Decoding the antiviral potential of eugenol, thymol and vanillin against human cytomegalovirus infection [0.03%]
Clara Martín-Martín,María Ruiz-Rico,José Manuel Barat et al.
Clara Martín-Martín et al.
Human cytomegalovirus (HCMV) poses serious health risks, particularly for immunocompromised individuals. However, the current FDA-approved anti-HCMV drugs face challenges such as drug resistance and significant side effects, underscoring th...
Kenta Teruya,Shirou Mohri,Tetsuyuki Kitamoto
Kenta Teruya
Differentiating Creutzfeldt-Jakob disease (CJD) with the V180I mutation from other types of dementia is extremely difficult. Additionally, its differentiation is sometimes determined after performing neurosurgery, which is associated with a...
Apoorva Prabhu,Christian Rinke
Apoorva Prabhu
The family Apasviridae includes dsDNA viruses associated with the marine archaeal lineage Poseidoniales. Members of this family have been identified using metagenomic analyses of brackish estuarine samples and are related to other 'magrovir...
David Hatfield,William Rodriguez,Timothy Mehrmann et al.
David Hatfield et al.
Processing bodies (P-bodies/PBs) are non-membranous foci involved in coordinating RNA fate by regulating translation and mRNA decay. In this study, we characterize the anti-viral factor Shiftless (SHFL) as a potent disruptor of PB dynamics....
Multiple origins and functions: evolutionary pathways of HSP70 proteins in viruses [0.03%]
多起源和功能：病毒HSP70蛋白的进化途径
Ayoub Maachi,Santiago F Elena
Ayoub Maachi
Heat shock protein 70s (HSP70s) are highly conserved molecular chaperones found across all domains of life, where they play essential roles in cellular stress responses. Whilst HSP70 homologues have been previously identified in closterovir...
Evaluating how infectious bursal disease virus (IBDV) infection influences influenza H3N8 challenge in chickens [0.03%]
评估传染性法氏囊病病毒(IBDV)感染对鸡只流感H3N8强毒的影响力
Salik Nazki,Chandana Tennakoon,Vishwanatha R A P Reddy et al.
Salik Nazki et al.
Infectious bursal disease virus (IBDV) causes an endemic immunosuppressive disease in chickens. Prior exposure to IBDV influences the pathogenesis and shedding of chicken strains of influenza A virus (IAV), but its effect on waterfowl strai...
Knockout of key receptors (PDGFRA and NRP2) in the guinea pig model blocks direct and endocytic pathways of CMV cell entry [0.03%]
在巴氏 Guinea Pig 模型中敲除关键受体(PDGFRα 和 NRP2) 阻止了 CMV 进入细胞的直接和内吞途径
Yushu Qin,K Yeon Choi,Nadia El-Hamdi et al.
Yushu Qin et al.
The guinea pig with guinea pig cytomegalovirus (GPCMV) is the only small-animal model for congenital cytomegalovirus, a leading cause of cognitive impairment and hearing loss in newborns. GPCMV encodes human cytomegalovirus (HCMV) homologue...
Immunogenicity of SARS-CoV-2 vaccine prototype based on virus-like particles of hepatitis B core antigen from genotype G and interleukin 12 expressing Semliki Forest virus as a genetic adjuvant [0.03%]
基于G基因型乙型肝炎核心抗原病毒样颗粒和表达白细胞介素12的塞姆利基森林病毒遗传佐剂的SARS-CoV-2疫苗原型免疫原性研究
Andris Dislers,Olga Nilova,Juris Jansons et al.
Andris Dislers et al.
Virus-like particles (VLPs) based on hepatitis B core antigen (HBc) represent an immunogenic and modular platform for epitope presentation. In this study, the VLPs formed by the modified recombinant hepatitis B core antigen from genotype G ...
A solinvivirus induces cellular antiviral responses and reduces the lifespan of adult black soldier flies [0.03%]
一种Solinvirus诱导细胞抗病毒反应并减少黑Soldierfly的寿命
Robert D Pienaar,Pablo García-Castillo,Harmony Piterois et al.
Robert D Pienaar et al.
Viral pathogens pose an emerging threat to the sustainability of insect mass-rearing systems, yet they remain understudied in key species like the black soldier fly (BSF; Hermetia illucens). Although multiple viral sequences have been repor...
In vivo inhibition of JAK-STAT signalling enhances high pathogenicity influenza virus replication in ducks [0.03%]
体内抑制JAK-STAT信号通路增强流感病毒在鸭体内的复制力
Juliette Gross,Bertille Pouget,Margot Sarrat et al.
Juliette Gross et al.
While rapid death is the usual outcome of high pathogenicity avian influenza virus (HPAIV) infection in gallinaceous poultry, HPAIV-infected ducks usually present milder clinical signs and shed virus for a prolonged time. The difference in ...