Maturational competence of equine oocytes is associated with alterations in their 'cumulome' [0.03%]
与卵母细胞的“Cumulome”变化相关的马卵母细胞发育成熟能力的研究
Jasmin Walter,Silvia Colleoni,Giovanna Lazzari et al.
Jasmin Walter et al.
Assisted reproductive technologies are an emerging field in equine reproduction, with species-dependent peculiarities, such as the low success rate of conventional IVF. Here, the 'cumulome' was related to the developmental capacity of its c...
Adjusting methylation levels with nucleus proportions highlights functional significance of differentially methylated cytosines associated with pre-eclampsia [0.03%]
使用核素比例调整甲基化水平以突出与子痫前期相关的差异性甲基化胞嘧啶的功能意义
Xiaoguo Zheng,Yanqin Wen,Xinzhi Zhao
Xiaoguo Zheng
Studies on DNA methylation alterations associated with pre-eclampsia (PE) have improved our understanding of the mechanisms underlying this disorder. However, differentially methylated cytosines (DMCs) have not been adjusted for cell-type h...
Variants in NLRP2 and ZFP36L2, non-core components of the human subcortical maternal complex, cause female infertility with embryonic development arrest [0.03%]
NLRP2和ZFP36L2基因变异导致胚胎发育停滞型女性不孕症
Ximan Rui,Xiaolan Zhang,Xinru Jia et al.
Ximan Rui et al.
The subcortical maternal complex (SCMC), which is vital in oocyte maturation and embryogenesis, consists of core proteins (NLRP5, TLE6, OOEP), non-core proteins (PADI6, KHDC3L, NLRP2, NLRP7), and other unknown proteins that are encoded by m...
Reply 2: Correlation between high FSH levels and increased risk of aneuploidy: the origin of the hypothesis [0.03%]
来信回复 2：高FSH水平与非整倍体风险增加之间的关系：假说的起源
Lori R Bernstein,Amelia C L Mackenzie,Charles L Chaffin et al.
Lori R Bernstein et al.
Reply 1: Correlation between high FSH levels and increased risk of aneuploidy: the origin of the hypothesis [0.03%]
来信回复：高水平FSH与非整倍体风险增加的相关性：假说的起源
Jose Buratini,Mariabeatrice Dal Canto,Mario Mignini Renzini et al.
Jose Buratini et al.
Obesity-associated non-oxidative genotoxic stress alters trophoblast turnover in human first-trimester placentas [0.03%]
肥胖相关非氧化性致突变压力改变人类早期胎盘滋养细胞更新
Denise Hoch,Alejandro Majali-Martinez,Julia Bandres-Meriz et al.
Denise Hoch et al.
Placental growth is most rapid during the first trimester (FT) of pregnancy, making it vulnerable to metabolic and endocrine influences. Obesity, with its inflammatory and oxidative stress, can cause cellular damage. We hypothesized that ma...
Oocyte-specific EXOC5 expression is required for mouse oogenesis and folliculogenesis [0.03%]
EXOC5的卵母细胞特异性表达对小鼠卵泡发生及卵母细胞发育是必需的
Hongwen Wu,Hieu Nguyen,Prianka H Hashim et al.
Hongwen Wu et al.
EXOC5 is a crucial component of a large multi-subunit tethering complex, the exocyst complex, that is required for fusion of secretory vesicles with the plasma membrane. Exoc5 deleted mice die as early embryos. Therefore, to determine the r...
The timing of pronuclear transfer critically affects the developmental competence and quality of embryos [0.03%]
卵核移植的时机影响胚胎的发育潜能和质量
Tereza Znachorova,Nataliia Dudko,Hao Ming et al.
Tereza Znachorova et al.
Pronuclear transfer has been successfully used in human-assisted reproduction to suppress the adverse effects of a defective oocyte cytoplasm or to bypass an idiopathic developmental arrest. However, the effects of the initial parental geno...