Development and validation of a predictive model for pleural effusion control following talc pleurodesis in malignant pleural effusion [0.03%]
恶性胸腔积液滑石粉胸膜固定术疗效预测模型的建立与验证
Shunya Hanawa,Masaru Ejima,Mari Sugawara et al.
Shunya Hanawa et al.
Background: Talc slurry pleurodesis is widely used for malignant pleural effusion (MPE); however, its success rate ranges from 50 to 75%, and reliable predictors are lacking. This study aimed to identify predictors of ple...
A paradigm shift in genetic predisposition to colorectal cancer: the impact of germline multigene panel testing on diagnosis and management [0.03%]
遗传倾向与结直肠癌的范式转变：基因检测对诊断和治疗的影响
Kenji Fujiyoshi,Tomoya Sudo,Satoshi Shimamura et al.
Kenji Fujiyoshi et al.
Hereditary colorectal cancer (HCRC), arising from pathogenic germline variants, accounts for 5-10% of all CRCs. The widespread clinical adoption of next-generation sequencing (NGS) and multigene panel testing (MGPT) has fundamentally transf...
Artificial intelligence for diagnosis and triage in oral cancer: a clinician‑centered narrative review [0.03%]
面向临床医生的口腔癌诊断与分诊的人工智能：综述文章
Shin-Ichiro Hiraoka,Kohei Kawamura,Ryo Akiyama et al.
Shin-Ichiro Hiraoka et al.
Background: Early diagnosis of oral squamous cell carcinoma (OSCC) remains challenging, with survival largely stage-dependent at presentation. Artificial intelligence (AI) promises to enhance detection and clinical decisi...
Comprehensive circulating tumor DNA mutation profiling via CAPP-Seq liquid biopsy for cervical cancer [0.03%]
宫颈癌的CAPP-Seq液体活检全面循环肿瘤DNA突变检测Profiler结果分析
Naoyuki Iwahashi,Tomoko Noguchi,Kazuko Sakai et al.
Naoyuki Iwahashi et al.
Background: Liquid biopsy using circulating tumor DNA (ctDNA) is a minimally invasive approach for detecting tumor-associated genomic alterations. Although ctDNA analysis has been widely explored in solid tumors, its appl...
Interleukin-1 receptor type 1 in pancreatic cancer progression and metastasis: a review [0.03%]
胰腺癌进展和转移中 interleukin-1 受体类型 1 的作用：综述
Kenta Saito,Yoichi Matsuo,Yuki Denda et al.
Kenta Saito et al.
Pancreatic ductal adenocarcinoma (PDAC) is a global lethal malignancy, with increasing incidence and dismal survival rates. Inflammation plays a central role in shaping PDAC biology, and interleukin-1 receptor type 1 (IL-1R1) is a key media...
Comparative genomic landscape of primary and metastatic bladder urothelial carcinoma in a large-scale cohort [0.03%]
大样本队列中初发和转移性膀胱尿路上皮癌的基因组景观比较
Akira Ohtsu,Yusuke Otani,Seiji Arai et al.
Akira Ohtsu et al.
Background: Metastatic bladder urothelial carcinoma has poor survival, and large comparative genomic studies using uniform targeted sequencing of paired primary and metastatic lesions remain limited. We compared gene- and...
Validation of the 9th Edition of the UICC TNM classification and the prognostic impact of nodal spread in salivary gland cancer [0.03%]
国际抗癌联盟TNM分类（第9版）的验证及淋巴结转移在涎腺癌预后中的影响
Satoshi Kano,Takayoshi Suzuki,Nayuta Tsushima et al.
Satoshi Kano et al.
Background: The 9th edition of the UICC TNM classification redefined N categories and clinical stages for salivary gland cancer (SGC). We validated the prognostic utility of this redefinition and evaluated the impact of a...
Clinical development of molecular residual disease (MRD) and multi-cancer early detection (MCED) using liquid biopsy multiomics with artificial intelligence (AI) [0.03%]
基于液体活检多组学与人工智能（AI）的分子残留病(MRD)和多癌症早期检测(MCED)的临床开发
Taro Shibuki,Riu Yamashita,Tadayoshi Hashimoto et al.
Taro Shibuki et al.
Background: Early detection of cancer and precise recurrence monitoring remain major unmet needs in oncology. Conventional screening is limited to a few cancer types, leaving nearly half of cancers without established pro...
Beyond tumor mutational burden: a framework for immune-checkpoint blockade responsiveness in gastrointestinal cancers [0.03%]
肿瘤突变负荷以外的作用：胃肠癌免疫检查点阻断反应性框架
Kimihiro Yamashita,Mitsugu Fujita,Masafumi Saito et al.
Kimihiro Yamashita et al.
Immune-checkpoint blockade (ICB) elicits profound and durable responses in mismatch repair-deficient (dMMR) or microsatellite instability-high (MSI-H) gastrointestinal (GI) cancers, yet most microsatellite-stable (MSS) cancers derive minima...
Comprehensive assessment of postoperative quality of life and risk factors after robot-assisted radical prostatectomy using the EPIC questionnaire [0.03%]
经尿道机器人辅助根治性前列腺切除术后生活质量的综合评价及风险因素分析(EPIC问卷)
Toru Sakatani,Kimihiko Masui,Toshihiro Magaribuchi et al.
Toru Sakatani et al.
Background: Robot-assisted radical prostatectomy (RARP) is a standard treatment for localized prostate cancer. This procedure provides favorable oncologic outcomes but poses functional challenges, particularly urinary inc...