The efficacy and safety of omadacycline plus β-lactam versus moxifloxacin plus β-lactam for the treatment of severe community-acquired pneumonia: study protocol of a multicenter, prospective, randomized controlled non-inferiority trial [0.03%]
奥马环素联合β-内酰胺类与莫西沙星联合β-内酰胺类治疗严重社区获得性肺炎疗效和安全性的非劣效性多中心、前瞻性随机对照试验方案
Xin Zhang,Danyang She,Yinghui Shi et al.
Xin Zhang et al.
Background: Severe community-acquired pneumonia (sCAP) is associated with high morbidity and mortality. Current empirical antimicrobial regimens are increasingly challenged by rising antimicrobial resistance and safety co...
Lower hepatitis E clearance rates in thoracic organ recipients compared to visceral organ recipients: an effect of stronger immunosuppression? [0.03%]
与接受内脏器官移植的患者相比，接受胸部器官移植患者的慢性丙型肝炎病毒清除率更低：更强免疫抑制的结果？
Sven Pischke,L Kwoka,A Nolde et al.
Sven Pischke et al.
Background and aims: Hepatitis E virus (HEV) infection is a significant concern for solid organ transplant (SOT) recipients. However, the extent of this disease among recipients of different organs remains unclear. ...
Ebola virus disease in the modern era: pathogenesis, therapeutic advances, vaccine strategies, and global health preparedness [0.03%]
现代埃博拉病毒病：发病机制、治疗进展、疫苗策略和全球卫生准备状况
Dola Sundeep,Kovuri Umadevi,Jaweria Masood et al.
Dola Sundeep et al.
Ebola virus disease (EVD) remains one of the most severe and complex viral hemorrhagic fevers confronting global public health systems. Since its first recognized emergence in 1976, recurrent outbreaks caused primarily by Zaire ebolavirus h...
Lasse Fjordside,Anna Florescu,Al-Hasan Hussein Dos et al.
Lasse Fjordside et al.
Background: The persistent challenges with diagnosing Lyme neuroborreliosis (LNB) have fostered investigations in a broad spectrum of biomarker candidates. The aim of this systematic review is to provide a comprehensive o...
Chia-Yu Chiu,Mathew G Angelos,Shyam Raghavan
Chia-Yu Chiu
Acute respiratory distress syndrome in scrub typhus: a systematic review and meta-analysis [0.03%]
恙虫病急性呼吸窘迫综合征的系统评价和meta分析
Souvik Chaudhuri,Shreya Das Adhikari,Carl Boodman et al.
Souvik Chaudhuri et al.
Purpose: Acute respiratory distress syndrome (ARDS) is an important complication of scrub typhus and is associated with substantial mortality. The primary objective of this systematic review and meta-analysis was to estim...
Guenter Froeschl,Thomas Vogel,Leon Gehri et al.
Guenter Froeschl et al.
Purpose: We are reporting on a rare case of a primary manifestation of Alveolar Echinococcosis in the spleen in a German patient. Methods: ...
Mechanistic and molecular insights into emerging anti-virulence therapeutics [0.03%]
针对抗菌药物的新思路：抗毒力疗法的机制和分子机理展望
Ruchita Bhomia,Shruti Chatterjee
Ruchita Bhomia
Antimicrobial resistance (AMR) poses a global health crisis and necessitates novel therapeutic strategies beyond traditional antibiotic, driving interest in anti-virulence (AV) strategies that disable pathogenicity rather than bacterial via...
Stepwise breach of maternal-fetal fortress: an adhesion-degradation-immune evasion cascade underpinning Treponema pallidum placental crossing [0.03%]
分步破坏母胎堡垒：Treponema pallidum 跨胎盘屏障的粘附-降解-免疫逃逸级联反应
Guang Liu,Zhichao Deng,Hong Huang et al.
Guang Liu et al.
Congenital syphilis, a severe maternal-fetal disease caused by vertical transmission of Treponema pallidum (T. pallidum) via the placenta, affects over one million pregnancies annually and remains a leading cause of preventable adverse feta...
Caseload, treatment diagnoses, and evaluation of clinical care concepts for infectious diseases at a municipal tertiary care hospital in Germany [0.03%]
德国慕尼黑市三级医疗保健医院传染病病例、治疗诊断及临床护理概念评估
Kathrin Marx,Nils Kellner,Nadja Herrmann et al.
Kathrin Marx et al.
Background: Comprehensive data on municipal specialized infectious disease (ID) departments in Germany are scarce. Purpose: To analyze ...