The bile acid-sensive ion channel (BASIC) is expressed in pancreatic α-cells and involved in glucagon secretion [0.03%]
胆酸敏感离子通道(BASIC)在胰岛α细胞中的表达及其参与胰高血糖素分泌的作用
Jingyu Yang,Stefan Gründer,Dominik Wiemuth
Jingyu Yang
Pancreatic α-cells play a key role in glucose homeostasis through glucagon secretion. Here, we discover that the bile acid-sensitive ion channel (BASIC), a Na+ channel of the DEG/ENaC family, has a hitherto unrecognized role in α-cell fun...
Sex-dependent and compartment-specific macrophage accumulation associates with glomerular injury in BTBR ob/ob mice [0.03%]
性激素依赖的和区室特异性巨噬细胞积聚与BTBR肥胖小鼠肾小球损伤相关
Mariana Charleaux de Ponte,Victoria Mel Dussan Angulo,Leticia Barreto da Silva et al.
Mariana Charleaux de Ponte et al.
Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by chronic hyperglycemia and represents a growing global health burden. One of its major complications is diabetic kidney disease (DKD), a progressive condition character...
Early Posttransplant urine ammonium-pH index levels and graft outcomes in kidney transplant recipients [0.03%]
肾移植受者早期尿铵-酸碱度指数与移植物预后之间的关系
Marie B Nielsen,Nicoline V Krogstrup,Mads V Sørensen et al.
Marie B Nielsen et al.
Introduction: Functional assessment is essential to quantify kidney graft quality early after kidney transplantation. Kidney transplantation is inherently associated with ischemia-reperfusion-injury, a noxious insult for ...
Towards an integrative structural model of the fishnet slit diaphragm: Understanding its physiology through proteomics and structural insight [0.03%]
朝向鱼网裂膈整合结构模型：通过蛋白质组学和结构洞察理解其生理功能
Achilleas S Frangakis,Alexandra N Birtasu,Florian Grahammer
Achilleas S Frangakis
The kidney slit diaphragm (SD) connects the foot processes of glomerular podocytes, anatomically forming the outermost part of the three-layered glomerular filtration barrier. The SD is a large molecular polymer that, together with the foot...
Klotho revisited: tubular heterogeneity reshapes mineral metabolism, aging, and CKD [0.03%]
再访克洛索蛋白：管状细胞异质性重塑矿稳态、衰老和CKD
Ganesh Pathare
Ganesh Pathare
α-Klotho (hereafter Klotho) was discovered as an aging-suppressor protein whose function is intrinsically dependent on the kidney. Its shed ectodomain, soluble Klotho (sKlotho), is detectable in blood and urine. As an obligate co-receptor ...
Electrophysiological characterization of neuropeptide S-expressing neurons in the periLC: influence of the female estrous cycle on neuronal excitability in mice [0.03%]
关于周围红核神经肽S阳性神经元的电生理学特征以及小鼠发情周期对其兴奋性的影响
Nike Leah Laukamp,Kay Jüngling
Nike Leah Laukamp
Neuropeptide S (NPS) signaling is critically involved in arousal, sleep-wake regulation, fear and anxiety, and related forms of learning and memory, yet comparatively little is known about whether intrinsic properties of identified NPS neur...
Acid-sensing ion channels in the vasculature: emerging roles in systemic and pulmonary circulations [0.03%]
血管中的酸感应离子通道：全身循环和肺循环中的新兴作用
Nikki L Jernigan
Nikki L Jernigan
Acid-sensing ion channels (ASICs) are proton-gated members of the degenerin/epithelial sodium channel family that are emerging as multifaceted regulators of cardiovascular function. ASICs expressed in baroreceptor, cardiac, and skeletal mus...
DuBois-Reymond prize lecture 2024: Multi-neuron patch-clamp to uncover the neuronal and synaptic physiology in the human neocortex [0.03%]
杜邦-雷蒙奖讲座2024：多神经元膜片钳技术揭示人类新皮层的神经和突触生理学
Yangfan Peng,Franz Xaver Mittermaier
Yangfan Peng
The physiology of neurons and synapses determines how networks in the brain process information. While these properties are well described in rodents, they are less well established for the human brain. Increasing availability of surgically...
A conceptual review of intracellular pH as a regulator of the adenosine-L-arginine-nitric oxide (ALANO) axis in human fetoplacental endothelial dysfunction in gestational diabetes mellitus [0.03%]
妊娠糖尿病中胎盘内皮功能障碍的腺苷-L-精氨酸-一氧化氮轴的调节：一个关于胞内pH的概念性综述
Gonzalo Fuentes,Paola Valero,Marcelo Cornejo et al.
Gonzalo Fuentes et al.
This conceptual review provides a synthesising narrative of the interdependent regulation of intracellular pH (pHi), nitric oxide (NO), and adenosine-the pHi-NO-adenosine triad-in fetoplacental endothelial dysfunction associated with gestat...
Repeated aluminum ingestion alters human intestinal structure: focus on advanced 3D tissue models [0.03%]
重复摄入铝可改变人体肠道结构：重点是先进的三维组织模型
Giulia De Negri Atanasio,Lorenzo Dondero,Francesca Tardanico et al.
Giulia De Negri Atanasio et al.
Aluminum (Al³⁺) is a widespread environmental metal with potential effects on the intestinal epithelium. In this study, we evaluated the impact of dietary concentrations of aluminum on barrier integrity, histological organization, and gen...