Exploring claudin proteins: from sequence motifs to their impact on tight junction-mediated signaling pathways [0.03%]
Claudin蛋白的研究：从序列基元到其对紧密连接介导的信号通路的影响
Lingling Bao,Siqi Yang,Wenhua Zhao et al.
Lingling Bao et al.
Claudin (CLDN) proteins are extensively studied due to their critical role in maintaining tissue barriers and cell polarity. However, significant gaps remain in understanding the functional mechanisms of their sequence motifs and the molecu...
Protolytic properties and biological activity of spinorphin and its butyric acid derivatives in aqueous solution [0.03%]
spinorphin及其丁酸衍生物的水溶液中的质子解离性质及生物学活性
Marek Pająk,Elżbieta Kamysz,Marcin Banach et al.
Marek Pająk et al.
The present work describes the protolytic properties and in vitro biological activity of spinorphin (Leu-Val-Val-Tyr-Pro-Trp-Thr) and three spinorphin derivatives containing butyric acid residue: Butyryl-Lys-Lys-Leu-Leu-Val-Tyr-Pro-Trp-Thr,...
Associations between XRCC1-Arg399Gln polymorphism and the risk of prostate cancer: an updated meta-analysis [0.03%]
XRCC1-Arg399Gln多态性与前列腺癌风险的关联：一项更新的meta分析
Jiang Deng,Lihua Xu,Jun Zhou et al.
Jiang Deng et al.
The X-ray repair cross-complementary group 1 (XRCC1) gene 399 codon polymorphism may alter the structure of DNA repair enzymes to regulate DNA repair capacity. Impaired DNA repair ability can lead to the development of cancers such as prost...
Meta-Analysis
Amino acids. 2025 Sep 18;57(1):46. DOI:10.1007/s00726-025-03475-0 2025
Rational designing and synthesizing an antimicrobial peptide from bovine milk casein and evaluating its biological properties [0.03%]
基于牛乳酪蛋白的抗菌肽理性设计、合成及生物学性质评价
Seyed Reza Pourhosseini,Bahman Akbari,Elahe Ghods et al.
Seyed Reza Pourhosseini et al.
The overuse of antibiotics has led to a growing crisis-antimicrobial resistance, making it harder to treat infections and pushing scientists to find new solutions. Among the most promising alternatives are bioactive peptides, especially ant...
Metabolic alterations in diabetic patients: aqueous humor profiling for biomarker discovery [0.03%]
糖尿病患者代谢改变的房水蛋白质组学研究及生物标志物发现
Arturs Zemitis,Lelde Svjascenkova,Sandra Bleidele et al.
Arturs Zemitis et al.
Diabetic retinopathy, a leading cause of vision loss in working-age populations, is a severe complication of diabetes mellitus. Metabolomics, a key approach in systems biology, offers insights into the complex pathophysiology of diabetes by...
Exploring the therapeutic potential of L-arginine in chronic anal fissure management: a comprehensive review [0.03%]
L-精氨酸治疗慢性肛裂的潜力：综述
Nogol Motamed-Gorji,Mohsen Masoodi,Masoumeh Khalighi Sikaroudi et al.
Nogol Motamed-Gorji et al.
Anal fissure causes pain and bleeding during or after bowel movements, significantly impacting individuals' quality of life. Current treatments aim to interrupt this cycle but have associated risks and limitations. The emergence of arginine...
IGF2BP1-mediated methylation of ABCA1 facilitates tumor progression by affecting cholesterol metabolism in lung adenocarcinoma [0.03%]
IGF2BP1介导的ABCA1甲基化通过影响胆固醇代谢促进肺腺癌进展
Shaohua Xu,Kai Liu,Zhao Chen et al.
Shaohua Xu et al.
ABCA1 is a key protein in maintaining cholesterol homeostasis, and its abnormal expression is associated with the progression of many cancers. Nonetheless, the specific molecular mechanisms by which ABCA1 facilitates the development of LUAD...
Insight into the structure of antitubercular Callyaerins: conformational studies and synthesis of a unique dehydroamino acid, β-aminodehydroalanine [0.03%]
抗结核药物Callyaerins的结构研究：构象分析及独特脱氢氨基酸β-氨基脱氢丙氨酸的合成
Karolina Banaś,Paweł Lenartowicz,Dawid Siodłak
Karolina Banaś
β-Aminodehydroalanine, ΔAla(β-NH), (2,3-diaminoprop-2-enoic acid), is a unique dehydroamino acid and a central component of Callyaerins A-M and Callynormine A. The presence of this unusual structural element containing an enamine functio...
Post-translational modifications of ezrin: a crucial regulator for diseases [0.03%]
易位蛋白的翻译后修饰：疾病的关键调节因子
Yi-Chen Li,Hong-Kai Yuan,Lei-Miao Yin
Yi-Chen Li
Ezrin is a crucial structural protein that connects the plasma membrane to the actin cytoskeleton to maintain cell shape, adhesion, and motility. Post-translational modifications (PTMs) play a key role in the regulation of various biologica...
The effect of L-Arg supplementation on L-Arg/NO metabolic and AMPK/ACC-1 signalling pathways in adipose cells (3T3 L1) [0.03%]
L-精氨酸补充对脂肪细胞(L-精氨酸/一氧化氮代谢和AMPK/ACC-1信号途径)的影响
Saranya Prashath
Saranya Prashath
L-arginine (L-Arg) is metabolised in the cell to generate nitric oxide (NO) and citrulline via nitric oxide synthase (NOS). NO is an important cellular signalling molecule that regulates lipid and glucose metabolism. The biological availabi...