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Histone Demethylation Activity of UTX Contributes to the Regulation of Steroid Biosynthesis Genes in Embryonic Gonads but Is Dispensable for Gonadal Sex Determination

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Mammalian sex is determined by the presence or absence of a Y chromosome. The sex-specific features of each cell and tissue in the body then develop in response to the sex hormones secreted by the differentiated reproductive tissues. Both the X and Y chromosom... ...