Temporal dynamics of uterine immune microenvironment remodeling in a murine model of adenomyosis [0.03%]
小鼠子宫腺肌病模型中子宫免疫微环境重塑的动态变化特征研究
Marlyne Squatrito,Julie Vervier,Laëtitia Bernet et al.
Marlyne Squatrito et al.
Adenomyosis-the ectopic presence of endometrial glands and stroma within the myometrium-affects reproductive-age women and is associated with pain, bleeding, and subfertility, yet the immune events that precede pregnancy remain poorly defin...
Beyza Gaye Edepli,Aylin Yaba
Beyza Gaye Edepli
Ovarian fibrosis is increasingly recognized as a pivotal factor contributing to ovarian aging, dysfunction and female infertility. It results from chronic or repetitive ovarian injury, such as that caused by repeated ovulation, which induce...
An Nlrp5-null mutation leads to attenuated de novo methylation in oocytes, accompanied by a significant reduction in DNMT3L [0.03%]
Nlrp5基因缺陷导致卵母细胞从头甲基化减弱及DNMT3L表达显著降低
Leah Nic Aodha,Alexandra Pokhilko,Leah U Rosen et al.
Leah Nic Aodha et al.
Nlrp5 encodes a core component of the subcortical maternal complex (SCMC) a cytoplasmic protein structure unique to the mammalian oocyte and cleavage-stage embryo. NLRP5 mutations have been identified in patients presenting with early embry...
Phosphorylation of YWHAZ at Serine 58 by PKB/Akt is associated with resumption of meiotic arrest in mouse oocytes [0.03%]
AKT丝氨酸58位对YWHAZ的磷酸化与小鼠卵母细胞减数分裂阻滞释放有关
Jianchao Huo,Yifan Zhao,Zengyou Ma et al.
Jianchao Huo et al.
Mammalian oocyte maturation is a tightly regulated process essential for successful fertilisation and embryonic development. Meiotic resumption in mammalian oocytes is controlled by various regulatory factors, including the tyrosine 3-monoo...
Melatonin Enhances Vitrified Mouse Blastocyst Development by Mitigating Oxidative Stress and Preserving Mitochondrial Function [0.03%]
褪黑素通过减轻氧化应激和维持线粒体功能来增强小鼠囊胚的玻璃化发育能力
Dan Zhou,Qiaoyu Chen,Yunlong Bai et al.
Dan Zhou et al.
This study aimed to investigate the benefits of melatonin supplementation during blastocyst vitrification and thawing process and explore underlying mechanisms to prevent apoptotic event. We evaluated blastocysts in three groups: fresh blas...
Molecular mechanisms of ligustilide in the treatment of low endometrial receptivity: involvement of Desmoglein-2 [0.03%]
当归apiin通过影响脱硫酸基化内皮素-1和子宫细胞凋亡改善子宫内膜接受性分子机制研究
Dongjie He,Xingxing Ren,Jing Mao et al.
Dongjie He et al.
We have previously shown that ligustilide (LIG) treatment can restore endometrial receptivity and promote implantation in pregnant rats with low endometrial receptivity (LER). By mRNA sequencing technology, we found that desmoglein-2 (Dsg2)...
Advances in non-essential testis-enriched genes for human and mouse spermatogenesis [0.03%]
人类和小鼠精子发生的非必需睾丸丰富基因的新进展
Chunjia Wei,Sibing Yi,Yaoqiong Liang et al.
Chunjia Wei et al.
Spermatogenesis is a highly complex cellular differentiation process. Recent advances employing knockout or knock-in mouse models have functionally characterized more than 700 genes as essential for male fertility maintenance. Paradoxically...
A Review on macrophage biology and its potential role in spontaneous abortion [0.03%]
巨噬细胞生物学及其在自然流产中潜在作用的研究进展
Xiaoxuan Zhao,Xinyi Ding,Qingnan Fan et al.
Xiaoxuan Zhao et al.
Spontaneous abortion (SA) is a challenging and frustrating obstetric complication. Immune dysregulation at the mother-fetal interface has long been recognized as a threat to pregnancy maintenance. Decidual macrophages are key gatekeepers fo...
TGFB1/SMAD3-Driven Macrophage-Myofibroblast Transition Promotes Fibrosis Progression in Endometriosis [0.03%]
TGFB1/SMAD3驱动的巨噬细胞肌成纤维细胞转化促进子宫内膜异位症纤维化进程
Yuchan Zhong,Xin Huang,Yujing Li et al.
Yuchan Zhong et al.
Endometriosis is a chronic gynecological disorder characterized by progressive fibrosis, which is closely associated with clinical symptoms such as dysmenorrhea and infertility. While myofibroblast activation is central to fibrogenesis, the...