (APs). However, existing evidence is conflicting in terms of the magnitude of the associat...
Recent Cannabis Exposure and Acute Nicotine Effects: Insights from Randomized, Double-Blind, Placebo-Controlled Intravenous Nicotine Studies [0.03%]
近期大麻暴露与急性尼古丁效应：来自随机双盲安慰剂对照静脉注射尼古丁研究的启示
Gabriel P A Costa,R Ross MacLean,Mehmet Sofuoglu et al.
Gabriel P A Costa et al.
Objective: Cannabis-nicotine co-use is common and may affect cessation outcomes, yet whether recent cannabis exposure alters nicotine's acute effects in humans remains unclear. We examined whether recent, non-daily cannab...
Inhibition of FKBP51 alleviates depressive-like behaviors via AKT/mTOR-Dependent Autophagy and Synaptic Plasticity [0.03%]
FKBP51抑制通过AKT/mTOR依赖的自噬和突触可塑性缓解类似抑郁的行为
Chen Li,Junjie Huang,Hailong Ge et al.
Chen Li et al.
Background: Depression is a major global health problem, the pathogenesis of which remains to be elucidated, and current antidepressants exhibit limited efficacy. FK506-binding protein 51 (FKBP51) has been identified as a...
Trials, Trips, and Tribulations: Pathways for Implementing Psychedelic therapy in Ireland [0.03%]
试炼、旅行与挫折：在爱尔兰实施迷幻疗法的途径
John R Kelly,Christopher Sheridan,Patricia Iusan et al.
John R Kelly et al.
Classical serotonergic psychedelics, such as psilocybin, show emerging evidence of therapeutic potential across a range of mental health disorders, including depression, anxiety, and substance use disorders, with indications of transdiagnos...
Negative allosteric modulator of the metabotropic glutamate receptor 7 (mGlu7) ADX71743 increases wakefulness, reduces sleep and alters stress-induced changes in the brain neurotransmitter levels [0.03%]
代谢型谷氨酸受体7（mGlu7）负变构调节剂ADX71743增加觉醒，减少睡眠并改变压力引起的脑内神经递质水平变化
Mikhail Kalinichev,John A Gruner,Gunnar Flik et al.
Mikhail Kalinichev et al.
Objective: Converging evidence suggests that metabotropic glutamate receptor 7 (mGlu7) contributes to sleep-wake regulation and stress reactivity. We used the selective negative allosteric modulator (NAM) ADX71743 to exam...
Heterogeneity in adverse events associated with lumateperone: a study on potential subgroup-specific differences [0.03%]
卢马曲普兰不良事件的异质性：潜在亚组特异性差异的研究
Cheng Jiang,Luhan Tang,Mingqian Li et al.
Cheng Jiang et al.
Background: Lumateperone, a novel atypical antipsychotic, has emerged as an illuminating hope for patients with schizophrenia and bipolar disorder. While prior studies have employed spontaneous reporting databases and ide...
The introduction of measurement-based care for patients with schizophrenia may improve psychiatric symptoms and guideline adherence rate [0.03%]
基于测量的精神分裂症患者的护理可能改善精神病症状和指南遵循率
Keisuke Mori,Junya Matsumoto,Satsuki Ito et al.
Keisuke Mori et al.
Background: Measurement-Based Care (MBC) is a clinical approach that uses objective measurements to quantitatively assess patients' symptoms and conditions as the basis for treatment, with the assessments shared with pati...
Life Engagement Improvements with Cariprazine in Schizophrenia: A Post-Hoc Analysis of PANSS Data from Short-Term Studies [0.03%]
利培酮缓释混悬剂与口服利培酮片治疗精神分裂症有效性和耐受性的比较：一项随机双盲非劣效性研究
Réka Csehi,Péter Szabó,Zsófia Borbála Dombi et al.
Réka Csehi et al.
Objective: Patient life engagement (PLE) is increasingly recognised as a meaningful treatment goal in schizophrenia, yet it remains under-researched, partly due to the lack of validated PLE measures. This post-hoc analysi...
Late-onset major depression and subthreshold depressive symptoms as early clinical correlates of brain small vessel disease [0.03%]
脑小血管病的早期临床标志物：晚发重大抑郁症及临界抑郁症状
Calypso Α Mitkani,Thomas J Tegos,Vasilios K Kimiskidis et al.
Calypso Α Mitkani et al.
Background: Late-onset depression (LOD) and subthreshold depressive symptoms (SDS) have been associated with cerebral small vessel disease (SVD), but the evidence regarding pre-stroke depression remains limited. This stud...