The novel high-frequency variant of TRPV3 p.A628T in East Asians showing faster sensitization in response to chemical agonists [0.03%]
东亚人新型高频TRPV3变异体p.A628T对化学激动剂快速敏化响应显示更高的反应性
Seong Woo Choi,Si Won Choi,Jeesoo Chae et al.
Seong Woo Choi et al.
TRPV3, a member of the thermosensitive Ca2+-permeable TRPV channel subfamily expressed in skin and sensory nerves, is also activated by chemical agonists such as 2-aminoethyl diphenylborinate (2-APB). Repetitive stimuli induce sensitization...
Alexei Verkhratsky,Jose Julio Rodrigues,Augustas Pivoriunas et al.
Alexei Verkhratsky et al.
Astrocytes, a class of morphologically and functionally diverse primary homeostatic neuroglia, are key keepers of neural tissue homeostasis and fundamental contributors to brain defence in pathological contexts. Failure of astroglial suppor...
TREK-1 protects the heart against ischemia-reperfusion-induced injury and from adverse remodeling after myocardial infarction [0.03%]
TREK-1保护心脏免受缺血再灌注损伤以及心肌梗死后的心室重构的影响
Samuel Kamatham,Christopher M Waters,Andreas Schwingshackl et al.
Samuel Kamatham et al.
The TWIK-related K+ channel (TREK-1) is a two-pore-domain potassium channel that produces background leaky potassium currents. TREK-1 has a protective role against ischemia-induced neuronal damage. TREK-1 is also expressed in the heart, but...
Gain-of-function mutations of the V2 vasopressin receptor in nephrogenic syndrome of inappropriate antidiuresis (NSIAD): a cell-based assay to assess constitutive water reabsorption [0.03%]
血管加压素V2受体的获得性功能突变在不适当抗利尿激素引起的肾性综合征（NSIAD）中的作用：基于细胞的测定法评估自发性水分吸收的功能得性突变体血管加压素V2受体在不适当抗利尿激素引起的肾性综合征（NSIAD）中的作用：基于细胞的测定法评估自发性水分吸收
Marianna Ranieri,Grazia Tamma,Tommaso Pellegrino et al.
Marianna Ranieri et al.
Nephrogenic syndrome of inappropriate antidiuresis (NSIAD) is a recently identified chromosome X-linked disease associated with gain-of-function mutations of the V2 vasopressin receptor (V2R), a G-protein-coupled receptor. It is characteriz...
Unconventional eNOS in pulmonary artery smooth muscles: why should it be there? [0.03%]
肺动脉平滑肌中的非典型eNOS：它为何存在那儿？
Tong Mook Kang
Tong Mook Kang
Fast relaxation and desensitization of angiotensin II contraction in the pulmonary artery via AT1R and Akt-mediated phosphorylation of muscular eNOS [0.03%]
血管紧张素II通过AT1受体和Akt介导的肌肉内一氧化氮合酶磷酸化在肺动脉中的快速缓解和脱敏作用
Hae Jin Kim,Ji Hyun Jang,Yin Hua Zhang et al.
Hae Jin Kim et al.
Angiotensin II (AngII) triggers a transient contraction of pulmonary arteries (PAs) followed by protracted desensitization. Based on the unconventional eNOS expression in PA smooth muscle cells (PASMCs), we hypothesized that activation of s...
Isoproterenol enhances force production in mouse glycolytic and oxidative muscle via separate mechanisms [0.03%]
异丙肾上腺素通过不同的机制增强小鼠糖酵解型和氧化型肌肉的收缩力
Sarah J Blackwood,Abram Katz
Sarah J Blackwood
Fight or flight is a biologic phenomenon that involves activation of β-adrenoceptors in skeletal muscle. However, how force generation is enhanced through adrenergic activation in different muscle types is not fully understood. We studied ...
Hypothalamic TRPV4 channels participate in the medial preoptic activation of warmth-defence responses in Wistar male rats [0.03%]
纹状前核TRPV4通道参与Wistar大鼠温暖防御反应机制
Carolina da Silveira Scarpellini,Caroline Cristina-Silva,Vivian Biancardi et al.
Carolina da Silveira Scarpellini et al.
Recently, we have described, in non-genetically modified rats, that peripheral transient receptor potential vanilloid-4 (TRPV4) channels are activated and trigger warmth-defence responses at ambient temperatures of 26-30 °C. Evidence point...
AT2 and MAS (but not AT1) angiotensinergic receptors in the medial amygdaloid nucleus modulate the baroreflex activity in rats [0.03%]
大鼠外侧杏仁核中的AT2和MAS(但不是AT1)血管紧张素受体可调节血压反应区的交感神经活动
Willian Costa-Ferreira,Lucas Gomes-de-Souza,Carlos C Crestani
Willian Costa-Ferreira
The medial amygdaloid nucleus (MeA) is a limbic structure that has been demonstrated to be part of the central circuitry regulating baroreflex function. However, the local neurochemical mechanisms involved in baroreflex control by this fore...
AT2 and MAS (but not AT1) angiotensinergic receptors in the medial amygdaloid nucleus modulate the baroreflex activity in rats [0.03%]
大鼠中央杏仁核的AT2和MAS（而非AT1）肾素-血管紧张素受体调节血压反射活动
Willian Costa-Ferreira,Lucas Gomes-de-Souza,Carlos C Crestani
Willian Costa-Ferreira
The medial amygdaloid nucleus (MeA) is a limbic structure that has been demonstrated to be part of the central circuitry regulating baroreflex function. However, the local neurochemical mechanisms involved in baroreflex control by this fore...