Pendrin inhibitor PDSinh-C01 reverses salt-sensitive hypertension and metabolic acidosis in the 5/6 nephrectomy rat model [0.03%]
PDSinh-C01逆转部分肾切除大鼠模型的盐敏感性高血压和代谢性酸中毒
Crissy F Rudolphi,Yoëlle Goos,Usha Musterd-Bhaggoe et al.
Crissy F Rudolphi et al.
Pharmacological inhibition of the chloride-bicarbonate exchanger pendrin with PDSinh-C01 potentiates the diuretic action of furosemide in healthy mice. Because pendrin contributes to acid-base regulation and blood pressure control, it may r...
NAPE-PLD: the healthy intersection of N-acylethanolamines and bile acids in physiology and diseases [0.03%]
NAPE-PLD：N-脂肪醇胺和胆汁酸在生理和疾病中的健康交集
Gianpiero Garau,Lucia Chico,Maico Polzella et al.
Gianpiero Garau et al.
Linking the distinctive structural and functional properties of lipids belonging to different signaling classes is a frontier of physiology. The present minireview focuses on the endocannabinoidome phospholipase NAPE-PLD, which has bile aci...
Long non-coding RNAs in exercise: the hidden regulators of adaptation [0.03%]
运动中的长链非编码RNA：适应性变化的幕后调节者
Qin Zhang,Zhouren Zhang,Cai Ren et al.
Qin Zhang et al.
Regular physical activity elicits coordinated molecular adaptations across skeletal muscle, the cardiovascular system, metabolic organs and the brain, underpinning improvements in performance and cardiometabolic health. While classical sign...
Jianyang Du,Qian Ge,Gyeongah Park
Jianyang Du
Acid-sensing ion channels (ASICs) are widely recognized as proton (H+)-gated cation channels that respond to extracellular acidification associated with pathological states such as ischemia, inflammation, and epilepsy. However, an emerging ...
TSLP impairs mucociliary transport by inhibiting JAK signaling in both central and peripheral airways [0.03%]
TSLP通过抑制JAK信号通路从而从中央和外周气道两方面损害黏液纤毛转运功能
Hatsumi Sugiyama,Tsutomu Tamada,Koji Murakami et al.
Hatsumi Sugiyama et al.
Mucociliary transport (MCT) is the dominant mechanical host defense system in human airways. Although the importance of the peripheral airway in the pathophysiology of bronchial asthma has recently attracted attention, the characteristics o...
The bile acid-sensive ion channel (BASIC) is expressed in pancreatic α-cells and involved in glucagon secretion [0.03%]
胆酸敏感离子通道(BASIC)在胰岛α细胞中的表达及其参与胰高血糖素分泌的作用
Jingyu Yang,Stefan Gründer,Dominik Wiemuth
Jingyu Yang
Pancreatic α-cells play a key role in glucose homeostasis through glucagon secretion. Here, we discover that the bile acid-sensitive ion channel (BASIC), a Na+ channel of the DEG/ENaC family, has a hitherto unrecognized role in α-cell fun...
Sex-dependent and compartment-specific macrophage accumulation associates with glomerular injury in BTBR ob/ob mice [0.03%]
性激素依赖的和区室特异性巨噬细胞积聚与BTBR肥胖小鼠肾小球损伤相关
Mariana Charleaux de Ponte,Victoria Mel Dussan Angulo,Leticia Barreto da Silva et al.
Mariana Charleaux de Ponte et al.
Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by chronic hyperglycemia and represents a growing global health burden. One of its major complications is diabetic kidney disease (DKD), a progressive condition character...
Early Posttransplant urine ammonium-pH index levels and graft outcomes in kidney transplant recipients [0.03%]
肾移植受者早期尿铵-酸碱度指数与移植物预后之间的关系
Marie B Nielsen,Nicoline V Krogstrup,Mads V Sørensen et al.
Marie B Nielsen et al.
Introduction: Functional assessment is essential to quantify kidney graft quality early after kidney transplantation. Kidney transplantation is inherently associated with ischemia-reperfusion-injury, a noxious insult for ...
Towards an integrative structural model of the fishnet slit diaphragm: Understanding its physiology through proteomics and structural insight [0.03%]
朝向鱼网裂膈整合结构模型：通过蛋白质组学和结构洞察理解其生理功能
Achilleas S Frangakis,Alexandra N Birtasu,Florian Grahammer
Achilleas S Frangakis
The kidney slit diaphragm (SD) connects the foot processes of glomerular podocytes, anatomically forming the outermost part of the three-layered glomerular filtration barrier. The SD is a large molecular polymer that, together with the foot...
Klotho revisited: tubular heterogeneity reshapes mineral metabolism, aging, and CKD [0.03%]
再访克洛索蛋白：管状细胞异质性重塑矿稳态、衰老和CKD
Ganesh Pathare
Ganesh Pathare
α-Klotho (hereafter Klotho) was discovered as an aging-suppressor protein whose function is intrinsically dependent on the kidney. Its shed ectodomain, soluble Klotho (sKlotho), is detectable in blood and urine. As an obligate co-receptor ...