Antibacterial drug discovery: challenges and preclinical promises from synthetic small molecules [0.03%]
抗菌药物发现：合成小分子面临的挑战与临床前应用展望
Guilherme F S Fernandes,Seong-Heun Kim,Jean L Dos Santos et al.
Guilherme F S Fernandes et al.
Over the past few decades, antibacterial discovery has changed substantially, yet innovation has remained slow despite the growing need for new agents active against multidrug-resistant pathogens. Progress is constrained by scientific hurdl...
Qixue Qin,Xiao-De An,Shuanghong Hao et al.
Qixue Qin et al.
The selective cleavage of carbon-carbon (C-C) bonds has emerged as a powerful tool for molecular deconstruction and skeletal editing. However, the inherent strength and low polarity of C-C bonds render their selective scission a formidable ...
Circularly polarized luminescence: an easy path from molecules to supramolecular systems and beyond [0.03%]
从分子到超分子体系乃至更广泛的圆偏振发光：易如反掌
Francesco Bertocchi,Davide Giavazzi,Shahana Nizar et al.
Francesco Bertocchi et al.
This tutorial offers an easy access point to the hot topic of circularly polarized luminescence (CPL), focusing on organic materials. Some basic concepts about chiroptical responses are presented and the subtleties associated with reliable ...
Biological conversion of CO2 for bioproduction: beyond natural limitations [0.03%]
突破自然限制，实现二氧化碳向生物产品的转化
Chunlei Zhao,Pan Zhu,Tiantian Chai et al.
Chunlei Zhao et al.
Natural biological CO2 fixation converts atmospheric CO2 to energy-dense carbohydrates, thereby providing an alternative to fossil fuels and contributing to the restoration of carbon balance. Recent advancements in the mechanisms of biologi...
Arup Jyoti Das,Shivhar B Ambegave,Aliya V Jinilkumar et al.
Arup Jyoti Das et al.
Multimetallic catalysis has emerged as a powerful strategy in modern organic synthesis, offering access to reaction pathways and selectivity patterns that are unattainable with a single-metal catalyst. Within this landscape, gold-based mult...
Advanced fluorine chemistry in >4.2 V high-voltage lithium metal batteries [0.03%]
高电压锂金属电池中氟化物的高级化学反应
Yu Sun,Junjie Du,Daxian Zuo et al.
Yu Sun et al.
Lithium metal batteries (LMBs), operating at high voltage (>4.2 V), exhibit unprecedented energy density (>400 Wh kg-1), but are restricted by uncontrollable Li dendrites, enigmatic interfacial chemistries, and unstable solid electrolyte in...
Usman Ghani,Farman Ullah,Junying Zhang et al.
Usman Ghani et al.
Proton battery (PB) technology has regained attention in recent years as a promising energy storage alternative to conventional lithium-ion batteries due to its excellent electrochemical performance, scalability, and environmental friendlin...
Rational design of high-loading electrocatalytic electrodes: from static multiscale integration to dynamic intelligent systems [0.03%]
高负载电催化电极的理性设计：从静态多尺度整合到动态智能系统
Zijing Suo,Yuyao Sun,Jianping Lai et al.
Zijing Suo et al.
In the field of electrocatalysis, the industrial application of high-loading electrodes faces a fundamental contradiction: traditional designs based on static structures struggle to match the dynamically changing reactive microenvironment a...
Radical-promoted "unstrained" C-C and C-N bond cleavage: a blueprint for deconstructive skeletal editing [0.03%]
自由基促进的“非张力”C-C和C-N键断裂：“解构式骨架编辑”的蓝图
José Justicia,Sara P Morcillo
José Justicia
Unstrained cyclic scaffolds are commonly regarded as inert backbones; however, recent radical and radical-ion strategies show that their connectivity can be deliberately reprogrammed when appropriate functional gateways are embedded in the ...
Functional group translocation: moving functionalities without changing molecular scaffolds [0.03%]
功能团迁移：在不改变分子支架的情况下移动官能团
Eito Moriya,Junichiro Yamaguchi
Eito Moriya
Functional group position plays a decisive role in molecular properties and function, with even subtle positional changes leading to pronounced differences in biological activity, material performance, and reactivity. Access to positional i...