Activation of the alternative complement pathway and its relevance for sodium retention in experimental nephrotic syndrome [0.03%]
补体旁路途径激活及在实验性肾病综合征钠潴留中的作用
Daniel Essigke,M Zaher Kalo,Lingsi Kong et al.
Daniel Essigke et al.
The complement component C3, factor B (FB) and factor D (FD) belong to the alternative complement pathway and have been identified in urine samples from nephrotic mice. However, it is not yet known whether these factors are involved in medi...
Massimiliano Zaniboni
Massimiliano Zaniboni
Modern cardiac electrophysiology is largely focused on global electrical properties of tissue, frequently assessed by extracellular electrical recordings or optical mapping, whereas studies on the microscopic nature of action potential cond...
Modulation of cardiac contractility and redox balance via cannabinoid type II receptor activation in healthy rats [0.03%]
大麻素受体II型激活调节健康大鼠心肌收缩力和氧化还原平衡
Suzana Luisa Alves Fernandes,Yan Costa Gonçalves,Francisco Tadeu Rantin et al.
Suzana Luisa Alves Fernandes et al.
The activation of cannabinoid receptor type II (CB2r) has been demonstrated to provide cardioprotective benefits against heart diseases. Nevertheless, the physiological effects of CB2r activation in healthy myocardial tissue remain poorly u...
Impact of dietary composition on behavioural expression and gut microbiome dynamics in zebrafish [0.03%]
饮食组成对斑马鱼行为表达及肠道微生物群动态的影响
Dhanusha Sivarajan,Vidya Pothayi,Sebastian Chempakassery Devasia et al.
Dhanusha Sivarajan et al.
Diet is a key physiological factor shaping brain function and gut microbiota, which together form the dynamic gut-brain axis. This bidirectional communication system plays a pivotal role in regulating behavioural outcomes. Therefore, it is ...
Robert G Hahn
Robert G Hahn
Recent kinetic studies show that the interstitial space contains two functional fluid compartments. This study explores the prerequisites for accumulation of infused crystalloid fluid in the remote slow-exchange space ("third fluid space¨,...
ER stress inhibitor 4PBA attenuates hindlimb unloading-induced cardiac mitochondrial and metabolic dysfunction [0.03%]
自噬诱导剂4PBA缓解失载所致心脏线粒体和代谢功能障碍
Firdos Ahmad,Anupriya Sinha,Asima Karim et al.
Firdos Ahmad et al.
Macrophages in metaflammation - fueling chronic inflammation in metabolic disease [0.03%]
代谢性疾病中慢性炎症的驱动因素——元炎症巨噬细胞
Ronja Kardinal,Dagmar Wachten
Ronja Kardinal
Obesity is a leading global health issue, closely associated with a chronic low-grade inflammation termed metaflammation. Metaflammation is driven by immune cell reprogramming, particularly of macrophages. In white adipose tissue (WAT), obe...
An in-depth look at shallow-water walking: the mechanical determinants of the energy metabolic cost of shallow water walking in humans [0.03%]
浅谈浅水行走：人体在浅水环境中行进时能量代谢成本的力学决定因素分析
André Ivaniski-Mello,Alberto Enrico Minetti,Flávia Gomes Martinez et al.
André Ivaniski-Mello et al.
Human locomotion in water involves unique forces (buoyancy, drag) influencing metabolic cost. However, a validated model integrating these forces to predict the cost of transport (COT) during shallow water walking (SWW) is lacking, and ener...
Marvin J A Meyer,George Oprita,Tabea C Fricke et al.
Marvin J A Meyer et al.
The ion channel TRPV2 has multiple roles in immunology, cancer, cardiovascular function and pain signaling. However, only few endogenous modulators of TRPV2 have been described. The phospholipase A2 (PLA2)-derived lipid lysophosphatidylchol...