A conceptual review of intracellular pH as a regulator of the adenosine-L-arginine-nitric oxide (ALANO) axis in human fetoplacental endothelial dysfunction in gestational diabetes mellitus [0.03%]
妊娠糖尿病中胎盘内皮功能障碍的腺苷-L-精氨酸-一氧化氮轴的调节：一个关于胞内pH的概念性综述
Gonzalo Fuentes,Paola Valero,Marcelo Cornejo et al.
Gonzalo Fuentes et al.
This conceptual review provides a synthesising narrative of the interdependent regulation of intracellular pH (pHi), nitric oxide (NO), and adenosine-the pHi-NO-adenosine triad-in fetoplacental endothelial dysfunction associated with gestat...
Repeated aluminum ingestion alters human intestinal structure: focus on advanced 3D tissue models [0.03%]
重复摄入铝可改变人体肠道结构：重点是先进的三维组织模型
Giulia De Negri Atanasio,Lorenzo Dondero,Francesca Tardanico et al.
Giulia De Negri Atanasio et al.
Aluminum (Al³⁺) is a widespread environmental metal with potential effects on the intestinal epithelium. In this study, we evaluated the impact of dietary concentrations of aluminum on barrier integrity, histological organization, and gen...
Expression of protein kinase A catalytic subunits in healthy and diseased mouse kidneys [0.03%]
蛋白激酶A催化亚基在健康和患病小鼠肾脏中的表达
Sally Fuchs,Michael Majer,Yuliang Ma et al.
Sally Fuchs et al.
Diabetic nephropathy (DN) is characterized by a decline in renal function resulting from hyperglycaemia and is often requiring dialysis or renal transplantation. Yet, the signalling events causing DN and the effective treatment options are ...
Localization of O₂‑sensing ADO‑RGS pathway components in mouse and human kidneys under normoxia, hypoxia and renal fibrosis [0.03%]
正常氧条件、低氧条件和肾纤维化条件下小鼠和人类肾脏中O2感受ADO-RGS通路组分的定位
Bkm Firmke,A-L Forst,C Daniel et al.
Bkm Firmke et al.
Cellular adaptation to hypoxia is essential for maintaining function and survival. While most hypoxic responss are mediated by hypoxia‑inducible factor signaling, the oxygen‑dependent ADO-RGS (2‑Aminoethanethiol-Dioxygenase-Regulator of ...
Cholesterol-depleting dextrin depolarizes sarcolemma: the contribution of sodium / calcium channels and membrane integrity [0.03%]
胆固醇消耗的糊精使肌膜去极化：钠/钙通道和膜完整性的贡献
Arina D Tupitsyna,Nikita S Fedorov,Venera R Khabibrakhmanova et al.
Arina D Tupitsyna et al.
Skeletal muscle function is critically dependent on the metabolism of cholesterol and its sarcolemmal levels. Decreased cholesterol availability is associated with various pathological conditions, causing muscle weakness. Here, we tested th...
Inhibition of (interstitial) P2Y6 receptors attenuates fibrosis progression [0.03%]
抑制（间质）P2Y6受体可减轻纤维化进程
Lena Marie Süß,Anna Petzendorfer,Minh Linh Tran et al.
Lena Marie Süß et al.
Chronic kidney disease (CKD) affects over 850 million people worldwide and is characterized by progressive renal fibrosis driven by activated interstitial fibroblasts. Signaling by extracellular nucleotides and P2 receptors plays an importa...
Renal NHE3 is required to limit hypokalemia and metabolic acidosis during dietary potassium deficiency [0.03%]
肾NHE3在限制饮食缺钾引起的低血钾和代谢性酸中毒方面的必要性
Jennifer Nogueira Coelho,Natalie Hayslip,Rebecca Zoe Halter et al.
Jennifer Nogueira Coelho et al.
The sodium-hydrogen exchanger isoform 3 (NHE3) is a critical mediator of proximal tubule and thick ascending limb Na+ reabsorption and H+/NH4+ secretion, yet the physiological implications of its upregulation during low K+ intake remain poo...
Sevil Arabacı Tamer,Gamze Güney Eskiler,Feriha Ercan et al.
Sevil Arabacı Tamer et al.
Putative gastroprotective effects of xenin-25 were investigated in an indomethacin-induced acute ulcer model. Male Sprague-Dawley rats were randomly assigned to control, saline-treated ulcer, xenin-25-treated ulcer groups. Gastric ulcer was...
Biphasic regulation of myogenesis by ALDH2, aldosterone, and oxidative stress [0.03%]
ALDH2、醛固酮和氧化应激对肌细胞生成的双相调控作用
José Emmanuel Martínez-Cortés,Maikel Valle-Clara,Damaso Fernández-Hernández et al.
José Emmanuel Martínez-Cortés et al.
Aldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme that metabolizes 4-hydroxynonenal (4-HNE), a lipoperoxidation-derived aldehyde that promotes oxidative stress. ALDH2 is therefore considered part of the antioxidant defense. On the ...
First-in-human to proof-of-concept: why experimental medicine studies remain essential in human physiology and drug development [0.03%]
从首个人体试验到概念验证：实验医学研究在人体生理学和药物开发中仍然必不可少的原因
Robert J Unwin,Benjamin Challis,Carsten Wagner et al.
Robert J Unwin et al.
Experimental medicine studies, small, mechanistically focused investigations, have historically driven key discoveries in human physiology and pharmacology. Despite their foundational role, these studies are increasingly marginalised in tod...