Design, synthesis and antibacterial activity of novel LpxC inhibitors containing 1,2,3-triazole moieties
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Two series of N-aryl-L-threonine derivatives bearing a triazole fragment are described as LpxC inhibitors targeting Gram-negative pathogens. Most compounds demonstrated stronger antibacterial activities against E. coli (MICs: ≤0.03-16 μg/mL). Compounds a5, b... ...
