Activation of TRPV4 stimulates transepithelial K+ secretion in rat epididymal epithelium [0.03%]
TRPV4激活可刺激雄性大鼠附睾上皮的经上皮K+分泌作用
Dong-Dong Gao,Jun-Hao Huang,Yi-Lin Zhang et al.
Dong-Dong Gao et al.
The maturation of sperms is dependent on the coordinated interactions between sperm and the unique epididymal luminal milieu, which is characterized by high K+ content. This study investigated the involvement of transient receptor potential...
DNA repair and response to sperm DNA damage in oocytes and embryos, and the potential consequences in ART: a systematic review [0.03%]
卵子和胚胎中针对精子DNA损伤的修复及反应及其在辅助生殖技术中的潜在后果：系统综述
H Newman,S Catt,B Vining et al.
H Newman et al.
Sperm DNA damage is considered a predictive factor for the clinical outcomes of patients undergoing ART. Laboratory evidence suggests that zygotes and developing embryos have adopted specific response and repair mechanisms to repair DNA dam...
Expression profiling and function analysis identified new microRNAs regulating cumulus expansion and apoptosis in cumulus cells [0.03%]
表达谱分析及功能分析鉴定新的microRNA并揭示其通过调节放射冠细胞的扩展和凋亡来影响卵母细胞成熟的作用机制
Xiao Han,Min Zhang,Hong-Jie Yuan et al.
Xiao Han et al.
Although microRNAs (miRNAs) expressed in cumulus cells (CCs) may be used to select competent oocytes/embryos, only a limited number of such miRNAs has been reported. To identify more miRNAs that regulate cumulus expansion (CE) and CC apopto...
Molecular mechanisms in IL-1β-mediated decorin production by decidual cells [0.03%]
蜕膜细胞介导的IL-1β调节Decorin分子机制研究
C D Halari,S J Renaud,P K Lala
C D Halari
Decorin, a small leucine-rich proteoglycan produced by decidual cells restrains trophoblast differentiation, migration and invasiveness of extra-villous trophoblast cells. Decidual overproduction of decorin is associated with preeclampsia, ...
Single-cell RNA sequencing reveals abnormal fluctuations in human eight-cell embryos associated with blastocyst formation failure [0.03%]
单细胞RNA测序揭示人类早期胚胎八细胞期的异常波动与囊胚发育失败相关性
Qi-Long He,Peng Yuan,Lu Yang et al.
Qi-Long He et al.
Infertility has become a global health issue, with the number of people suffering from the disease increasing year by year, and ART offering great promise for infertility treatment. However, the regulation of early embryonic development is ...
Suppression of uterine and placental ferroptosis by N-acetylcysteine in a rat model of polycystic ovary syndrome [0.03%]
N-乙酰半胱氨酸在多囊卵巢综合征大鼠模型中对子宫和胎盘铁死亡的抑制作用
Min Hu,Yuehui Zhang,Shuting Ma et al.
Min Hu et al.
The mechanisms that link hyperandrogenism and insulin (INS) resistance (HAIR) to the increased miscarriage rate in women with polycystic ovary syndrome (PCOS) remain elusive. Previous studies demonstrate that increased uterine and placental...
Comparative Study
Molecular human reproduction. 2021 Nov 27;27(12):gaab067. DOI:10.1093/molehr/gaab067 2021
Dissecting EPPIN protease inhibitor domains in sperm motility and fertilizing ability: repercussions for male contraceptive development [0.03%]
精子运动和受精能力中EPPIN蛋白酶抑制结构域的分析：对男性避孕药开发的影响
Alan A S Silva,Tamiris R F Raimundo,Noemia A P Mariani et al.
Alan A S Silva et al.
EPPIN (epididymal protease inhibitor) is a mammalian conserved sperm-binding protein displaying an N-terminal WFDC (whey-acidic protein four-disulfide core) and a C-terminal Kunitz protease inhibitor domains. EPPIN plays a key role in regul...
Hypoxia-inducible factor-1β is essential for upregulation of the hypoxia-induced FLT1 gene in placental trophoblasts [0.03%]
低氧诱导因子-1β对于胎盘滋养层细胞中低氧诱导的FLT1基因的表达上调是必不可少的
Tadashi Sasagawa,Takeshi Nagamatsu,Manami Yanagisawa et al.
Tadashi Sasagawa et al.
Placental hypoxia and increased levels of maternal blood anti-angiogenic protein, soluble fms-like tyrosine kinase-1 (sFLT1), are associated with the pathogenesis of pre-eclampsia. We have demonstrated that hypoxia-inducible factor (HIF)-2...
G-CSF and IL-6 may be involved in formation of endometriosis lesions by increasing the expression of angiogenic factors in neutrophils [0.03%]
G-CSF和IL-6可能通过增加中性粒细胞的促血管生成因子的表达而参与子宫内膜异位症病灶的形成
Fang Guo,Yongpei He,Yixian Fan et al.
Fang Guo et al.
Evidence accumulated in recent years has revealed that neutrophils are involved in the initial establishment of endometriosis, which is well-known as a chronic inflammatory disease. So far, why and how neutrophils promote the formation of e...
HENMT1 is involved in the maintenance of normal female fertility in the mouse [0.03%]
HENMT1参与维持小鼠正常的女性生育能力
Karla J Hutt,Shu Ly Lim,Qing-Hua Zhang et al.
Karla J Hutt et al.
PIWI-interacting small RNAs (piRNAs) maintain genome stability in animal germ cells, with a predominant role in silencing transposable elements. Mutations in the piRNA pathway in the mouse uniformly lead to failed spermatogenesis and male s...