Current and novel dual orexin receptor antagonists for the treatment of insomnia: the emergence of vornorexant [0.03%]
失眠症当前和新型双重食欲素受体拮抗剂：VOR 临床试验的新进展
Yukihiro Chino,Hiroyuki Sugiyama,Shigeyuki Chaki et al.
Yukihiro Chino et al.
Insomnia is a serious public health concern. As the widely prescribed hypnotics that positively modulate gamma-aminobutyric acid (GABA)A receptor activity have various safety concerns, there is a growing demand for the development of novel ...
Partial agonist antipsychotic drugs differentially interact with a secondary binding site at the dopamine D2 receptor [0.03%]
部分激动剂抗精神病药物通过与多巴胺D2受体的二级结合位点不同地相互作用而产生不同的药理作用
Richard Ågren,Kristoffer Sahlholm
Richard Ågren
Adjunctive brexpiprazole in patients with major depressive disorder who show minimal or partial response to antidepressant treatment: post hoc analysis of randomized controlled trials [0.03%]
在对现有抗抑郁治疗反应不佳的抑郁症患者中研究brexpiprazole附加疗法：随机对照试验的事后分析
Shivani Kapadia,Zhen Zhang,Ferhat Ardic et al.
Shivani Kapadia et al.
Importance: Many patients with major depressive disorder (MDD) have 0% to
Modulatory effects of GLT-1 enhancer, MC-100093, on glutamate uptake and associated signaling pathways in female and male alcohol preferring rats exposed to ethanol [0.03%]
GLT-1增强剂MC-100093调节酒精成瘾大鼠的谷氨酸摄取及相关信号通路的作用机制研究
Ahmed Alotaibi,Khokon Kanti Bhowmik,Woonyen Wong et al.
Ahmed Alotaibi et al.
Background: Ethanol consumption disrupts glutamate homeostasis in several brain regions. The uptake of extracellular glutamate is regulated in the majority by the astrocytic glutamate transporter 1 (GLT-1), and cystine-gl...
Methodological Considerations for Interpreting Ketamine-Naltrexone Trials in Depression [0.03%]
解读抑郁症酮氯普马试验的方法学考量
Igor D Bandeira,Luke A Jelen,Jason M Tucciarone et al.
Igor D Bandeira et al.
A longitudinal PET study on changes in brain norepinephrine transporter availability following duloxetine treatment in major depressive disorder [0.03%]
度洛西汀治疗对抑郁症患者脑去甲肾上腺素转运蛋白占有量的纵向影响——正电子发射计算机体层扫描研究
Sho Moriguchi,Keisuke Takahata,Harumasa Takano et al.
Sho Moriguchi et al.
Importance: The norepinephrine transporter (NET) plays a crucial role in major depressive disorder (MDD). Serotonin and norepinephrine reuptake inhibitors, such as duloxetine, are first-line treatments for MDD. Duloxetine...
Mechanism of the AMPK/SIRT1 pathway in gut dysbiosis-mediated postoperative cognitive dysfunction in aged mice [0.03%]
老年小鼠术后认知功能障碍的肠道菌群介导机制及AMPK/SIRT1通路的作用研究
Fu Xu,Yang Yue,Defeng Sun
Fu Xu
Objective: Postoperative cognitive dysfunction (POCD) is a prevalent complication in older patients who undergo surgery that requires anesthesia. This study explored the role of the AMPK/SIRT1 pathway in gut dysbiosis-med...
Neuropsychiatric- and cognitive post-acute sequelae of SARS-CoV-2 infection - evidence from K18-hACE C57BL/6 J mice [0.03%]
SARS-CoV-2感染小鼠的神经精神和认知后遗症-K18-hACE C57BL/6 J小鼠证据
Marco Maria Santi,Eleonora Genovese,Thor Mertz Schou et al.
Marco Maria Santi et al.
Background: Survivors of COVID-19 frequently report psychiatric and cognitive sequelae. The origin of such sequelae has not been determined, as it has been a challenge to resolve whether these symptoms have a viral origin...
Identification of peripheral biomarkers through metabolomic analysis in patients with bipolar disorder treated with mood stabilizers: an exploratory study [0.03%]
情绪稳定剂治疗的双相情感障碍患者中基于代谢组学分析的外周生物标志物识别探索性研究
Cristina Piras,Claudia Pisanu,Martina Spada et al.
Cristina Piras et al.
Importance: Bipolar disorder (BD) is mainly treated with mood stabilizers, among which lithium represents the gold standard. Despite its high clinical efficacy, the molecular players involved in lithium response and non-r...
Sex-differences in catecholamine transporter expression in the rodent prefrontal cortex following repetitive mild traumatic brain injury and methylphenidate treatment [0.03%]
重复性轻度创伤性脑损伤后啮齿动物前额皮质中多巴胺转运体的性别差异表达及其与哌甲酯治疗的关系研究
Eleni Papadopoulos,Anna Abrimian,Christopher P Knapp et al.
Eleni Papadopoulos et al.
Background: Irregular transmitter activity is theorized to underly impaired prefrontal cortex (PFC)-mediated executive functions following repetitive mild traumatic brain injury (rmTBI). The psychostimulant, methylphenida...