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Yi Zheng,Taoyi Chen,Valerie Vaissier Welborn Yi Zheng
Enzymes are reported to catalyze reactions by generating electric fields that promote the evolution of the reaction in the active site. Although seldom used outside enzymatic catalysis, electrostatic preorganization theory and the language ...
Glycoproteins, Glycolipids, or Both: Why do Glycosyltransferases Recognize Different Acceptors? [0.03%] 糖蛋白、糖脂或二者兼有：为什么糖基转移酶能识别不同的受体？
Krzysztof Mikołajczyk,Marcin Czerwinski,Radoslaw Kaczmarek Krzysztof Mikołajczyk
Glycosylation is an important post-translational modification catalyzed by glycosyltransferases (GTs), which comprise a large group of enzymes with diversified specificity. Most GTs show high specificity toward donor and acceptor molecules,...
Solomon K Attionu,Rita Dill,Michael F Summers et al. Solomon K Attionu et al.
RNAs regulate various cellular processes using malleable 3D structures, and understanding the factors that control RNA structure and dynamics is critical for understanding their mechanisms of action. To mitigate factors that have limited st...
Development of a Peptide Inhibitor Targeting the C-SH2 Domain of the SHP2 Phosphatase [0.03%] 针对SHP2磷酸酶C-SH2结构域的肽类抑制剂开发
Azin Kiani,Catia L Pierotti,Franziska Schedel et al. Azin Kiani et al.
Src homology 2 (SH2) domain-containing phosphatase 2 (SHP2) mediates important signal transduction upon cell surface receptor stimulation, regulating multiple cellular functions. In addition to the catalytically active phosphotyrosine (pTyr...
Clade III Synthases Add Cyclic And Linear Terpenoids To The Psilocybe Metabolome [0.03%] Clade III 合酶增加环状和线性萜类到裸盖菇代谢物库中
Nick Zschoche,Sebastian Schober,Karl Walther et al. Nick Zschoche et al.
Psilocybe "magic mushrooms" are best known for their indolethylamine psilocybin, yet they encode enzymes for a much more diverse arsenal of small and potentially bioactive molecules. Here, we report on four Psilocybe cubensis clade III sesq...
Hijacking the MDM2 E3 Ligase with novel BRD4-Targeting PROTACs in Pancreatic Cancer Cells [0.03%] 通过新型BRD4靶向PROTAC劫持MDM2 E3连接酶在胰腺癌细胞中的作用
Mihaela Ficu,Dan Niculescu-Duvaz,Mohammed Aljarah et al. Mihaela Ficu et al.
The phenotypic effect induced by a Proteolysis-Targeting Chimera (PROTAC) can depend on several factors, including the E3 ligase recruited. For the discovery of a first-in-class PROTAC for a target of interest, the E3 ligases commonly hijac...
Synthesis of 2-substituted ATP derivatives and their use in enzymatic synthesis and postsynthetic labelling of RNA [0.03%] 关于2-取代ATP衍生物的合成及其在酶催化RNA合成和非天然碱基蛋白质合成后的应用研究论文摘要
Ugnė Šinkevičiūtė,Tania Sanchez-Quirante,Samanta Rožánková et al. Ugnė Šinkevičiūtė et al.
A series of adenosine triphosphate derivatives bearing chloro, fluoro, amino, methyl, vinyl and ethynyl groups at position 2 were synthesized and tested as substrates for RNA and DNA polymerases. The modified nucleotides worked well in in v...
Chemically Synthesized Fluorescence based Kinase Sensing Systems for Signaling in Cancer [0.03%] 基于化学合成的荧光激酶传感系统在癌症信号传导中的应用
Anindita Roy,Monisha Singha,Subhankar Singha Anindita Roy
Kinases are an essential class of enzymes that regulate cellular processes through phosphorylation, influencing signal transduction, cell cycle progression, and apoptosis. Dysregulation of kinase activity is a hallmark of cancer, contributi...
Biosynthesis of Ephedrine is Initiated by Pyridoxal Phosphate-Dependent Formation of Cathinone [0.03%] 麻黄碱生物合成由依赖吡哆醛磷酸的咔藤因形成启动
Karina Witte,Anne Behrens,Hannes M Schwelm et al. Karina Witte et al.
Ephedra alkaloids possess some of the most basic structures of alkaloids. Despite their importance for human use and their commercial relevance, the biosynthesis of ephedra alkaloids has remained enigmatic. The predominant biosynthetic path...
Binding of Hg(I) and Hg(II) Ions to Amyloid-Beta (Aβ) Peptide Variants Affect Their Structure and Aggregation [0.03%] Hg(I)和Hg(II)离子与淀粉样β(Aβ)肽变体的结合会影响其结构和聚集性
Elina Berntsson,Andra Noormägi,Kärt Padari et al. Elina Berntsson et al.
Mercury (Hg) exposure is a possible risk factor for Alzheimer´s disease (AD). Some studies reported higher Hg levels in AD patients, but evidence is inconclusive. A mechanism linking Hg exposure to AD neuropathology remains to be found. Th...