Non-chromatographic purification of guide RNA for gene-editing experiments [0.03%]
用于基因编辑实验的导向RNA的非色谱纯化方法
Ian M McClain,Nihal S Yigit,Maksim Royzen
Ian M McClain
CRISPR-Cas12a gene editing technology is gaining momentum as a powerful tool for many biochemical and medicinal applications. The technology requires guide RNA, which is typically made using solid phase synthesis and purified by HPLC. The l...
Unlocking the potential of ommatins as sustainable photosensitizers for photodynamic therapy [0.03%]
解锁ommatin作为光动力疗法可持续光敏剂的潜力
Arif Hussain,Anthony A Ruberto,Harsh Bhatia et al.
Arif Hussain et al.
Photodynamic therapy (PDT) has demonstrated efficacy in cancer treatment, with recent advancements concentrating on photosensitizers that generate high levels of reactive oxygen species (ROS) upon light irradiation while exhibiting minimal ...
Development of a novel PI3Kα/CDK7 potent hybrid inhibitor for Cancer treatment [0.03%]
用于癌症治疗的新型PI3Kα/CDK7强效杂合抑制剂的开发
Ghassan M Abushaikha,Tyler J Chitwood,Abdel Bayazid et al.
Ghassan M Abushaikha et al.
Phosphatidylinositol 3-kinase alpha (PI3Kα) and cyclin-dependent kinase 7 (CDK7) play key roles in the growth of multiple cancers. PI3Kα indirectly activates and enhances CDK7 expression. Our preliminary findings from screening recombinan...
Targeting the Heme biosynthesis pathway: strategies to enhance 5-ALA-mediated photodynamic therapy [0.03%]
针对血红素生物合成途径的研究：增强5-氨基乙酰丙酸介导的光动力疗法策略
Jinhui Ren,Yinghui Li,Jiani Fu et al.
Jinhui Ren et al.
Photodynamic therapy (PDT) is an efficient clinical treatment option for cancerous tumors. At present, 5-aminolevulinic acid (5-ALA) is the drug most frequently utilized in PDT. 5-ALA serves as a precursor for porphyrin, heme, and bile pigm...
N-Heterocyclic sulfonamides and sultams as inhibitors of the bacterial enzyme diaminopimelate desuccinylase (DapE) [0.03%]
作为细菌酶焦谷氨酸去乙酰酶(DapE)抑制剂的含氮杂环磺胺和亚磺胺类化合物
Sebastian Flieger,Emma Kelley,Megan Beulke et al.
Sebastian Flieger et al.
Diaminopimelate desuccinylase (DapE) is a promising antibacterial target involved in lysine biosynthesis and bacterial cell wall formation. Previously, N-aryl sulfonamide hit 1 (IC₅₀ = 72.9 μM) was optimized to 2 with enhanced potency (I...
Design, synthesis and SAR exploration of 3-substituted 1,2,3,4-tetrahydroisoquinoline (THIQ) as sigma ligands [0.03%]
作为σ受体配体的3位取代的1,2,3,4-四氢异喹啉(THIQ)的设计、合成及构效关系研究
Dikshita Lama,A Michael Crider,Marcelo Nieto
Dikshita Lama
Sigma receptors (σ₁R and σ₂R) are emerging therapeutic targets implicated in neurodegenerative, oncological, and psychiatric disorders. This study explores the design, synthesis, and SAR of 3-substituted tetrahydroisoquinoline (THIQ) li...
Hexadentate 3-hydroxypyridin-4(1H)-ones as dual biofilm inhibition and dispersion agents against Pseudomonas aeruginosa potentiate ciprofloxacin activity [0.03%]
3-羟基吡啶-4(1H)-二齿螯合剂作为防治铜绿假单胞菌生物膜的双效抑制和分散剂，可增强环丙沙星活性
Yuan-Yuan Wang,Tong-Tong Chen,Chang-Ming Li et al.
Yuan-Yuan Wang et al.
Opportunistic Gram-negative Pseudomonas aeruginosa (P. aeruginosa) often causes complicated infections with the formation of biofilm, which contribute to its resistance to antibiotics. Quorum sensing (QS) inhibitors has been developed as an...
6-(5-bromo-2-hydroxybenzoyl)-2-((3-methoxyphenyl)amino)pyrazolo[1,5-a]pyrimidine-3‑carbonitrile promotes apoptosis by blocking the ERK MAP K-MCL1 signaling pathway in H1975 non-small cell lung cancer cells [0.03%]
6-(5-溴-2-羟基苯甲酰基)-2-((3-甲氧基苯基)氨基)吡唑并[1,5-a]嘧啶-3-腈通过阻断ERK-MCL1信号通路促进H1975非小细胞肺癌细胞凋亡
HeeWon Kang,Seunghyun Ahn,Euitaek Jung et al.
HeeWon Kang et al.
Aberrant activation of the ERK mitogen-activated protein kinase (MAPK) pathway contributes to the progression and therapeutic resistance of non-small cell lung cancer (NSCLC) by promoting the expression of pro-survival proteins, including m...
99ᵐTc-DTPA-OM: Cardiac-myosin targeted SPECT agent for non-invasive myocardial infarction imaging [0.03%]
99mTc-DTPA-OM：一种用于非侵入性心肌梗死成像的靶向心脏肌球蛋白SPECT试剂
Venkateshwararao Eeda,Neeraj S Thakur,Bojjibabu Chidipi et al.
Venkateshwararao Eeda et al.
Effective molecular imaging of myocardial infarction (MI) requires small, selective agents that can access damaged tissue and bind to intracellular biomarkers exposed during necrosis. Here, we report the development of 99mTc-DTPA-OM, a nove...
Design, synthesis and structure-activity relationship analysis of bufalin as antitumor agents [0.03%]
作为抗肿瘤剂的蟾毒灵的设计、合成及构效关系分析
Yao-Chen Wu,Min-Hui Chen,Meng-Yuan Zhang et al.
Yao-Chen Wu et al.
Two series of bufalin derivatives including three compounds were designed, synthesized, and evaluated for their antiproliferative activity against A549 (non-small cell lung cancer) and HeLa (cervical cancer) cells. Structure-activity relati...