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Synthesis and Evaluation of Trehalose-Based Mertansine Warheads for BCG Delivery of Anti-Cancer Agents [0.03%] 基于海藻糖的美坦辛弹头的合成与评价及其在抗癌药物BCG递送中的应用
Michael Grimmeisen,Xuan Wang,Melissa Weldle et al. Michael Grimmeisen et al.
Non-muscle invasive bladder cancer (NMIBC) accounts for 75% of bladder cancer cases, with Bacillus Calmette-Guérin (BCG) immunotherapy as the gold standard for high-risk patients. BCG elicits a robust immune response but is limited by adve...
Macromolecular High-Affinity Binding Probed by Advanced Fluorescence Techniques [0.03%] 先进的荧光技术探测大分子高亲和力结合现象
Alida Meyer,Benno Schedler,Joerg Fitter Alida Meyer
Due to the extreme sensitivity and the intrinsic selectivity of fluorescence techniques, high-affinity binding can be measured even at extremely low molecule concentrations in the picomolar range. In particular, modern advanced techniques w...
Assembly of Branched Chain Amino Acids to Toxic Fibrils may be Related to Pathogenesis of Maple Syrup Urine Disease [0.03%] 支链氨基酸自组装形成有毒原纤维可能与枫糖尿病发病机制有关
Chandra Kanth,Monisha Patel,Raj Dave et al. Chandra Kanth et al.
Inborn errors of metabolism (IEMs) lead to the buildup of metabolites that are typically toxic or disrupt normal cellular function. The etiological relation of metabolic disorders has been uncovered through the study of metabolite amyloids....
A tailored phospho-p53 library probes antibody specificity and recognition limitations [0.03%] 定制的磷酸化p53文库探测抗体特异性和识别限制
Mateusz Hess,Jonathan Davies,Sofia Margiola et al. Mateusz Hess et al.
The tumour suppressor protein p53, known as the "guardian of the genome", is regulated by a complex network of posttranslational modifications (PTMs). Phosphorylations at 7 Ser/Thr residues within the N-terminal transactivation domain 1 (TA...
Chemical Switching: A Concept Inspired by Strategies from Biocatalysis and Organocatalysis [0.03%] 由生物催化和有机催化策略启发的化学开关概念
Torkild Visnes,Kaixin Zhou,Aurino M Kemas et al. Torkild Visnes et al.
In this perspective the character of aldehyde functional groups is outlined as central intermediates in DNA repair. As highly reactive entities, aldehydes exist in limited quantities and in contextualized scenarios only and are commonly mas...
Structural Basis of Regioselective Bromination of Tricyclic Tryptoline by the Tryptophan Halogenase Thal [0.03%] 溴化三环色氨衍生物的区域选择性机制及其卤酶Thal的结构基础研究
Simon Bork,Caroline Besse,Norbert Sewald et al. Simon Bork et al.
Flavin-dependent halogenases (FDHs) carry out substrate-specific and regioselective halogenation reactions in the biosynthesis of various halogenated natural compounds. Several FDHs convert non-native substrates in vitro. However, obtaining...
Galactose-Functionalized Gold Nanoparticles Targeting Membrane Transporters for the Glutathione Delivery to Brain Cancer Cells [0.03%] 乙醇酸功能化的金纳米颗粒靶向膜转运蛋白递送谷胱甘肽到脑癌细胞中去
Francesca Milano,Alessia Nito,Annalisa Caputo et al. Francesca Milano et al.
Glutathione (GSH), a tripeptide essential for maintaining redox balance in the human body, plays a critical role in protecting cells from oxidative stress. A deficiency in GSH is linked to increased oxidative damage and the progression of v...
A Cyclized Helix-Loop-Helix Peptide as a Molecular Scaffold for Cell-Membrane Permeable Inhibitors for the Interaction between Estrogen Receptor α and Coactivator SRC1 [0.03%] 一种环化的肽类分子支架用于合成雌激素受体α与共激活因子SRC1相互作用的穿膜抑制剂
Daisuke Fujiwara,Shunsuke Inaura,Yuna Tanaka et al. Daisuke Fujiwara et al.
The molecular design of inhibitors against intracellular protein-protein interactions (PPIs) is of interest for drug discovery and chemical biology. Here, we designed a novel cyclized helix-loop-helix (cHLH) peptide that inhibited the intra...
Designing an Entactin-Inspired Short Bioactive Hydrogel as Biofunctional Scaffold [0.03%] 一种用于生物功能载体的类 entactin 短肽活性水凝胶的设计
Shambhavi Kashyap,Sweta Mohanty,Sourav Sen et al. Shambhavi Kashyap et al.
Self-assembled peptide hydrogels developed from bioactive domains of extracellular matrix (ECM) have shown great capabilities to mimic the structural and functional aspects of ECM. In this direction, we explored the self-assembling potentia...
Hazelnut: Explorations towards the biocatalytic synthesis of its aroma precursor [0.03%] 探究使用生物催化剂合成 hazelnut 风味前体分子的研究
Mireia Salvadó-Pau,Wolf-Dieter Fessner,Zvjezdana Findrik Blažević et al. Mireia Salvadó-Pau et al.
Biocatalysis has gained significant industrial interest due to its controlled stereoselectivity and use of mild process conditions. Here we propose a biosynthetic route for the synthesis of filbertone (5-methyl-2-hepten-4-one, 1), which is ...