Super-Enhancer-Mediated DLX5 Activation Defines Regulatory Mechanisms in Human Embryonic Stem Cell-Derived Osteoblasts [0.03%]
超级增强子介导的DLX5激活定义了人胚胎干细胞来源成骨细胞中的调控机制
Shinse Fujita,Shoichiro Tani,Hiroyuki Okada et al.
Shinse Fujita et al.
Osteoblast differentiation is essential for skeletal development and homeostasis. Although bone marrow-derived mesenchymal stem/stromal cells (BM-MSCs) are commonly used to study osteoblast differentiation in the context of bone homeostasis...
Histone Demethylation Activity of UTX Contributes to the Regulation of Steroid Biosynthesis Genes in Embryonic Gonads but Is Dispensable for Gonadal Sex Determination [0.03%]
UTX组蛋白去甲基化活性调节胚胎性腺固醇生物合成基因表达但在性别决定中非必需
Mio Kojima,Mayu Fujita,Tokuko Iwamori et al.
Mio Kojima et al.
Mammalian sex is determined by the presence or absence of a Y chromosome. The sex-specific features of each cell and tissue in the body then develop in response to the sex hormones secreted by the differentiated reproductive tissues. Both t...
Cell Tracing by a Multicolor Reporter Transgenic Iberian Ribbed Newt Pleurodeles waltl [0.03%]
多色报告转基因伊比利亚肋足新薯蟾(Pleurodeles waltl)细胞追踪
Shinichi Hayashi,Ryohei Seki-Omura,Yuki Sato et al.
Shinichi Hayashi et al.
Living organisms exhibit varying regenerative abilities depending on the species. Among them, urodele amphibians have been widely used in regeneration biology due to their remarkable regenerative capacity. Iberian ribbed newts, in particula...
Foxg1 and Retinoic Acid Signaling Regulate Zonal Patterning in the Developing Olfactory Epithelium [0.03%]
FOXG1和视黄酸信号调控嗅上皮区域模式形成
Anzu Kuriyama,Carina Hanashima
Anzu Kuriyama
Odor information processing begins in the olfactory epithelium (OE), which in mice is spatially divided into two zones: the dorsomedial zone (D-zone), responsible for innate aversive behaviors, and the ventrolateral zone (V-zone), associate...
Unveiling the Molecular Pathogenesis of MCPH: Insights From Drosophila Model System [0.03%]
MCPH分子病理机制的阐释——来自果蝇模型系统的启示
Degisew Yinur Mengistu
Degisew Yinur Mengistu
Primary microcephaly (MCPH) is a rare genetic neurodevelopmental disorder caused by homologous recessive mutations of the MCPH genes. It manifests as a significant reduction in brain volume and intellectual disability at birth. More than 28...
Seiji Saito,Nobuyuki Hibino,Momoko Kyu-Shin et al.
Seiji Saito et al.
One of the most widely used methods for phenotypic analysis in developmental biology is whole-mount skeletal staining of mice. In this method, cartilage and bone are stained using two types of reagents, Alcian blue and Alizarin red, to obse...
Universal Improvement of In Situ Hybridization Chain Reaction by Reducing Background Signals Caused by Single Probes [0.03%]
通过减少单个探针引起的背景信号普遍改善原位放大杂交反应
Yudai Kuboe,Kensuke Nakanishi,Ichiro Tazawa et al.
Yudai Kuboe et al.
The in situ hybridization chain reaction (HCR) method involves designing multiple target sequences and a pair of split probes for each target. One split probe contains the complementary sequence for half of the target along with part of the...
Yui Uchida,Tasuku Ishida,Satomi Ono et al.
Yui Uchida et al.
The official poster for the First Evo-Devo Young Researchers Meeting. It features the meeting title, themes ("Evo-Devo so far" and "Evo-Devo in the future"), invited speakers, program highlights, and logistical details. The content is writt...
GLI3 in Archaic Humans: Possible Contributions to Human Skeletal and Brain Evolution [0.03%]
尼安德特人中的GLI3基因：可能对人类骨骼和大脑进化的贡献
Tadashi Nomura,Ako Agata,Nguyen Thi My Trinh
Tadashi Nomura
Neanderthals, an extinct hominid, lived in Eurasia until about 40,000 years ago. According to fossils, Neanderthals had distinctive anatomical features compared to modern humans, including a long front-to-back cranium, low frontal bones, an...
Syncytin-1 Is Responsible for the Fusion Between Human Trophoblasts and Endometrial Stromal Cells [0.03%]
合体滋养层细胞和子宫内膜基质细胞融合由Syncytin-1介导
Akira Oike,Shun Shibata,Takahiro Arima et al.
Akira Oike et al.
Syncytiotrophoblasts (STs) are multinucleated cells formed by the fusion of trophoblasts and play critical roles in placental development and function. Retrovirus-derived fusogenic proteins, known as syncytins, regulate trophoblast fusion b...