Caffeic acid phenethyl ester derivatives inhibit glyoxalase I activity and induce cell death in cultured cancer cell lines [0.03%]
咖啡酸苯乙酯衍生物通过抑制糖醛酶I活性诱导培养的癌细胞系凋亡
Shuji Ishizaki,Aya Nishida,Kanako Nakamine et al.
Shuji Ishizaki et al.
Glyoxalase I (GLO I) is the rate-limiting enzyme responsible for the detoxification of methylglyoxal, a toxic byproduct of anaerobic glycolysis. GLO I is highly expressed in various tumors and has therefore been recognized as a promising ta...
Synthesis, computational and in vitro anti-tubercular activity studies of thiadiazole-linked pyridazinone derivatives [0.03%]
噻二唑联吡啶酮衍生物的合成、计算及体外抗结核活性研究
Neeru Bhanwala,Niranjana Sri Sundaramoorthy,Nimbark Yash Dhirajlal et al.
Neeru Bhanwala et al.
Mycobacterium tuberculosis (Mtb) is an infectious bacterium that causes pulmonary tuberculosis (TB). The emergence of drug-resistant Mtb strains necessitates the need for the identification of novel antitubercular agents. In this study, we ...
Erratum to "Development of a novel PI3Kα/CDK7 potent hybrid inhibitor for Cancer treatment" [Bioorg. Med. Chem. Lett. 140 (2026) 130738] [0.03%]
关于“用于癌症治疗的新型PI3Kα/CDK7强效杂合抑制剂的开发”一文的勘误[Bioorg. Med. Chem. Lett. 140 (2026) 130738]
Ghassan M Abushaikha,Tyler J Chitwood,Abdel Bayazid et al.
Ghassan M Abushaikha et al.
Published Erratum
Bioorganic & medicinal chemistry letters. 2026 Aug 10:130748. DOI:10.1016/j.bmcl.2026.130748 2026
Discovery of orally available benzimidazole-based STING antagonists with in vivo activity [0.03%]
新型口服STING拮抗剂苯并咪唑衍生物的发现及体内活性研究
Takao Kiyoi,Hirokazu Matsumoto,Shiori Takamatsu et al.
Takao Kiyoi et al.
Stimulator of interferon genes (STING) plays a pivotal role in the innate immune system. However, aberrant activation of the STING pathway has been implicated in the development of autoimmune and inflammatory diseases. Herein, we report the...
Retraction notice to "Rational design and translational advancement of phospholipid-based nanocarriers for targeted cancer therapy" [Bioorg. Med. Chem. Lett. 129 (2025) 130396] [0.03%]
关于“基于磷脂的纳米载体的合理设计和转化应用以实现靶向癌症治疗”的撤稿声明[Bioorg. Med. Chem. Lett. 129 (2025) 130396]
Kateryna Mykhailivna Doroshenko,Oleksander Ivanovich Shefchenko
Kateryna Mykhailivna Doroshenko
Published Erratum
Bioorganic & medicinal chemistry letters. 2026 Aug 5:130746. DOI:10.1016/j.bmcl.2026.130746 2026
Novel salicylamido sulfonamides as CD73 immune checkpoint inhibitors: Synthesis and in vitro biological evaluation [0.03%]
新型水杨酰胺磺胺类CD73免疫检查点抑制剂：合成与体外生物活性评估
Dinesh Krishna Narukulla,Shrilekha Chilvery,Chandraiah Godugu et al.
Dinesh Krishna Narukulla et al.
The immune checkpoint enzyme CD73 plays a crucial role in the adenosine (ADO) metabolic pathway by catalyzing the conversion of AMP to adenosine. Dysregulated CD73 activity elevates extracellular ADO in the tumor microenvironment, driving i...
Design and synthesis of dual-target CDK9-EZH2 inhibitors using a pharmacophore fusion strategy [0.03%]
基于药效团融合策略的靶向CDK9和EZH2双靶点抑制剂的设计与合成
Yixue Han,Ruiqi Wang,Lina Tian et al.
Yixue Han et al.
Cyclin-dependent kinase 9 (CDK9), a key member of the CDK family, plays a crucial role in transcriptional regulation. As its expression is dysregulated in various cancers, CDK9 is regarded as a promising therapeutic target. However, the cli...
Toward targeted covalent inhibition of Cruzipain for the treatment of Chagas disease [0.03%]
克鲁兹帕扬共价抑制的靶向治疗策略用于查加斯病治療
Juan Ignacio Estrada Canepa,Sergio Román Ribone,Agustina Grich et al.
Juan Ignacio Estrada Canepa et al.
Chagas disease (CD), caused by the protozoan parasite Trypanosoma cruzi (T. cruzi), remains a neglected tropical disease with limited therapeutic options. Cruzipain (CZP), the main cysteine protease of T. cruzi, has been extensively validat...
Development of karapinchamine A-related carbazoles with antiproliferative activity against glioblastoma-derived cancer stem cells and blood-brain barrier permeability [0.03%]
具有抗胶质母细胞瘤来源的癌症干细胞增殖活性和可通过血脑屏障的卡拉平查明A类似咔唑生物碱的发展
Haruka Kawatake,Sakura Ichioka,Yutaro Ohki et al.
Haruka Kawatake et al.
Karapinchamine A (1)-a geranylated carbazole isolated from the leaves of Bergera koenigii (syn. of Murraya koenigii) (curry leaf)-was synthesized together with twelve N-substituted carbazole derivatives. Their antiproliferative activities w...
Synthesis and preliminary biological evaluation of resveratrol-like carbostyril derivatives as sirtuin 1 modulators and cyclooxygenase inhibitors [0.03%]
茋类白藜芦醇类似物的合成及SIRT1调节剂和环氧合酶抑制剂的初步生物活性研究
Toshihiko Tashima,Yoshinori Suzuma,Hiroaki Murata et al.
Toshihiko Tashima et al.
Resveratrol is an antioxidant polyphenolic compound found in grape skins and red wine. It has been suggested that resveratrol mediates sirtuin 1 (SIRT1) activation, leading to anti-aging, life extension, and anti-cancer effects as demonstra...