PET imaging of Hsp90 expression in pancreatic cancer using a new 64Cu-labeled dimeric Sansalvamide A decapeptide [0.03%]
一种新的铜-64标记的链格孢菌酸A十肽Hsp90二聚物在胰腺癌中的热休克蛋白90表达正电子发射断层成像(PET)显影研究
Xiaohui Wang,Jun Zhang,Hubing Wu et al.
Xiaohui Wang et al.
Heat shock protein 90 (Hsp90) plays a vital role in the progress of malignant disease and elevated Hsp90 expression has been reported in pancreatic cancer. In this study, we radiolabeled a dimeric Sansalvamide A derivative (Di-San A1) with ...
Comparative phosphoproteomic analysis reveals differentially phosphorylated proteins regulate anther and pollen development in kenaf cytoplasmic male sterility line [0.03%]
comparative phosphoproteomics分析揭示了雄性不育棉花属细胞质线的花药和花粉发育过程中的差异磷酸化蛋白质
Peng Chen,Ru Li,Ruiyang Zhou
Peng Chen
Cytoplasmic male sterility (CMS) is widely used in plant breeding and represents a perfect model to understand cyto-nuclear interactions and pollen development research. Protein phosphorylation is ubiquitous and is involved in the regulatio...
Comparative Study
Amino acids. 2018 Jul;50(7):841-862. DOI:10.1007/s00726-018-2564-0 2018
Site-specific derivatization of human interferon β-1a at lysine residues using microbial transglutaminase [0.03%]
采用微生物转谷氨酰胺酶在人干扰素β-1a的赖氨酸残基上进行定点修饰
Barbara Spolaore,Giacomo Forzato,Angelo Fontana
Barbara Spolaore
Microbial transglutaminase (TGase) has been successfully used to produce site-specific protein conjugates derivatized at the level of glutamine (Gln) or lysine (Lys) residues with diverse applications. Here, we study the drug human interfer...
Nucleoprotein from the unique human infecting Orthobunyavirus of Simbu serogroup (Oropouche virus) forms higher order oligomers in complex with nucleic acids in vitro [0.03%]
一种独特的感染人的Simbu病毒群正链病毒属核糖核酸病毒（奥罗埔切病毒）的核蛋白在体外与核苷酸形成高阶寡聚物
Juliana Londoño Murillo,Aline Diniz Cabral,Mabel Uehara et al.
Juliana Londoño Murillo et al.
Oropouche virus (OROV) is the unique known human pathogen belonging to serogroup Simbu of Orthobunyavirus genus and Bunyaviridae family. OROV is transmitted by wild mosquitoes species to sloths, rodents, monkeys and birds in sylvatic enviro...
Taurine prevents ethanol-induced apoptosis mediated by mitochondrial or death receptor pathways in liver cells [0.03%]
牛磺酸通过线粒体和死亡受体途径预防酒精引起的肝细胞凋亡
Gaofeng Wu,Jiancheng Yang,Hao Lv et al.
Gaofeng Wu et al.
One pathogenic mechanism of ethanol-induced liver injury is the excessive production of reactive oxygen species (ROS), which may result in alcoholic liver disease (ALD) characterized by cell death due to necrosis and apoptosis. Taurine was ...
Short-chain consensus alpha-neurotoxin: a synthetic 60-mer peptide with generic traits and enhanced immunogenic properties [0.03%]
短链共识α-神经毒素：一种具有通用特征和增强免疫原性的合成六十余肽
Guillermo de la Rosa,Ligia L Corrales-García,Ximena Rodriguez-Ruiz et al.
Guillermo de la Rosa et al.
The three-fingered toxin family and more precisely short-chain α-neurotoxins (also known as Type I α-neurotoxins) are crucial in defining the elapid envenomation process, but paradoxically, they are barely neutralized by current elapid sn...
L-Cysteine in vitro can restore cellular glutathione and inhibits the expression of cell adhesion molecules in G6PD-deficient monocytes [0.03%]
L-半胱氨酸体外可恢复G6PD缺陷单核细胞的谷胱甘肽并抑制细胞粘附分子的表达
Rajesh Parsanathan,Sushil K Jain
Rajesh Parsanathan
L-Cysteine is a precursor of glutathione (GSH), a potent physiological antioxidant. Excess glucose-6-phosphate dehydrogenase (G6PD) deficiency in African Americans and low levels of L-cysteine diet in Hispanics can contributes to GSH defici...
Polymorphism at donkey β-lactoglobulin II locus: identification and characterization of a new genetic variant with a very low expression [0.03%]
驴β-乳球蛋白II基因座多态性的鉴定及一个新的低表达等位基因的特征分析
Andrea Criscione,Vincenzo Cunsolo,Serena Tumino et al.
Andrea Criscione et al.
In the last years, donkey milk had evidenced a renewed interest as a potential functional food and a breast milk substitute. In this light, the study of the protein composition assumes an important role. In particular, β-lactoglobulin (β-...
Taurine supplementation induces long-term beneficial effects on glucose homeostasis in ob/ob mice [0.03%]
牛磺酸补充对ob/ob小鼠长期血糖稳定的益处
Patricia Cristine Borck,Jean Franciesco Vettorazzi,Renato Chaves Souto Branco et al.
Patricia Cristine Borck et al.
The sulfur-containing amino acid, taurine (Tau), regulates glucose and lipid homeostasis under normal, pre- and diabetic conditions. Here, we aimed to verify whether Tau supplementation exerts its beneficial effects against obesity, hypergl...
The effects of taurine on repeat sprint cycling after low or high cadence exhaustive exercise in females [0.03%]
taurine对低或高踏频力竭运动后女子重复全力骑行的影响
Mark Waldron,Francesca Knight,Jamie Tallent et al.
Mark Waldron et al.
This study investigated the effects of taurine on repeated sprint exercise, performed after fixed incremental ramp exercise to exhaustion at isokinetic high (90 r/min) or low (50 r/min) cadences. In a double-blind, repeated measures design,...
Randomized Controlled Trial
Amino acids. 2018 Jun;50(6):663-669. DOI:10.1007/s00726-018-2554-2 2018