Efficient acrylamide adduct formation suggests dual applications of ReAIV L-asparaginase [0.03%]
高效的丙烯酰胺加合物形成表明ReAIV天冬酰胺酶的双重应用
Joanna Sliwiak,Marta Grzechowiak,Paulina Worsztynowicz et al.
Joanna Sliwiak et al.
Isothermal titration calorimetry (ITC) studies of the enzyme kinetics and substrate specificity of Rhizobium etli Class 3 L-asparaginases, ReAIV (constitutive) and ReAV (inducible), showed that despite highly conserved catalytic site, the t...
Analysis of total and free amino acid compositions of fishery byproducts from three commonly consumed fish species in South Korea [0.03%]
三种韩国常见食用鱼类加工副产物的总氨基酸和游离氨基酸组成分析
Jeonghoon Han,Ji-Yeon Hyeon,Yeon-Ju Lee et al.
Jeonghoon Han et al.
Largehead hairtail (Trichiurus japonicus), kwangtung skate (Dipturus kwangtungensis), and mottled skate (Raja pulchra) are the most popular aquatic products in Korea. In the present study, total and free amino acid analyses were performed t...
PCLPred: identifying plant chloride transport-related proteins using reduced amino acid alphabets and N-peptide composition [0.03%]
基于降维氨基酸字母和N-肽组成的植物氯离子运输相关蛋白识别方法PCLPred
Ge Bai,Lijia Liu,Hui Zhang et al.
Ge Bai et al.
Chloride transport-related proteins play critical roles in coordinating ion cycling, maintaining cellular homeostasis, and enabling plants to dynamically adapt to environmental changes, particularly under salt stress conditions. Given the r...
Targeting the amino acid metabolic axis: the Achilles' heel of tumor cells [0.03%]
靶向氨基酸代谢轴：肿瘤细胞的阿喀琉斯之踵
Zheyu Hu,Yiwei Wang,Qian Ma
Zheyu Hu
Cancer is characterized by profound reprogramming of its metabolic programs, with the unending demand for exogenous amino acids by tumor cells serving as a hallmark manifestation. While this high dependency supports rapid proliferation, it ...
Revisiting the antizyme 1 - ODC interaction reveals low-nanomolar affinity [0.03%]
重新研究的抗酶素1-鸟氨酸脱羧酶相互作用显示低纳摩尔亲和力
Grzegorz P Bereta,Elżbieta Wątor-Wilk,Paweł Kochanowski et al.
Grzegorz P Bereta et al.
Ornithine decarboxylase (ODC) catalyzes the rate-limiting step in polyamine biosynthesis and is one of the shortest-lived mammalian proteins. Its activity and proteasomal degradation are controlled by antizyme (AZ), which disrupts the activ...
Maternal dietary citrulline supplementation increases fetal growth and programs pancreatic development in the lambs [0.03%]
精氨酸补充增加母体饮食中瓜氨酸的含量可促进胎儿生长并编程羔羊的胰腺发育
Alissa B Herring,Kyle S Herron,London G Lemcke et al.
Alissa B Herring et al.
Intrauterine growth restriction (IUGR), caused by maternal undernutrition, impairs fetal growth and increases the risk for postnatal metabolic dysfunction. L-arginine can mitigate these effects; however, its use in sheep is limited by rumin...
Reprogramming of nitrogen metabolism in tumors: mechanisms and therapeutic implications [0.03%]
肿瘤中的氮代谢重编程：机制和治疗意义
Jiaqi Fang,Jing Ling,Xinyue Liu et al.
Jiaqi Fang et al.
Nitrogen metabolism plays a key role in maintaining normal physiological functions of the organism and cell proliferation and differentiation. Nitrogen metabolism in normal human body maintains a dynamic balance to meet the body's demand fo...
Spider peptides from Brachypelma smithi with slightly different amino acids at their C-terminal loops exert different insecticidal activities [0.03%]
粗纹管角颈扭棱蜘蛛C末端环区氨基酸稍有不同的蜘蛛毒素多肽其杀虫活性不同
Herlinda Clement,Lilu Corrales-García,Víctor Carpanta et al.
Herlinda Clement et al.
The insecticidal molecules of spiders persistently evolve to ensure rapid paralysis of their prey, and the best molecules are transmitted to their progeny. Here, we cloned two insecticidal peptides, Bs2 and Bs3, from the venom glands of the...
The remarkable legacy of the K6/ODC mouse: mechanisms of polyamine-promoted tumorigenesis revealed [0.03%]
K6/ODC小鼠的非凡遗产：揭示多胺促肿瘤发生的机制
Susan K Gilmour
Susan K Gilmour
Using the well-studied two-stage model of skin carcinogenesis, the first transgenic mouse with targeted expression of a polyamine metabolic enzyme was generated 30 years ago. Ornithine decarboxylase (ODC), a key regulating enzyme of polyami...
At the core of global bioenergy: polyamines and transglutaminases in chloroplasts [0.03%]
叶绿体聚胺和转谷氨酰胺酶位于全球生物能源的核心位置
Donatella Serafini-Fracassini,Stefano Del Duca
Donatella Serafini-Fracassini
Chloroplasts are the energy factories of photosynthetic life. The energy and the plant biomass of the planet depend on the activity of chloroplasts. Their efficiency results from a delicate balance between membrane organization, metabolic r...