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S-Adenosyl-d-Methionine as a Non-Physiological Substrate for a Wide Range of SAM-Dependent Enzymes

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The ability of SAM-dependent enzymes to accept S-adenosyl-d-methionine [d-SAM, (SS,RCα)-SAM] instead of the native cofactor S-adenosyl-l-methionine [l-SAM, (SS,SCα)-SAM] remains largely unexplored. Challenging the stereochemical preference of SAM-dependent e... ...