Metformin Alleviates High Glucose-Induced Pyroptosis and Inflammatory Responses in HK-2 Cells via SIRT1-Associated Regulation of the TXNIP/NLRP3 Pathway [0.03%]
二甲双胍通过SIRT1介导的TXNIP/NLRP3信号通路调节缓解高糖诱导的HK-2细胞焦亡及炎症反应
Shuyu Shi,Bing Wang,Yang Zhou et al.
Shuyu Shi et al.
Background: Diabetic kidney disease (DKD) is a major cause of renal failure and end-stage renal disease. Pyroptosis, a Gasdermin-dependent inflammatory form of programmed cell death, has been implicated in DKD progression...
Artificial Intelligence Analysis of Standard 12-Lead Electrocardiograms for Screening of Symptomatic Diabetic Peripheral Neuropathy [0.03%]
用于筛查症状性糖尿病外周神经病变的12导联标准心电图人工智能分析
Paweł Ignacy,Hanadi Aldosari,Krzysztof Irlik et al.
Paweł Ignacy et al.
Aim: To investigate whether artificial intelligence (AI) models trained on standard 12-lead electrocardiograms (ECG) can identify symptom-defined diabetic peripheral neuropathy (DPN) as assessed by the Michigan Neuropathy...
Observational Study
Diabetes, obesity & metabolism. 2026 Nov;28(11):10330-10342. DOI:10.1111/dom.71240 2026
Efficacy and Safety of SGLT2 Inhibitors in Patients With Genetic Lipodystrophy: A Real-Life Experience From a National Reference Network [0.03%]
遗传性脂代谢紊乱患者中钠-葡萄糖协同转运蛋白2抑制剂的疗效和安全性：国家医学中心联盟的真实世界经验分析
Léna Robert,Ines Belalem,Corinne Vigouroux et al.
Léna Robert et al.
Aim: Lipodystrophy syndromes are rare diseases with metabolic and cardiovascular consequences. This study explores the metabolic and renal effects of sodium-glucose cotransporter 2 inhibitors (SGLT2i) in patients with gen...
Hypercortisolism: An Under-Recognised Pathway Linked to Multi-System Complications [0.03%]
库欣反应再思考：一个被忽视的多系统并发症发病机制路径
Hernan Daniel Sacoto,Vivian A Fonseca
Hernan Daniel Sacoto
The clinical understanding of hypercortisolism (HC) has evolved from a classic overt syndrome with florid Cushingoid features to a broader spectrum of disease that includes milder presentations, often referred to as mild autonomous cortisol...
Linking Metabolic Subgroups and Adverse Pregnancy Outcomes in GDM: A Complementary Analytic Approach of Logistic Regressions and Machine Learning [0.03%]
基于逻辑回归和机器学习的妊娠糖尿病代谢亚组与不良结局关联研究
Yanjing Zeng,Jing Zhou,Zhengbin Ou et al.
Yanjing Zeng et al.
Aims: Associations between metabolic heterogeneity in women with gestational diabetes mellitus (GDM) and adverse pregnancy outcomes have often been explored without considering interrelated metabolic biomarkers, limiting ...
A Comprehensive Body Shape Evaluation System With Population Reference Ranges for Improved Disease Identification: Evidence From the China National Health Survey [0.03%]
基于人群参考范围的全面体型评估系统可改善疾病识别能力：来自中国健康调查的证据
Huijing He,Zhiyue Zhang,Qiaolu Cheng et al.
Huijing He et al.
Aims: To establish age- and sex-specific reference percentiles for body shape indices in Chinese adults and to develop a composite body shape index (CBSI) for age-related chronic diseases screening. ...
Oral Butyrate Reduces Progression of Kidney Damage in an L-NAME-Induced Diabetic Kidney Disease Mouse Model [0.03%]
口服丁酸盐可减轻L-NAME诱导的糖尿病肾病小鼠模型的肾脏损伤进展
Maria Novella Nicese,Angela Koudijs,Reshma Lalai et al.
Maria Novella Nicese et al.
Aims: Diabetic kidney disease (DKD) is one of the main causes of kidney failure worldwide. Interestingly, patients affected by DKD are characterised by a low abundance of gut bacteria producing short fatty acids including...
Baseline HDL Cholesterol and the Anti-VEGF Injection-Sparing Effect of an SGLT2 Inhibitor in Diabetic Macular Oedema: A Post Hoc Analysis of the COMET Trial [0.03%]
基线HDL胆固醇水平与SGLT2抑制剂在糖尿病黄斑水肿中的抗VEGF注射减量效应：COMET试验的事后分析
Ryoichi Ishibashi,Masaya Koshizaka,Kiichi Hirayama et al.
Ryoichi Ishibashi et al.