Nitrergic neurotransmission within the lateral hypothalamus modulates cardiovascular responses to stress in rats [0.03%]
大鼠侧下丘脑内的硝基传递作用可调节应激的心血管反应
Gabriela A Silva,Lilian L Reis-Silva,Lucas Gomes-de-Souza et al.
Gabriela A Silva et al.
The lateral hypothalamus (LH) is a key brain region involved in integrating cardiovascular and autonomic components of the stress response, yet the local neurochemical mechanisms governing these functions remain poorly understood. This stud...
Low fruit and vegetable intake in children: a dietary stressor raising renal ammonium and adrenal cortisol secretion [0.03%]
儿童摄入水果和蔬菜不足：一种增加肾脏氨生成和肾上腺皮质醇分泌的饮食压力因素
Thomas Remer,Yifan Hua,Jonas Esche et al.
Thomas Remer et al.
Elimination of excess acid loads in metabolic acidosis requires stimulation of ammoniagenesis. Cortisol is critical to increase proximal tubular cells’ ammonia production. We aimed to specifically examine whether children’s low fruit and ...
PKC isoform-specific targeting of the phosphorylation site Serine191 in the GIRK4 subunit induces receptor-dependent modulation of GIRK channel activity [0.03%]
PKC异构体特异性靶向GIRK4亚单位的磷酸化位点丝氨酸191可诱导受体依赖性调节GIRK通道活性
Leonie Inderwiedenstraße,Marie-Cécile Kienitz
Leonie Inderwiedenstraße
G Protein activated inwardly rectifying K+ (GIRK) channels are inhibited during stimulation of Gq Protein-coupled receptors (GqPCRs) by depletion of phosphatidyl-4,5-bisphosphate (PIP2) and/or channel phosphorylation by proteinkinase C (PKC...
Charlotte Calvet,Philipp Villiger,Francesco Prisco et al.
Charlotte Calvet et al.
Carbon dioxide (CO2) is commonly used for rat euthanasia, but its potential negative side effects call for alternatives causing less distress while providing a fast and reliable loss of consciousness (LOC). Euthanasia with CO2 is currently ...
Structural determinants of voltage sensitivity in hyperpolarization-activated ion channels and their persistence in the evolutionary scale [0.03%]
超极化激活离子通道电压敏感性的结构决定因素及其在进化尺度上的持久性
Karla G Alvarez-Villagómez,Daniel Balleza
Karla G Alvarez-Villagómez
HCN channels have a reverse electromechanical coupling mechanism, where hyperpolarized membrane potentials facilitate pore opening through an inward displacement of the S4 segment of the voltage-sensing domain (VSD). This voltage dependence...
Immature olfactory sensory neurons are intrinsically excitable and show maturation-dependent changes in voltage-gated Na+ and K+ currents [0.03%]
不成熟的嗅觉感觉神经元的内在兴奋性和电压门控钠离子和钾离子电流的成熟依赖性变化
Chiara Ricci,Cesar Adolfo Sánchez Triviño,Uday Rangaswamy et al.
Chiara Ricci et al.
Olfactory sensory neurons (OSNs) detect odorants and send electrical signals to glomeruli in the olfactory bulb. Unlike most neurons, OSNs are continuously regenerated throughout life and immature neurons contribute to odorant-evoked respon...
Preliminary evidence of extrarenal sodium storage in a large mammal: implications for comparative physiology and hypertension research : Running: Sodium storage in cattle [0.03%]
大型哺乳动物体外肾钠储存的初步证据：比较生理学和高血压研究的意义：跑步中的牛体内的钠储存
Andrew J Abraham,Ethan S Duvall,Callum Leese et al.
Andrew J Abraham et al.
Under conditions of dietary sodium (Na+) excess, the kidneys may fail to adequately excrete Na+, potentially compromising blood pressure homeostasis. Body tissues, such as skin, can offer sites of short-term extrarenal Na+ storage and previ...
Integrated effects of altered action potentials and calcium release on skeletal muscle force generation in transgenic Huntington's disease mice [0.03%]
转基因亨廷顿病小鼠骨骼肌动作电位和钙释放改变对肌肉收缩力的综合影响
Daniel R Miranda,Steven R A Burke,Pooneh Hajmirza Mohammadi Kamalabadi et al.
Daniel R Miranda et al.
Huntington’s disease (HD) is a movement disorder commonly recognized as being neurodegenerative. An increasing number of studies also show primary HD dysfunction in multiple tissues, consistent with the widespread expression of the mutated...
Active salt transport and countercurrent exchange as the basis of urine concentration: a proposal grounded on the microanatomy of the renal medulla [0.03%]
主动盐转运和逆流交换是尿液浓缩的基础：基于肾脏髓质微解剖结构的假说
Wilhelm Kriz,Brigitte Kaissling,Michel Le Hir
Wilhelm Kriz
The longitudinal arrangement of tubules and vessels in the renal medulla has in the early fifties of the last century given birth to the concept of countercurrent multiplication (CCM). Since then, enormous research has been expended, but a ...