Genetic diversity of Koala retrovirus env gene subtypes: insights into northern and southern koala populations [0.03%]
考拉逆转录病毒env基因亚型的遗传多样性：对南北考拉种群的见解
Nishat Sarker,Jessica Fabijan,Jennifer Seddon et al.
Nishat Sarker et al.
Koala retrovirus (KoRV) is a recently endogenized retrovirus associated with neoplasia and immunosuppression in koala populations. The virus is known to display sequence variability and to be present at varying prevalence in different popul...
Daniel Wright,Jeroen Kortekaas,Thomas A Bowden et al.
Daniel Wright et al.
Rift Valley fever (RVF) is a mosquito-borne viral zoonosis that was first discovered in Kenya in 1930 and is now endemic throughout multiple African countries and the Arabian Peninsula. RVF virus primarily infects domestic livestock (sheep,...
Prevailing I292V PB2 mutation in avian influenza H9N2 virus increases viral polymerase function and attenuates IFN-β induction in human cells [0.03%]
禽流感H9N2病毒中的常见I292V PB2突变增强了病毒聚合酶活性并减弱了人源细胞中干扰素-β的诱导作用
Weihua Gao,Zhipeng Zu,Jiyu Liu et al.
Weihua Gao et al.
Adaptation of PB2 protein is important for the establishment of avian influenza viruses in mammalian hosts. Here, we identify I292V as the prevalent mutation in PB2 of circulating avian H9N2 and pandemic H1N1 viruses. The same dominant PB2 ...
A highly divergent hepacivirus-like flavivirus in domestic ducks [0.03%]
家鸭中的一种高变种的类hepacivirus 泰夫病毒
Lili Chu,Meiling Jin,Chonglun Feng et al.
Lili Chu et al.
Using random amplification and reverse transcription-PCR, a novel RNA virus was detected in sera of domestic ducks. The full genome of the virus was determined for three strains, identifying the first hepacivirus-like flavivirus in birds. T...
David Prangishvili,Tomohiro Mochizuki,Ying Liu et al.
David Prangishvili et al.
The family Clavaviridae includes viruses that replicate in hyperthermophilic archaea from the genus Aeropyrum. The non-enveloped rigid virions are rod-shaped, with dimensions of about 143×16 nm, and have terminal cap structures, one of whi...
Tula orthohantavirus nucleocapsid protein is cleaved in infected cells and may sequester activated caspase-3 during persistent infection to suppress apoptosis [0.03%]
图拉亨塔avirus核蛋白在感染细胞中被切割并在持续性感染中可结合活化型半胱氨酸蛋白酶-3来抑制细胞凋亡
Katherine Davies,Babak Afrough,Jamel Mankouri et al.
Katherine Davies et al.
The family Hantaviridae mostly comprises rodent-borne segmented negative-sense RNA viruses, many of which are capable of causing devastating disease in humans. In contrast, hantavirus infection of rodent hosts results in a persistent and in...
Codon optimization of G protein enhances rabies virus-induced humoral immunity [0.03%]
优化G蛋白密码子可增强狂犬病毒诱导的体液免疫反应
Jie Pei,Fei Huang,Qiong Wu et al.
Jie Pei et al.
Rabies, caused by rabies virus (RABV), is a fatal zoonosis, which still poses a threat to public health in most parts of the world. Glycoprotein of RABV is the only viral surface protein, which is critical for the induction of virus-neutral...
Trying to treat the untreatable: experimental approaches to clear rabies virus infection from the CNS [0.03%]
尝试治疗不治之症：清除中枢神经系统中狂犬病毒实验方法
Samuel P Smith,Guanghui Wu,Anthony R Fooks et al.
Samuel P Smith et al.
Rabies virus causes an invariably fatal encephalitis following the onset of clinical disease. Despite the availability of safe and effective vaccines, the clinical stages of rabies encephalitis remain untreatable, with few survivors being d...
Prevalence of a vertically transmitted single-stranded DNA virus in spinybacked orbweavers (Gasteracantha cancriformis) from Florida, USA [0.03%]
美国佛罗里达州球腹园蛛(Gasteracantha cancriformis)垂直传播的单链DNA病毒的流行病学研究
Karyna Rosario,Kaitlin A Mettel,Anthony M Greco et al.
Karyna Rosario et al.
Spiders (order Araneae, class Arachnida) are an important group of predatory arthropods in terrestrial ecosystems that have been recently identified as an untapped reservoir of single-stranded (ss)DNA viruses. Specifically, spiders harbour ...
A peptide-based inhibitor of gp96 suppresses HBsAg expression and HBV replication by upregulation of p53 [0.03%]
基于肽的gp96抑制剂通过上调p53来抑制HBsAg表达和HBV复制
Liyuan Qian,Hongxia Fan,Ying Ju et al.
Liyuan Qian et al.
In hepatitis B virus (HBV) infection, the virus produces redundant hepatitis B surface antigen (HBsAg) that plays a key role in driving T-cell tolerance and viral persistence. However, currently available anti-HBV agents have no direct effe...