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Comparative Study Molecular human reproduction. 2021 Nov 27;27(12):gaab067. doi: 10.1093/molehr/gaab067 Q13.52025

Suppression of uterine and placental ferroptosis by N-acetylcysteine in a rat model of polycystic ovary syndrome

N-乙酰半胱氨酸在多囊卵巢综合征大鼠模型中对子宫和胎盘铁死亡的抑制作用 翻译改进

Min Hu  1  2  3, Yuehui Zhang  3  4, Shuting Ma  4, Juanli Li  4, Xu Wang  4, Mengmeng Liang  4, Amanda Nancy Sferruzzi-Perri  5, Xiaoke Wu  4, Hongxia Ma  1  2, Mats Brännström  6, Linus R Shao  3, Håkan Billig  3

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作者单位

  • 1 Department of Traditional Chinese Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
  • 2 Institute of Integrated Traditional Chinese Medicine and Western Medicine, Guangzhou Medical University, Guangzhou, China.
  • 3 Department of Physiology and Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • 4 Department of Obstetrics and Gynecology, Key Laboratory and Unit of Infertility in Chinese Medicine, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China.
  • 5 Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
  • 6 Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

    • DOI: 10.1093/molehr/gaab067 PMID: 34850077

    摘要 Ai翻译

    The mechanisms that link hyperandrogenism and insulin (INS) resistance (HAIR) to the increased miscarriage rate in women with polycystic ovary syndrome (PCOS) remain elusive. Previous studies demonstrate that increased uterine and placental ferroptosis is associated with oxidative stress-induced fetal loss in a pre-clinical PCOS-like rat model. Here, we investigated the efficacy and molecular mechanism of action of the antioxidant N-acetylcysteine (NAC) in... ...点击完成人机验证后继续浏览
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    期刊名：Molecular human reproduction

    缩写：MOL HUM REPROD

    ISSN：1360-9947

    e-ISSN：1460-2407

    IF/分区：3.5/Q1

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    Suppression of uterine and placental ferroptosis by N-acetylcysteine in a rat model of polycystic ovary syndrome