PDE4A knockdown rescues alcohol-induced cognitive impairment and synaptic dysfunction via the cAMP/PKA/CREB pathway [0.03%]
PDE4A敲低通过cAMP/PKA/CREB通路拯救酒精诱导的认知障碍和突触功能紊乱
Huan Tu,Rongzhen Sun,Shengyao Ma et al.
Huan Tu et al.
Background: Alcoholic dementia (AlD) is a severe neurological disorder with no effective treatment. Development of pan-phosphodiesterase-4 (PDE4) inhibitors for clinical treatment of neurological conditions has been hampe...
Ketamine effects on EEG and their links to therapy differ across treatment-resistant major depression, post-traumatic stress disorder, and obsessive-compulsive disorder [0.03%]
氯胺酮对难治性抑郁症、创伤后应激障碍和强迫症患者脑电图的影响及其与治疗反应的关系差异
Shabah M Shadli,Neda Nasrollahi,Calvin K Young et al.
Shabah M Shadli et al.
Background: Neurotic disorders - major depressive disorder (MDD), panic disorder, social anxiety disorder, generalized anxiety disorder, obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), and spec...
Genetic overlap between treatment-resistant schizophrenia and smoking initiation [0.03%]
难治性精神分裂症与吸烟发病的遗传重叠
Elise Koch,Nadine Parker,Helin H Mohammad et al.
Elise Koch et al.
Background: Early detection of treatment-resistant schizophrenia (TRS) is of substantial clinical importance. While TRS is heritable, the associated genetic variants have been difficult to identify. Cigarette smoking is a...
Pál Czobor,Brigitta Kakuszi,Máté Fullajtár et al.
Pál Czobor et al.
Viloxazine occupies the 5-HT2C receptor in the macaca fascicularis brain in vivo: A [11C]CIMBI-36 positron emission tomography study [0.03%]
体内佛洛沙明占据脑组织五味子素受体：一种猕猴脑[11C]CIMBI-36正电子发射断层扫描研究
Jennie Garcia-Olivares,Brittney Yegla,Khanum Ridler et al.
Jennie Garcia-Olivares et al.
Efficacy of viloxazine ER (extended-release capsules; Qelbree®) for attention-deficit/hyperactivity disorder (ADHD) is attributed to its ability to increase extracellular norepinephrine and dopamine in the medial prefrontal cortex by inhib...
Divergent effects of interleukin-6 and ghrelin on remission and relapse in depression treatment [0.03%]
白细胞介素-6和胃泌素对抑郁症治疗的缓解期和复发期产生不同影响
Jae-Min Kim,Hee-Ju Kang,Ju-Wan Kim et al.
Jae-Min Kim et al.
Background: This study was to explore how serum ghrelin levels modulate the relationship between interleukin-6 (IL-6) and outcomes of antidepressant treatment, specifically focusing on 12-week remission and 24-month relap...
Secondary Restless Legs Syndrome during Psychopharmacological Treatment: Real-World Evidence from a Multinational Pharmacovigilance Program [0.03%]
药理学治疗期间继发的不安腿综合征：来自国际药物警戒项目的现实证据
Gernot Fugger,Ulrich Rabl,Lucie Bartova et al.
Gernot Fugger et al.
Secondary Restless Legs Syndrome (RLS) has repeatedly been associated with psychopharmacotherapy, especially antidepressants (ADs) and antipsychotics (APs). However, existing evidence is conflicting in terms of the magnitude of the associat...
Recent Cannabis Exposure and Acute Nicotine Effects: Insights from Randomized, Double-Blind, Placebo-Controlled Intravenous Nicotine Studies [0.03%]
近期大麻暴露与急性尼古丁效应：来自随机双盲安慰剂对照静脉注射尼古丁研究的启示
Gabriel P A Costa,R Ross MacLean,Mehmet Sofuoglu et al.
Gabriel P A Costa et al.
Objective: Cannabis-nicotine co-use is common and may affect cessation outcomes, yet whether recent cannabis exposure alters nicotine's acute effects in humans remains unclear. We examined whether recent, non-daily cannab...
Inhibition of FKBP51 alleviates depressive-like behaviors via AKT/mTOR-Dependent Autophagy and Synaptic Plasticity [0.03%]
FKBP51抑制通过AKT/mTOR依赖的自噬和突触可塑性缓解类似抑郁的行为
Chen Li,Junjie Huang,Hailong Ge et al.
Chen Li et al.
Background: Depression is a major global health problem, the pathogenesis of which remains to be elucidated, and current antidepressants exhibit limited efficacy. FK506-binding protein 51 (FKBP51) has been identified as a...