Immature olfactory sensory neurons are intrinsically excitable and show maturation-dependent changes in voltage-gated Na+ and K+ currents [0.03%]
不成熟的嗅觉感觉神经元的内在兴奋性和电压门控钠离子和钾离子电流的成熟依赖性变化
Chiara Ricci,Cesar Adolfo Sánchez Triviño,Uday Rangaswamy et al.
Chiara Ricci et al.
Olfactory sensory neurons (OSNs) detect odorants and send electrical signals to glomeruli in the olfactory bulb. Unlike most neurons, OSNs are continuously regenerated throughout life and immature neurons contribute to odorant-evoked respon...
Preliminary evidence of extrarenal sodium storage in a large mammal: implications for comparative physiology and hypertension research : Running: Sodium storage in cattle [0.03%]
大型哺乳动物体外肾钠储存的初步证据：比较生理学和高血压研究的意义：跑步中的牛体内的钠储存
Andrew J Abraham,Ethan S Duvall,Callum Leese et al.
Andrew J Abraham et al.
Under conditions of dietary sodium (Na+) excess, the kidneys may fail to adequately excrete Na+, potentially compromising blood pressure homeostasis. Body tissues, such as skin, can offer sites of short-term extrarenal Na+ storage and previ...
Integrated effects of altered action potentials and calcium release on skeletal muscle force generation in transgenic Huntington's disease mice [0.03%]
转基因亨廷顿病小鼠骨骼肌动作电位和钙释放改变对肌肉收缩力的综合影响
Daniel R Miranda,Steven R A Burke,Pooneh Hajmirza Mohammadi Kamalabadi et al.
Daniel R Miranda et al.
Huntington’s disease (HD) is a movement disorder commonly recognized as being neurodegenerative. An increasing number of studies also show primary HD dysfunction in multiple tissues, consistent with the widespread expression of the mutated...
Active salt transport and countercurrent exchange as the basis of urine concentration: a proposal grounded on the microanatomy of the renal medulla [0.03%]
主动盐转运和逆流交换是尿液浓缩的基础：基于肾脏髓质微解剖结构的假说
Wilhelm Kriz,Brigitte Kaissling,Michel Le Hir
Wilhelm Kriz
The longitudinal arrangement of tubules and vessels in the renal medulla has in the early fifties of the last century given birth to the concept of countercurrent multiplication (CCM). Since then, enormous research has been expended, but a ...
Just a little prick: careful cell contacts enabled by ceramic nanostraws [0.03%]
一丝刺痛：陶瓷纳米吸管使细胞接触更轻松
Noah Brechmann,Tamara Büttner,Bernd Walkenfort et al.
Noah Brechmann et al.
Nanostraw arrays represent a novel and promising approach for the controlled delivery of substances into cells characterized by very little cellular activation or damage. Herein, we describe a sensitive strategy to establish intracellular c...
Tachykinergic signaling mediated by NK1 receptors in the respiratory parafacial region drives respiratory output and contributes to the chemoreflex response to CO2 [0.03%]
速激肽能信号通过呼吸副延髓区域的NK1受体驱动呼吸输出并参与CO2介导的化学反射反应
Octávio A C Maia,Luiz M Oliveira,Jan-Marino Ramirez et al.
Octávio A C Maia et al.
The respiratory parafacial region (pFRG) contributes critically to central chemoreception, CO2/H+ homeostasis and the regulation of all major components of the respiratory rhythm. The respiratory rhythm is also modulated by the neuropeptide...
The progression of triple-negative breast cancer is linked to a gradual decrease of the BK channel in the plasma membrane and an increase in intracellular structures [0.03%]
BK通道与三阴性乳腺癌的进展关系研究
Rodrigo Zamora-Cárdenas,Ana Laura López-Serrano,Tania Ferrer et al.
Rodrigo Zamora-Cárdenas et al.
Big Potassium (BK) channels are gated by both the membrane potential and intracellular Ca2+, and hence they have multiple physiological roles, from canonical control of cellular excitability to modulate cell metabolism, proliferation, and g...
Acid-Base homeostasis in the brain: regional heterogeneity and different Acid-Base transporters [0.03%]
大脑酸碱平衡：区域异质性和不同的酸碱转运蛋白
Masoumeh Kourosh-Arami,Alireza Komaki
Masoumeh Kourosh-Arami
The brain employs a sophisticated and multi-layered system to maintain its delicate acid-base balance, ensuring optimal conditions for neuronal and glial function. This intricate regulation involves a combination of chemical buffering, acti...
Electroacupuncture as a therapeutic intervention for obesity: mechanisms and implications [0.03%]
电针治疗肥胖的作用机制及意义研究综述
Lili Hong,Yi An,Xiaoyuan Feng et al.
Lili Hong et al.
Obesity, a prevalent metabolic disease characterized by chronic systemic inflammation and dysregulated energy homeostasis, contributes to comorbidities such as type 2 diabetes and non-alcoholic fatty liver disease. Despite advancements in l...