Molecular determinants of HERG potassium channel blockade by domiphen bromide and benzethonium chloride [0.03%]
溴化多非フェンとベンゼチオン
Feng Tang,Zuoxian Lin,Rongqi Huang et al.
Feng Tang et al.
Domiphen bromide (DMP) and benzethonium chloride (BZT) are synthetic quaternary ammonium compounds widely used as disinfectants. Both agents are potent inhibitors of the human ether-à-go-go-related gene (HERG) potassium channel, a key cont...
Elabela alleviates ischemia/reperfusion-induced hepatic and remote organ injury by inhibiting oxidative stress in rats [0.03%]
Elabela通过抑制氧化应激缓解大鼠缺血再灌注所致的肝脏和远处器官损伤
Ayşegül Bahar Özocak,Leyla Semiha Şen,Leman Arslan Arıtürk et al.
Ayşegül Bahar Özocak et al.
Hepatic injury is one of the most critical problems in major liver surgeries, trauma, sepsis or shock. The novel Elabela (ELA) peptide was shown to exert protective effects against cardiac and renal injury. We hypothesized that ELA could al...
Jana Pourová,Patrícia Dias,Milan Pour et al.
Jana Pourová et al.
Tissue perfusion is acutely regulated by the changes in the vascular tone resulting in vasodilatation or vasoconstriction (there are also long-term changes in tissue perfusion, effectively accomplished by vascular remodeling). Even though v...
Oxygen dissociation curve inflection point during incremental exercise: a trigger for the Bohr effect [0.03%]
递增运动时氧解离曲线拐点：Bohr效应的触发因素
Holger H Burchert,William W Stringer,Ranjan K Dash
Holger H Burchert
We previously hypothesized that the inflection point of the oxygen dissociation curve (ODC) is linked to the gas exchange threshold (GET) during cardiopulmonary exercise testing. This hypothesis was supported by femoral venous blood gas dat...
Presynaptic maturation of inhibitory connections onto vasoactive intestinal polypeptide-expressing GABAergic interneurons in the mouse barrel field [0.03%]
小鼠 barrels 神经元中抑制性突触前成熟度的增加 sourceMapping：该句子的主要内容是关于“血管活性肠肽表达的GABA能中间神经元”的一个研究，具体来说就是这些中间神经元中的“抑制性连接”在“突触前成熟度”的变化。这里的“小鼠 barrels 神经元”可以理解为一种特定区域或类型的神经元，而不是字面意思的“桶状皮层”。因此，根据这个逻辑，将其翻译成中文如下：
“血管活性肠肽表达的GABA能中间神经元中抑制性突触前成熟度的小鼠 barrels 神经元研究”
但是为了更加通俗易懂，也可以简化为：
“小鼠血管活性肠肽 GABA 能中间神经元中的抑制性突触前成熟度变化”
Clara A Simacek,Sergei Kirischuk,Thomas Mittmann
Clara A Simacek
Vasoactive intestinal polypeptide-expressing inhibitory interneurons (VIP-INs) in the adult barrel cortex are crucial for mediating active whisking (AW) by disinhibiting pyramidal neurons. Past studies have investigated the development of V...
Acute activation of human epithelial sodium channel (ENaC) by serum and glucocorticoid inducible kinase 1 (SGK1) requires prior cleavage of the channel's γ-subunit at its proximal cleavage site [0.03%]
人血清和糖皮质激素诱导激酶1(SGKL)急性激活上皮钠通道(ENaC)需要预先在通道γ亚基的近端切割位点进行切割切除
Alexei Diakov,Florian Sure,Alexandr V Ilyaskin et al.
Alexei Diakov et al.
Serum and glucocorticoid inducible kinase 1 (SGK1) is a key regulator of the epithelial sodium channel (ENaC). In rat ENaC, the serine residue 621 (S621) in the channel's α-subunit is essential for acute channel activation by SGK1 in outsi...
Jana Pourová,Patrícia Dias,Milan Pour et al.
Jana Pourová et al.
Jana Pourová,Patrícia Dias,Milan Pour et al.
Jana Pourová et al.
Cardiovascular function depends on an adequate vascular tone facilitating appropriate blood flow to individual tissues according to their needs. The tone results from the interplay between vasodilatation and vasoconstriction. Its rapid and ...
Soft tissue calcifications in chronic kidney disease-beyond the vasculature [0.03%]
慢性肾脏病的软组织钙化-血管外机制
Abul Fajol,Christian Faul
Abul Fajol
Inappropriate mineralization of soft tissues, also called ectopic calcification, is a well-known pathology in chronic kidney disease (CKD) that is associated with increases in systemic phosphate levels. Vascular calcification is a major con...
Creatine monohydrate supplementation and NOX impact skeletal muscle microvascular blood flow: a pilot study [0.03%]
肌酸单水合物补充和NOX影响骨骼肌微血管血流：一项初步研究
Paul A Baker,Holly E Clarke,Cesar A Meza et al.
Paul A Baker et al.
Impaired blood flow and elevated reactive oxygen species (ROS) concentrations, generated primarily from NADPH oxidase (NOX), indicate risk for cardiovascular disease (CVD). Creatine monohydrate (CM) may reduce CVD risk by lowering ROS conce...