The number of nuclei in compacted embryos, assessed by optical coherence microscopy, is a non-invasive and robust marker of mouse embryo quality [0.03%]
通过光学相干显微镜评估的紧缩胚胎中的核数目是衡量小鼠胚胎质量的一种非侵入性和健壮的指标
Aleksandra Sobkowiak,Monika Fluks,Ewa Kosyl et al.
Aleksandra Sobkowiak et al.
Optical coherence microscopy (OCM) visualizes nuclei in live, unlabeled cells. As most cells are uninucleated, the number of nuclei in embryos may serve as a proxy of the cell number, providing important information on developmental status ...
Sperm DNA methylation defects in a new mouse model of the 5,10-methylenetetrahydrofolate reductase 677C>T variant and correction with moderate dose folic acid supplementation [0.03%]
5,10-亚甲基四氢叶酸还原酶677C>T变异的新小鼠模型中的精子DNA甲基化缺陷以及中剂量叶酸补充的校正
Edgar Martínez Duncker Rebolledo,Donovan Chan,Karen E Christensen et al.
Edgar Martínez Duncker Rebolledo et al.
5,10-Methylenetetrahydrofolate reductase (MTHFR) is an enzyme that plays a key role in providing methyl groups for DNA methylation, including during spermatogenesis. A common genetic variant in humans (MTHFR 677C>T) results in reduced enzym...
Differential role of bovine serum albumin and HCO3- in the regulation of GSK3 alpha during mouse sperm capacitation [0.03%]
牛血清白蛋白和HCO3-在小鼠精子获能期间对GSK3 alpha调节中的不同作用
Gayatri Mohanty,Claudia Sanchez-Cardenas,Bidur Paudel et al.
Gayatri Mohanty et al.
To become fertile, mammalian sperm are required to undergo capacitation in the female tract or in vitro in defined media containing ions (e.g. HCO3 -, Ca2+, Na+, and Cl-), energy sources (e.g. glucose, pyruvate) and serum albumin (e.g. bovi...
Dysregulation of mucosal-associated invariant T cells correlates with altered placental microenvironment in preterm birth [0.03%]
黏膜相关不变T细胞的失调与早产中胎盘微环境的改变有关
Mi Wu,Fei Li,Ting Zhou et al.
Mi Wu et al.
Preterm birth (PTB) is a major problem affecting perinatal health, directly increasing the mortality risk of mother and infant that often results from the breakdown of the maternal-fetal immune balance. Increasing evidence shows the essenti...
Comprehensive analysis of ovarian granulosa cell proteomics and phosphoproteomics in PCOS patients without insulin resistance [0.03%]
多囊卵巢综合征患者无胰岛素抵抗的卵泡颗粒细胞蛋白质组学和磷酸化蛋白质组学的综合分析
Xiao Yang,Peng Liu,Hongcheng He et al.
Xiao Yang et al.
PCOS is a complex and heterogeneous metabolic disorder that affects 6-20% of women of reproductive age. However, research on phosphorylation modification proteomics in PCOS remains lacking. PCOS can be divided into two groups based on the p...
Racial disparity in uterine leiomyoma: new insights of genetic and environmental burden in myometrial cells [0.03%]
子宫平滑肌瘤中的种族差异：肌层细胞遗传和环境负担的新见解
Nazeer H Khan,Ross McNally,J Julie Kim et al.
Nazeer H Khan et al.
Uterine leiomyoma (LM), also known as uterine fibroids, are common gynecological tumors and can reach a prevalence of 70% among women by the age of 50 years. Notably, the LM burden is much higher in Black women with earlier onset, a greater...
O-GlcNAcylation orchestrates porcine oocyte maturation through maintaining mitochondrial dynamics and function [0.03%]
O-糖基化通过维持猪卵母细胞的线粒体动态和功能来主导其成熟过程
Wen-Jie Xiong,Xin-Le Lai,Jie Lu et al.
Wen-Jie Xiong et al.
O-linked β-N-acetylglucosamine (O-GlcNAc) modification exists widely in cells, playing a crucial role in the regulation of important biological processes such as transcription, translation, metabolism, and the cell cycle. O-GlcNAc modifica...
Deleterious variants in X-linked RHOXF1 cause male infertility with oligo- and azoospermia [0.03%]
X染色体上RHOXF1基因的有害变异会导致少精子症和无精子症引起的男性不育
Sibing Yi,Weili Wang,Lilan Su et al.
Sibing Yi et al.
Oligozoospermia and azoospermia are two common phenotypes of male infertility characterized by massive sperm defects owing to failure of spermatogenesis. The deleterious impact of candidate variants with male infertility is to be explored. ...
Antioxidant sericin averts the disruption of oocyte-follicular cell communication triggered by oxidative stress [0.03%]
抗氧化丝素避免氧化应激引起的卵母细胞-颗粒细胞间通讯紊乱
Hafiza Khatun,Ken-Ichi Yamanaka,Satoshi Sugimura
Hafiza Khatun
Antioxidants are free radical scavengers that increase oocyte quality and improve female fertility by suppressing oxidative stress. However, the related mechanisms remain unclear. The present study was designed to examine whether a reductio...
Addition of rapamycin or co-culture with cumulus cells from younger reproductive age women does not improve rescue in vitro oocyte maturation or euploidy rates in older reproductive age women [0.03%]
雷帕霉素的添加或与年轻女性的冠丘细胞共培养并不能提高年长女性体外卵母细胞成熟和整倍体率 Rescue Rate
Marga Esbert,Xin Tao,Agustín Ballesteros et al.
Marga Esbert et al.
Both spontaneously conceived pregnancies and those achieved using assisted reproduction decline with advancing maternal age. In this study, we tested if rapamycin and/or cumulus cells (CCs) from young donors could improve oocyte maturation ...
Randomized Controlled Trial
Molecular human reproduction. 2024 Feb 1;30(2):gaad048. DOI:10.1093/molehr/gaad048 2024