Timing-dependent skin toxicity phenotypes during enfortumab vedotin plus pembrolizumab therapy for advanced urothelial carcinoma [0.03%]
恩fortumab Vedotin联合派姆单抗治疗晚期尿路上皮癌的时间依赖性皮肤毒性反应表型
Mamoru Hashimoto,Lan Inoki,Yutaka Yamamoto et al.
Mamoru Hashimoto et al.
Background: Enfortumab vedotin plus pembrolizumab (EV/Pem) has improved the survival of patients with advanced urothelial carcinoma; however, many patients suffer treatment-related adverse events, particularly skin toxici...
Workforce and institutional factors associated with comprehensive genomic profiling utilization in gynecologic oncology: a nationwide questionnaire survey in Japan [0.03%]
日本全国妇科肿瘤学问卷调查中与全面基因组谱分析利用相关的 workforce 和机构因素
Tamotsu Sudo,Kenta Masuda,Katsutoshi Oda et al.
Tamotsu Sudo et al.
Background: Comprehensive genomic profiling (CGP) has been widely introduced into precision oncology; however, its real-world implementation in gynecologic oncology remains unclear. This study evaluated nationwide CGP uti...
Germline pathogenic variants in Japanese adolescents and young adults with advanced solid tumors: a nationwide tumor-normal paired sequencing study [0.03%]
日本青少年和年轻人晚期实体瘤种系致病变异的全国性肿瘤-正常组织配对测序研究
Kota Ishioka,Naomi Hayashi,Naoki Miyazaki et al.
Kota Ishioka et al.
Background: Adolescents and young adults (AYA) aged 15 to 39 years with cancer have a higher prevalence of germline pathogenic variants than older patients. This study characterized the prevalence and distribution of germ...
AI-integrated multi-omics platform to revolutionize anti-metastatic therapy development through circulating tumor cell profiling: SCRUM-MONSTAR-CTC [0.03%]
一种通过循环肿瘤细胞谱系进行抗转移治疗开发的革命性多组学平台：SCRUM-MONSTAR-CTC项目
Tadayoshi Hashimoto,Taro Shibuki,Takao Fujisawa et al.
Tadayoshi Hashimoto et al.
Background: Metastatic disease remains the leading cause of cancer-related death, yet most precision oncology strategies still emphasize profiling primary tumors and tracking cell-free tumor DNA (ctDNA). Although ctDNA ha...
Observed ALK fusion/rearrangement frequency across comprehensive genomic profiling platforms in Japanese routine oncology practice [0.03%]
日本常规肿瘤学实践中的全面基因组分析平台所观察到的ALK融合/重排频率
Shinya Kajiura,Naohiko Nakamura,Ryuji Hayashi
Shinya Kajiura
Background: Clinically relevant ALK alterations are identified across routine comprehensive genomic profiling (CGP), but their observed frequency may vary according to testing context. Because ALK-directed treatment is pr...
Forecasting colorectal cancer screening in Japan: regional and sex disparities threaten national targets [0.03%]
日本结直肠癌筛查预测：地区和性别差异威胁国家目标
Hasan Jamil,Aminu Kende Abubakar,Takao Suzuki et al.
Hasan Jamil et al.
Objective: To forecast prefecture-level progress toward Japan's 60% colorectal cancer (CRC) screening target by 2028 and quantify regional and sex-based disparities. ...
Guideline-concordant treatment and clinical outcomes in older patients with endometrial cancer in Japan: a retrospective single-institution study [0.03%]
日本老年子宫内膜癌患者符合指南治疗与临床结局的单中心回顾性研究
Kanako Kasuya,Naoko Komura,Satoshi Nakagawa et al.
Kanako Kasuya et al.
Background: To evaluate achievement of Japanese guideline-concordant treatment (J-GCT) and examine its association with clinical outcomes among older patients with endometrial cancer. ...
Cost-effectiveness analysis of chemoradiotherapy compared to surgery in patients with stage I esophageal squamous cell carcinoma in Japan [0.03%]
日本一期食管鳞癌患者接受化学放射治疗与手术治疗的成本效益分析
Takuro Ariga,Kensuke Moriwaki,Kousuke Morimoto et al.
Takuro Ariga et al.
Purpose: We performed a model-based cost-effectiveness analysis of the use of surgical treatment (ST) versus chemoradiotherapy (CRT) for stage I esophageal cancer in Japan. ...
Efficacy of anti-GD2 antibody immunotherapy with filgrastim and teceleukin versus standard treatment with sargramostim, aldesleukin and isotretinoin in children with high-risk neuroblastoma [0.03%]
抗GD2抗体免疫疗法联合非格司亭和泰赛利欣与标准治疗沙格司亭、奥德司妥林和异维甲酸治疗高危神经母细胞瘤儿童的疗效比较研究
Chika Nitani,Junichi Hara,Hiroshi Kawamoto et al.
Chika Nitani et al.
Background: Granulocyte-macrophage colony-stimulating factor (GM-CSF), aldesleukin and isotretinoin are unavailable in Japan, necessitating alternative cytokines for dinutuximab immunotherapy. We compared the efficacy of ...
Identification and functional validation of lipid droplet-associated prognostic biomarkers in breast cancer via integrative multi-omics and machine learning approaches [0.03%]
通过整合多组学和机器学习方法识别并功能验证乳腺癌中的脂滴相关预后生物标志物
Jia Yao,Zhen Liu,Jing Zhang et al.
Jia Yao et al.
Background: Lipid droplet (LD)-associated metabolic reprogramming plays a critical role in breast cancer progression and immune modulation, yet robust prognostic biomarkers and their functional mechanisms remain incomplet...