Effects of Adjunctive Brexpiprazole with SSRI Treatment on Anxiety and Sleep Architecture in Mice [0.03%]
博拉匹扎隆联合选择性5-羟色胺再摄取抑制剂治疗对小鼠焦虑及睡眠结构的影响
Junya Maruoka,Kohei Kozuka,Ryo Egami et al.
Junya Maruoka et al.
Introduction: Major depressive disorder (MDD) is frequently accompanied by residual symptoms such as anxiety and sleep disturbances, even after adequate antidepressant treatment. Brexpiprazole, a serotonin-dopamine activi...
Conceptual and pragmatic clinical implications of dichotomizing psychotropics as targeting physiology - physiomodal and pathology - pathomodal [0.03%]
精神活性物质生理作用和病理作用的二元分类对临床实践的影响
Michael Berk,Stephen M Stahl,Lakshmi Yatham et al.
Michael Berk et al.
Conventional antidepressant, antipsychotics and mood stabilising drugs share several characteristics. Firstly, they have a slow onset of action with benefits accruing late that is broadly mediated by long term homeostatic processes. Respons...
Functional Inputs to the Subgenual Cingulate Cortex Differentiate Levels of Depressive Symptom Severity in Neurotypical Young Adults: Granger Causality and Clustering Analyses [0.03%]
功能输入区分典型神经发育青年成年人抑郁症严重程度：格兰杰因果关系和聚类分析
Huey-Ting Li,Yu Chen,Shefali Chaudhary et al.
Huey-Ting Li et al.
Extant research has implicated functional connectivity of the subgenual anterior cingulate cortex (sgACC) in major depressive disorders or depressive traits in neurotypical populations. However, prior studies have not distinguished the inpu...
Role of Glymphatic System Function in Cognitive Dysfunction Among Patients with Bipolar Disorder [0.03%]
胶质淋巴系统功能在双相情感障碍患者认知障碍中的作用
Mu-Hong Chen,Ying-Jay Liou,Ju-Wei Hsu et al.
Mu-Hong Chen et al.
Background: Increasing evidence has suggested a potential role of glymphatic system function in the pathomechanisms underlying mood disorders and related cognitive impairment. However, this association in bipolar disorder...
Identification of antidepressant response-related changes to DNA methylation and gene expression [0.03%]
用于识别抗抑郁剂反应相关的DNA甲基化和基因表达变化
Laura M Fiori,Corina Nagy,Gustavo Turecki
Laura M Fiori
Background: Major depressive disorder (MDD) is a debilitating condition that is commonly treated with antidepressants. However, many people do not respond to treatment, and the molecular mechanisms underlying antidepressa...
The Efficacy of Nutritional Phytochemical Compounds in Improving Cognition [0.03%]
植物化学营养成分改善认知功效的研究
Alexander Marsh,Darren Quelch,Marion Mackonochie et al.
Alexander Marsh et al.
The incidence of cognitive disorders is rising and medications to address cognitive impairments are limited. Phytochemical compounds have had some success in improving cognitive outcomes in preclinical studies. However, the evidence surroun...
Exploring the Association between Sweet Liking and Treatment Response to Naltrexone in Patients with Alcohol Use Disorder [0.03%]
探究甜食喜好与酒精使用障碍患者纳曲酮治疗反应之间的关系
Min-Chiao Chang,Chun-Hsin Chen,Shih-Chun Meng et al.
Min-Chiao Chang et al.
Background: Response to naltrexone varies among individuals with alcohol use disorder (AUD). Studies in Western populations have linked the sweet-liking (SL) phenotype, reflecting an individual's hedonic response to sweet...
Auricular Transcutaneous Vagus Nerve Stimulation Stabilizes Event Segmentation Through Modulation of Working Memory Representations [0.03%]
耳部经皮迷走神经刺激通过调节工作记忆表征稳定事件分段
Xianzhen Zhou,Foroogh Ghorbani,Veit Roessner et al.
Xianzhen Zhou et al.
Background: Segmenting continuous experience into discrete units-event segmentation-is fundamental for situational awareness and adaptive action. Based on Event Segmentation Theory (EST), we used auricular transcutaneous ...
Durability of the benefit of vagus nerve stimulation in markedly treatment-resistant major depression: a RECOVER trial report [0.03%]
迷走神经刺激治疗难治性抑郁症疗效的长期性——来自RECOVER试验的结果报告
Charles R Conway,Augustus John Rush,Scott T Aaronson et al.
Charles R Conway et al.
Importance: Greater levels of treatment resistance in major depressive disorder (MDD) are associated with lower rates of initial benefit and higher rates of relapse (lower durability). ...
Randomized Controlled Trial
The international journal of neuropsychopharmacology. 2026 Jan 6;29(1):pyaf080. DOI:10.1093/ijnp/pyaf080 2026
Pharmacokinetic and pharmacodynamic results from a randomized controlled study with the GHSR blocker PF-5190457 in recently abstinent patients with alcohol use disorder [0.03%]
PF-5190457（一种GHSR阻断剂）在最近停止饮酒的酒精使用障碍患者中的药代动力学和药效学结果：一项随机对照研究
Ryan E Tyler,Rabea K Pfaff,R M Naseer Khan et al.
Ryan E Tyler et al.
Objective: Ghrelin and LEAP2 act via the growth hormone secretagogue receptor (GHSR), which modulates feeding, alcohol use, and endocrine and immune system function. The GHSR blocker PF-5190457 has potential as a novel ph...