Synthesis and preclinical evaluation of 89Zr-DFO-atezolizumab for immuno-PET imaging in colorectal cancer [0.03%]
用于结直肠癌免疫分子影像的89Zr-DFO-atezolizumab的合成及临床前评价研究
Siqi Hao,Yang Jiang,Qian Chen et al.
Siqi Hao et al.
The immune checkpoint programmed ligand 1 (PD-L1) is expressed in various solid tumors and is associated with immunotherapy prognosis. Dynamic assessment of PDL1 expression levels helps identify patients who may benefit from immunotherapy. ...
Design, synthesis and antiproliferative properties of 7-azaindole linked imidazole - 1,2,3-triazole hybrids and computational screening [0.03%]
基于7-氮杂吲哚与咪唑-1,2,3-三氮唑的杂环联苯类化合物的设计、合成及其抗增殖活性和计算机辅助药物筛选研究
Murali Krishna Vanga,Vishnu Thumma,Rambabu Bhukya et al.
Murali Krishna Vanga et al.
A series of 7-Azaindole Linked Imidazole 1,2,3-Triazole hybrids were synthesized and assessed for their anticancer activity across five distinct cancer cell lines: DU-145 (prostate cancer), MCF-7 (breast cancer), HCT 116 (colon cancer), HeL...
Discovery of GSI526: a potent IRAK4-targeting PROTAC degrader with efficient degradation and suppression of inflammatory signaling [0.03%]
高效炎症信号抑制和降解的IRAK4靶向PROTAC降解剂GSI526的发现
Bingjie Yin,Zhishuo Gao,Yan Ma et al.
Bingjie Yin et al.
Interleukin-1 receptor-associated kinase 4 (IRAK4) is a promising therapeutic target for inflammatory diseases. However, inhibition of its kinase activity alone often results in incomplete blockade of inflammatory signaling and limited ther...
Development of isoxazole tethered 1,2,3-triazoles and sulphonamide derivatives as potent anti-bacterial and anti-cancer agents [0.03%]
具有异唑连接的1,2,3-三氮唑和磺胺衍生物作为有效的抗菌和抗肿瘤剂的发展研究
Priyanuj Krishnann Hazarika,Sanjeeb Kalita,Debajit Mahanta et al.
Priyanuj Krishnann Hazarika et al.
This study addresses the design and development of novel isoxazole molecules tethered with triazole and sulphonamide derivatives to elucidate their pharmacological response for antibacterial and anticancer activities. The ionic liquid media...
Design, synthesis, and biological evaluation of novel probe-quality EGFR degraders targeting wild-type and Del19 mutation [0.03%]
新型探针质量EGFR降解剂的设计、合成及生物学评价：针对野生型和Del19突变型研究
Xiaomeng Gong,Mingyue Zhang,Jingli Min et al.
Xiaomeng Gong et al.
Epidermal growth factor receptor (EGFR) serves as a key therapeutic target for solid tumors such as non-small cell lung cancer (NSCLC), where its mutations and overexpression often lead to sustained activation of oncogenic signaling pathway...
Inhibitory effects of thiophene-2-thiazole hybrids against sensitive strains and resistant clinical isolates of Mycobacterium tuberculosis [0.03%]
噻吩-2-噻唑杂化物对结核分枝杆菌敏感菌株和临床耐药分离株的抑制作用
Paulo Fernando da Silva Santos-Júnior,Valnês da Silva Rodrigues-Junior,Manuele Figueiredo da Silva et al.
Paulo Fernando da Silva Santos-Júnior et al.
Tuberculosis (TB) remains a major global health challenge, particularly due to the rise of drug-resistant Mycobacterium tuberculosis (Mtb). Herein, a focused small library of thiophene-thiazole hybrid derivatives 3a-d bearing an imide linke...
Design and synthesis of [1,2,4]triazolo[3,4-b]thiadiazine-1,2,4-oxadiazoles as EGFR tyrosine kinase inhibitors [0.03%]
设计和合成作为EGFR酪氨酸激酶抑制剂的[1,2,4]三氮唑并[3,4-b]-硫代二嗪-1,2,4-恶二唑类化合物
Jallala Raju,Ramesh Kola,Srinivas Kumar et al.
Jallala Raju et al.
A novel series of heterocyclic compounds was developed, synthesized, and assessed for their in vitro anticancer efficacy and EGFR inhibitory activities. The cytotoxicity of the synthesized compounds was evaluated against A-549 and NCI-H460 ...
Design, synthesis, and biological evaluation of sphingosine kinase 2 inhibitors derived from K145 [0.03%]
来源于K145的鞘氨醇激酶2抑制剂的设计、合成及生物活性评价
Junru Liu,Xiujuan Shi,Xinmei Yang et al.
Junru Liu et al.
Sphingosine-1-phosphate (S1P) is a critical bioactive lipid mediator that regulates essential cellular processes-including proliferation, survival, migration, and inflammation-through binding to its cognate receptors (S1PRs) on the cell mem...
Discovery of novel hydroxime-based NLRP3 inflammasome inhibitors with reduced hepatotoxicity [0.03%]
发现一类新型的NLRP3炎性小体抑制剂：具有降低肝毒性的羟胺类化合物
Wei Li,Yaxuan Gao,Anhua Huang et al.
Wei Li et al.
The NOD-like receptor thermal protein domain associated protein 3 (NLRP3) inflammasome plays a critical role in mediating intracellular caspase-1 activation, IL-1β release, and pyroptosis with its excessive activation being closely associa...
Corrigendum to "Optimization of clofibrate by carvacrol results in a new hypolipidemic compound with low hepatic injury" [Bioorg. Med. Chem. Lett. 120 (2025) 130116] [0.03%]
关于“百里酚优化克罗菲布为新的低肝损伤降血脂化合物”一文的勘误[_bioorg. med. chem. lett. 120 (2025) 130116]
Xinyi Shi,Yumiao Song,Xinyu Zhang et al.
Xinyi Shi et al.
Published Erratum
Bioorganic & medicinal chemistry letters. 2026 Apr 22:130658. DOI:10.1016/j.bmcl.2026.130658 2026