Protective effects of vitamin E and quercetin against MDMA-induced cardiac and hematological dysfunction in male wistar rats [0.03%]
Ayodeji Folorunsho Ajayi,David Tolulope Oluwole,Moses Agbomhere Hamed et al.
Ayodeji Folorunsho Ajayi et al.
Proximal TGF-β Signaling in Chronic Injury: from a notorious fibrotic factor to a repair ally [0.03%]
Stellor Nlandu Khodo
Stellor Nlandu Khodo
Transforming growth factor beta (TGF-β) is a pleiotropic factor that plays a key role in the pathophysiology of chronic kidney disease (CKD). However, targeting TGF-β inhibition failed to mitigate CKD in practice. The proximal tubule (PT)...
Michael J M Fischer,Peter W Reeh
Michael J M Fischer
Active bile acid metabolism could contribute to muscle preservation in hibernating bears via the TGR5 pathway [0.03%]
Reiko Nakao,Lydie Humbert,Isabelle Chery et al.
Reiko Nakao et al.
Sex-sensitive and insensitive endocrine responses and infradian changes while trekking in the Himalayas [0.03%]
喜马拉雅远足期间的性敏感和非敏感内分泌反应及亚月周期变化
Danilo Bondi,Sofia Bonan,Simone Cantarelli et al.
Danilo Bondi et al.
Various studies have explored the effects of altitude hypoxia on hormonal changes. However, most research has been conducted on small samples and focused solely on male subjects. This project aimed to examine the effects of high-altitude tr...
Pathophysiology of homocysteine: insights into ion channel dysfunction [0.03%]
同型半胱氨酸的病理生理学：离子通道功能障碍的新见解
Nikola Chmúrčiaková,Robin N Stringer,Leoš Cmarko et al.
Nikola Chmúrčiaková et al.
Homocysteine is a non-proteinogenic amino acid formed during the metabolism of methionine to cysteine and plays a critical role in maintaining cellular homeostasis. Although multiple enzymatic pathways tightly regulate homocysteine levels, ...
Upregulation of T-type voltage-dependent Ca²⁺ channels in activated hepatic stellate cells promotes liver fibrosis in metabolic dysfunction-associated steatohepatitis [0.03%]
代谢功能障碍相关steatohepatitis肝星状细胞活化促进肝纤维化的新机制：T型电压门控钙通道的上调作用
Naoki Kawata,Rubii Kondo,Mizuki Hashizume et al.
Naoki Kawata et al.
Tanecia Mitchell,Vivek Verma,Abul Fajol et al.
Tanecia Mitchell et al.
The kidney is a major regulator of phosphate metabolism. The body can lower systemic phosphate levels by increasing renal phosphate excretion, and kidney injury results in elevated serum phosphate concentrations (hyperphosphatemia). Chronic...
Targeting hypertension through natural phenolics: The multifaceted role of cinnamic acid and its derivatives [0.03%]
天然酚类化合物抗高血压作用及机制研究——以咖啡酸及其衍生物为例
Samuel S P de Araujo,Brenda L B Dos Santos,Waldilleny R A de Moura et al.
Samuel S P de Araujo et al.
Hypertension is a serious global public health problem that significantly increases the risk of cardiovascular diseases. Its etiology involves inflammatory processes, oxidative stress, and imbalances in blood pressure (BP) regulatory system...
DNase I as a probe for unpolymerized actin: revisiting a classic tool for nuclear actin research [0.03%]
核内核膜下存在可溶的未聚合并与DNA结合的G-肌动蛋白分子簇：经典工具DNase I的新角色
Anika Göpel,Laura Bauer,Dörthe M Katschinski et al.
Anika Göpel et al.
Actin is a key component of the cytoskeleton and also plays diverse roles within the cell nucleus. While polymerized F-actin can be detected using a wide range of probes, reliable methods to identify unpolymerized (“G-”) actin in fixed ce...