Down-regulation of IGFBP2 mediates endometrial epithelial cells senescence in thin endometrium [0.03%]
IGFBP2低表达介导薄型子宫内膜上皮细胞衰老
Zihan Zhou,Zhenhua Zhou,Chunying Ye et al.
Zihan Zhou et al.
Thin endometrium (TE) is generally recognized as a contributing factor to reduced pregnancy rates and adverse perinatal outcomes, yet the pathogenesis of the disease remains elusive. We conducted an analysis and validation of the single-cel...
McKenna J Crossen,Shuai Jia,Joan S Jorgensen et al.
McKenna J Crossen et al.
The Wolffian duct (WD) is the embryonic primordium that gives rise to the epididymis, vas deferens and seminal vesicle. The androgen action in the mesenchyme is the predominant driver for fetal WD maintenance, which is essential for male fe...
Fertility is compromised after oocyte-specific deletion of microtubule severing protein katanin A1 [0.03%]
卵细胞特异性删除微管切割蛋白katanin A1会损害受孕率
Wai Shan Yuen,Qing-Hua Zhang,Monique Dunstan et al.
Wai Shan Yuen et al.
Katanins are microtubule severing enzymes that play roles in diverse cell functions including meiotic and mitotic spindle formation. To address the role of Katanin p60 isozymes in mammalian oocytes, we have used the ZP3-CreLox approach to s...
Identification of transcription factors that regulate placental sFLT1 expression [0.03%]
鉴定调控胎盘sflt1表达的转录因子
Qing Yong,Carin van der Keur,Jacqueline D H Anholts et al.
Qing Yong et al.
Increased sFLT1 levels have been associated with preeclampsia, chronic kidney diseases, and kidney transplant rejection. However, lower levels of sFLT1 exhibit beneficial properties in various processes, such as organization of the actin cy...
WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Heterologous): heterologous rodent models [0.03%]
外异体动物模型的子宫内膜异位症表型和生物库协调项目（EPHect-EM-Heterologous）：异种啮齿类动物模型
M Louise Hull,Raul Gomez,Warren B Nothnick et al.
M Louise Hull et al.
Endometriosis, defined as the growth of endometrial-like tissues outside the uterus, is a common disease among women. Numerous in vivo rodent models of endometriosis have been developed to explore multiple aspects of this poorly understood ...
WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Organoids): endometrial organoids as an emerging technology for endometriosis research [0.03%]
外阴痕形成表型和生物信息库协调项目（EPHect-EM-类器官）：子宫内膜类器官作为研究子宫内膜的新技术
Elizabeth E Marr,Juan S Gnecco,Stacey A Missmer et al.
Elizabeth E Marr et al.
The aetiology of endometriosis remains poorly understood. In vitro model systems provide the opportunity to identify the mechanisms driving disease pathogenesis using human cells. Three-dimensional models, particularly organoid systems, hav...
WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Homologous): homologous rodent models [0.03%]
子宫内膜异位症表型和生物样本库协调项目（EPHect-EM-Homologous）：同种动物模型在子宫内膜异位症研究中的应用
Katherine A Burns,Daniëlle Peterse,Caroline B Appleyard et al.
Katherine A Burns et al.
In vivo models of endometriosis enable the discovery and preclinical testing of new therapies. Several rodent models of endometriosis exist, but a lack of harmonization impedes reproducibility and comparability of results among investigator...
WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Pain): methods to assess pain behaviour in rodent models of endometriosis [0.03%]
内异症研究中实验模型的内异症表型和生物信息库协调项目（EPHect-EM-Pain）：评估内异症动物模型疼痛行为的方法学
Kelsi N Dodds,Victor Fattori,Nick A Andrews et al.
Kelsi N Dodds et al.
Pain is a debilitating symptom of endometriosis, and its mechanisms are often explored using rodent models. However, a lack of harmonization amongst models and behavioural measures, in addition to inconsistent reporting, might limit the ove...
Enhancing collaboration in endometriosis research through the initiative of the World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonisation Project (EPHect) [0.03%]
世界子宫内膜异位症研究基金会子宫内膜异位症表型和生物信息库协调项目（EPHect）通过发起倡议促进子宫内膜异位症研究中的合作
Lone Hummelshoj,Daniëlle Peterse,Kaylon L Bruner-Tran et al.
Lone Hummelshoj et al.
TTBK2 affects sperm quality by regulating the expression of centrosomal proteins and flagellar transporters during spermiogenesis in mice [0.03%]
TBRK2通过调节小鼠精子生成过程中中心体蛋白和鞭毛转运蛋白的表达影响精子质量
Tianqing Chang,Hua Wu,Xinyue Zhang et al.
Tianqing Chang et al.
Sperm plays a crucial role in male reproduction and only a certain number of normal progressive sperm can achieve oocyte fertilization. Revealing the regulatory mechanism of spermatogenesis will help to clarify the pathogenesis of male infe...