Amino acid metabolism-related model for prognosis and immunity in gastric cancer [0.03%]
胃癌预后及免疫的氨基酸代谢相关模型
Huan Zhang,Wei Ye,Lingzhi Zeng et al.
Huan Zhang et al.
Amino acid metabolic (AAM) reprogramming is a key characteristic of gastric cancer (GC) cells metabolic remodeling, which regulates cell growth, survival, immune cell activation and function to affect tumor immune escape. This study aims to...
Branched-chain polyamines: evolutionary adaptation and biotechnological potential [0.03%]
支链多胺：进化适应与生物技术潜力
Shinsuke Fujiwara,Wakao Fukuda
Shinsuke Fujiwara
Branched-chain polyamines (BCPAs), exemplified by N⁴-bis(aminopropyl)spermidine, are distinctive polycations that occur predominantly in thermophilic bacteria and euryarchaeal archaea. Their dedicated aminopropyltransferase, BpsA (EC 2.5.1...
Tryptophan metabolism reprogramming regulates Th1/Th2 immune balance and inhibits mast cell activation [0.03%]
色氨酸代谢重编程调控Th1/Th2免疫平衡及抑制mast细胞活化
Dongsheng Huang,Dongxuan Huang,Lianhui Su et al.
Dongsheng Huang et al.
Asthma is characterized by chronic airway inflammation and an imbalanced Th1/Th2 response. Although tryptophan metabolism has been implicated in immune regulation, its direct influence on Th1/Th2 differentiation and mast-cell activation rem...
Probiotic and microbial modulation of polyamine production: an emerging avenue for neuroprotection in neurodegenerative disorders [0.03%]
益生菌和微生物对多胺产生的调节作用：在神经退行性疾病中保护神经细胞的新途径
Tushar Adhikari,Prerona Saha
Tushar Adhikari
Neurodegenerative disorders are an Critical worldwide issue, characterized by progressive neuronal loss and cognitive decline with limited effective therapies. A central problem in these conditions is chronic neuroinflammation, oxidative st...
Association of homoarginine with arginine and disease severity in COVID-19 patients: comment [0.03%]
论同源精氨酸与精氨酸的关联及同源精氨酸在新冠肺炎患者中的病情严重程度：评述
Hinpetch Daungsupawong,Viroj Wiwanitkit
Hinpetch Daungsupawong
Using animal models to decipher the role of polyamines in the pancreas and β Cell [0.03%]
利用动物模型解析多胺在胰腺和β细胞中的作用
Armando A Puente,Lyra Kinderlerer,Luna J Castillo et al.
Armando A Puente et al.
Pancreatic islet β cells are insulin-secreting cells that are responsible for sensing blood glucose levels and maintaining normoglycemia. Polyamines are vital to supporting the transcriptional and translational demands placed on secretory ...
Solid-state cultivation-specific agmatine production by Aspergillus oryzae: current understanding and perspectives [0.03%]
曲霉固态发酵特异性产生_agmatine_的机制研究及展望
Naoki Akasaka,Daisuke Watanabe,Kiyoshi Yasukawa et al.
Naoki Akasaka et al.
Agmatine, a natural polyamine generated from arginine by arginine decarboxylase (ADC), has attracted increasing attention because of its pleiotropic beneficial effects on neuroprotection, lifestyle-related diseases, and gut-brain axis-media...
Izabela Zakrocka,Radosław Mlak,Natalia Moniczewska et al.
Izabela Zakrocka et al.
Hemodialysis (HD) and hemodiafiltration (HDF) procedures have limited efficacy regarding removal of selected toxins. Tryptophan (Trp) metabolites formed through the kynurenine (KYN) pathway are known to contribute to kidney failure (KF) com...
Unveiling the anti-glycation properties of acetylsalicylic acid: targeted inhibition of albumin glycation [0.03%]
揭开乙酰水杨酸的抗糖基化特性：白蛋白糖基化的靶向抑制
Rashmi Tupe,Ankita Durge,Ashwini Jagdale
Rashmi Tupe
Glycation due to increased blood sugar levels aggravates diabetic complications. Glycation hampers the structural and functional integrity of human serum albumin (HSA). Acetylsalicylic acid (ASA)/aspirin exhibits anti-glycation properties. ...
Epithelial hypusination regulates Helicobacter pylori-induced gastric inflammation [0.03%]
胃上皮细胞假瓜氨酸化调控幽门螺旋杆菌诱导的胃部炎症反应
Alain P Gobert,Kara M McNamara,Caroline V Hawkins et al.
Alain P Gobert et al.
Hypusine is a unique amino acid synthesized on the eukaryotic initiation factor 5 A (EIF5A) from the polyamine spermidine by deoxyhypusine synthase (DHPS). Hypusination of EIF5A plays a key role in translation. Here, we examined the contrib...