Sex-sensitive and insensitive endocrine responses and infradian changes while trekking in the Himalayas [0.03%]
喜马拉雅远足期间的性敏感和非敏感内分泌反应及亚月周期变化
Danilo Bondi,Sofia Bonan,Simone Cantarelli et al.
Danilo Bondi et al.
Various studies have explored the effects of altitude hypoxia on hormonal changes. However, most research has been conducted on small samples and focused solely on male subjects. This project aimed to examine the effects of high-altitude tr...
Pathophysiology of homocysteine: insights into ion channel dysfunction [0.03%]
同型半胱氨酸的病理生理学：离子通道功能障碍的新见解
Nikola Chmúrčiaková,Robin N Stringer,Leoš Cmarko et al.
Nikola Chmúrčiaková et al.
Homocysteine is a non-proteinogenic amino acid formed during the metabolism of methionine to cysteine and plays a critical role in maintaining cellular homeostasis. Although multiple enzymatic pathways tightly regulate homocysteine levels, ...
Upregulation of T-type voltage-dependent Ca²⁺ channels in activated hepatic stellate cells promotes liver fibrosis in metabolic dysfunction-associated steatohepatitis [0.03%]
代谢功能障碍相关steatohepatitis肝星状细胞活化促进肝纤维化的新机制：T型电压门控钙通道的上调作用
Naoki Kawata,Rubii Kondo,Mizuki Hashizume et al.
Naoki Kawata et al.
Tanecia Mitchell,Vivek Verma,Abul Fajol et al.
Tanecia Mitchell et al.
The kidney is a major regulator of phosphate metabolism. The body can lower systemic phosphate levels by increasing renal phosphate excretion, and kidney injury results in elevated serum phosphate concentrations (hyperphosphatemia). Chronic...
Targeting hypertension through natural phenolics: The multifaceted role of cinnamic acid and its derivatives [0.03%]
天然酚类化合物抗高血压作用及机制研究——以咖啡酸及其衍生物为例
Samuel S P de Araujo,Brenda L B Dos Santos,Waldilleny R A de Moura et al.
Samuel S P de Araujo et al.
Hypertension is a serious global public health problem that significantly increases the risk of cardiovascular diseases. Its etiology involves inflammatory processes, oxidative stress, and imbalances in blood pressure (BP) regulatory system...
DNase I as a probe for unpolymerized actin: revisiting a classic tool for nuclear actin research [0.03%]
核内核膜下存在可溶的未聚合并与DNA结合的G-肌动蛋白分子簇：经典工具DNase I的新角色
Anika Göpel,Laura Bauer,Dörthe M Katschinski et al.
Anika Göpel et al.
Actin is a key component of the cytoskeleton and also plays diverse roles within the cell nucleus. While polymerized F-actin can be detected using a wide range of probes, reliable methods to identify unpolymerized (“G-”) actin in fixed ce...
Nitrergic neurotransmission within the lateral hypothalamus modulates cardiovascular responses to stress in rats [0.03%]
大鼠侧下丘脑内的硝基传递作用可调节应激的心血管反应
Gabriela A Silva,Lilian L Reis-Silva,Lucas Gomes-de-Souza et al.
Gabriela A Silva et al.
The lateral hypothalamus (LH) is a key brain region involved in integrating cardiovascular and autonomic components of the stress response, yet the local neurochemical mechanisms governing these functions remain poorly understood. This stud...
Low fruit and vegetable intake in children: a dietary stressor raising renal ammonium and adrenal cortisol secretion [0.03%]
儿童摄入水果和蔬菜不足：一种增加肾脏氨生成和肾上腺皮质醇分泌的饮食压力因素
Thomas Remer,Yifan Hua,Jonas Esche et al.
Thomas Remer et al.
Elimination of excess acid loads in metabolic acidosis requires stimulation of ammoniagenesis. Cortisol is critical to increase proximal tubular cells’ ammonia production. We aimed to specifically examine whether children’s low fruit and ...
PKC isoform-specific targeting of the phosphorylation site Serine191 in the GIRK4 subunit induces receptor-dependent modulation of GIRK channel activity [0.03%]
PKC异构体特异性靶向GIRK4亚单位的磷酸化位点丝氨酸191可诱导受体依赖性调节GIRK通道活性
Leonie Inderwiedenstraße,Marie-Cécile Kienitz
Leonie Inderwiedenstraße
G Protein activated inwardly rectifying K+ (GIRK) channels are inhibited during stimulation of Gq Protein-coupled receptors (GqPCRs) by depletion of phosphatidyl-4,5-bisphosphate (PIP2) and/or channel phosphorylation by proteinkinase C (PKC...
Charlotte Calvet,Philipp Villiger,Francesco Prisco et al.
Charlotte Calvet et al.
Carbon dioxide (CO2) is commonly used for rat euthanasia, but its potential negative side effects call for alternatives causing less distress while providing a fast and reliable loss of consciousness (LOC). Euthanasia with CO2 is currently ...