Vitamin D receptor in intrauterine adhesion: a hypothesis-driven review of potential roles and mechanistic insights [0.03%]
维生素D受体在宫腔粘连中的作用及其潜在机制的假设驱动综述
Min Yong,Xianghong Pu
Min Yong
Intrauterine adhesion (IUA) is a fibrotic disorder of the endometrium associated with menstrual disturbance, infertility, recurrent pregnancy loss, and adverse obstetric outcomes. Although surgical adhesiolysis remains the main treatment, r...
Androgen signalling is dispensable for fetal testis formation: Decoupling testis organogenesis from fetal masculinization programming [0.03%]
雄激素信号通路在胎儿睾丸形成中可有可无：解耦睾丸器官生成与男性化编程
Caroline Despicht,Anna O Bindel,Anna K Rosenmai et al.
Caroline Despicht et al.
Androgen receptor (AR) signalling is central to male sexual differentiation. Notably, however, fetal testis formation and androgen-dependent masculinization are temporally and mechanistically distinct processes that are not always clearly d...
The miRNA-coordinated synergism for placental gene regulation throughout pregnancy [0.03%]
贯穿整个孕期协调一致的miRNA协同作用调控胎盘基因表达
Caio I S Braga,Gisele Gouveia,Rayssa Feitosa et al.
Caio I S Braga et al.
The regulation of gene expression by microRNAs (miRNAs) is essential during development. However, it is necessary to move beyond individual miRNAs to understand their functions and the intricate interplay as a coordinated system. To address...
PRRC2A deficiency disrupts m6A-dependent RNA processing and meiosis in human spermatogenesis [0.03%]
PRRC2A缺乏通过干扰人类精子发生中mRNA去修饰和减数分裂导致不育
Hui Yu,Na Zhang,Xueping Liu et al.
Hui Yu et al.
The formation of N6-methyladenosine (m6A) is the most prevalent internal RNA modification in eukaryotic transcripts and plays an essential role in spermatogenesis. PRRC2A is a m6A reader that is indispensable for meiotic progression and is ...
Small Molecule Ovastacin Inhibitors Preserve Fertilization Competence of Murine Eggs by Mimicking Fetuin-B Function [0.03%]
小分子卵泡刺激素抑制剂通过模拟胎盘蛋白B功能来保持小鼠卵子的受精能力
Nele von Wiegen,Larissa Schömbs,Aleksander Moldt Haack et al.
Nele von Wiegen et al.
Infertility represents a major global health challenge and has driven increasing reliance on ART. However, fertilization success in vitro is often limited when physiological egg-sperm interaction is preserved, largely due to premature harde...
Placental plasminogen activator inhibitor 1 is induced by platelet-derived TGF-β independently of TGF-β receptor 3 and is upregulated in preeclampsia [0.03%]
胎盘组织型纤溶酶原激活物抑制剂1由血小板转化生长因子-β诱导，独立于TGF-β受体3，并在子痫前期中上调
Désirée Forstner,Azra Kulovic-Sissawo,Freya Lyssy et al.
Désirée Forstner et al.
Preeclampsia is a pregnancy complication associated with de novo gestational hypertension, proteinuria, and dysregulations in the coagulation and fibrinolytic systems. Platelet-derived factors include various growth and differentiation fact...
Proceedings of the 1st European Ovary Workshop (EOW 2025) Lagos, Portugal - February 17-20, 2025 [0.03%]
2025年欧洲卵巢 workshop会议 proceedings 纳贾尔，葡萄牙 2025年2月17-20日
Christiani A Amorim,Susana M Chuva De Sousa Lopes,Michael Klutstein et al.
Christiani A Amorim et al.
The inaugural European Ovary Workshop (EOW 2025), that was held on February 17-20, 2025 in Lagos, Portugal, brought together 165 scientists, clinicians, and early career researchers from 28 countries to advance ovarian biology from fundamen...
How Decidualization Dysregulation Reshapes the Nanomechanics of Endometrial Stromal Cells [0.03%]
蜕膜化失调如何重塑子宫内膜基质细胞的纳米力学性质
Ana Laura Schafir,Alejandra Marilina Fernandez,Laura Del Carmen Fernández et al.
Ana Laura Schafir et al.
Decidualization of endometrial stromal cells is a critical process for establishing uterine receptivity and successful embryo implantation, involving coordinated biochemical, cellular, and biomechanical remodeling. Emerging evidence indicat...
The post-reproductive ovary shifts from a reproductive to an immune-like organ [0.03%]
绝经后卵巢从生殖器官转变为类似免疫器官
Aubrey Converse,Shweta S Dipali,Ian P Schowe et al.
Aubrey Converse et al.
Reproductive aging in females is characterized by the irreversible depletion of ovarian follicles, yet the structure and function of the post-reproductive ovary remain poorly defined. Using paired histological and bulk transcriptomic analys...
Effects of changes in fat metabolism by particulate matter on endometrium and infertility [0.03%]
颗粒物通过改变脂代谢影响子宫内膜和不孕的作用及机制研究
Gee Soo Jung,Inha Lee,Hyunho Koo et al.
Gee Soo Jung et al.
Particulate matter (PM) exposure has been increasingly linked to metabolic and reproductive disorders, yet the mechanisms through which PM-related metabolic alterations influence endometrial function remain incompletely understood. In this ...