The impact of different exercise types on cognitive function in patients with multiple sclerosis: a systematic review and network meta-analysis [0.03%]
不同运动类型对多发性硬化患者认知功能影响的系统评价和网络 meta 分析
Xingyi Su,Zhong Zheng,Fengyuan Yu et al.
Xingyi Su et al.
Objective: Numerous studies have demonstrated the beneficial effects of exercise on cognitive function in individuals with multiple sclerosis. However, existing research findings are inconsistent, and no study has yet ide...
The microlesion effect is associated with global cognitive impairment and predicts motor outcomes after subthalamic deep brain stimulation in Parkinson's disease [0.03%]
微梗死效应与帕金森病丘脑底核电刺激后的全局认知损害有关并可预测运动结果
Liying Liang,Jiahao Zhao,Hui Wang et al.
Liying Liang et al.
Objective: A postoperative microlesion effect (MLE) is regarded as a reliable predictor of the subsequent efficacy of deep brain stimulation of the subthalamic nucleus (STN-DBS) treatment. However, the predictive ability ...
Pedigree analysis and genetic inheritance of fatal familial insomnia (FFI) in a Portuguese multigenerational family [0.03%]
葡萄牙多代家族 Fatal Familial Insomnia（FFI）的系谱分析和遗传特征
Angela Da Silva Correia,Ines Laginha,Susana Guimaraes et al.
Angela Da Silva Correia et al.
Fatal familial insomnia (FFI) is a rare, autosomal dominant prion disease caused by a mutation in the PRNP gene, leading to the misfolding of the cellular prion protein (PrPC) into its pathogenic form (PrPSc). This results in neurodegenerat...
Efficacy and safety of ublituximab for relapsing multiple sclerosis patients: current evidence and expert opinion [0.03%]
用于复发型多发性硬化症患者的ublituximab疗效和安全性：现有证据与专家意见
Paolo Preziosa,Vincenzo Brescia Morra,Marco Capobianco et al.
Paolo Preziosa et al.
Ublituximab, a newly launched anti-CD20 monoclonal antibody, represents a substantial advancement in the treatment landscape for relapsing multiple sclerosis (RMS). Its unique glycoengineered design enhances antibody-dependent cellular cyto...
JC virus PCR assay reporting for PML: promises, perils, and pitfalls [0.03%]
JC病毒PCR检测在PML中的应用：前景、风险与误区
Jagannadha Avasarala,Suhas Gangadhara
Jagannadha Avasarala
One of the most devastating central nervous system infections, progressive multifocal leukoencephalopathy (PML), is caused by the JC virus (JCV). In immunosuppressed patients, PML is a well-recognized complication recognized by clinicians a...
Early subtypes and progressions of progressive supranuclear palsy: a data-driven brain bank study [0.03%]
基于数据库的进行性核上性麻痹早期亚型及进展研究
Daisuke Ono,Hiroaki Sekiya,Nikhil B Ghayal et al.
Daisuke Ono et al.
Background: Progressive supranuclear palsy (PSP) is typically characterized by vertical supranuclear gaze palsy and early falls, referred to as Richardson's syndrome (PSP-RS). Other presentations include postural instabil...
Xing Guo,Ruizhu Yue,Zhenwu Cui et al.
Xing Guo et al.
The past several decades have yielded deeper insights into the multifactorial pathogenesis and intervention strategies of Alzheimer's disease (AD). AD pathogenesis involves a complex interplay of multiple factors, where the amyloid-beta hyp...
Andrew J Larner
Andrew J Larner
Five-year prospective outcomes of medical management and microvascular decompression in trigeminal neuralgia [0.03%]
三叉神經痛的醫學觀察和微血管減壓五年前瞻性預後研究
Jacob Worm,Tone Bruvik Heinskou,Per Rochat et al.
Jacob Worm et al.
Background: Trigeminal neuralgia is a severe facial pain disorder with major impact on quality of life. Long-term prospective data comparing medical and surgical treatments remain scarce. This study compared 5-year outcom...
Observational Study
Journal of neurology. 2025 Oct 16;272(10):701. DOI:10.1007/s00415-025-13447-9 2025
Retinal microvascular differences between multiple sclerosis and neuromyelitis optica spectrum disorder: a cross-sectional study with diagnostic modeling [0.03%]
多发性硬化和视神经脊髓炎谱系病的视网膜微血管差异：具有诊断模型的横断面研究
Ruishan Liu,Lingyao Kong,Le Cao et al.
Ruishan Liu et al.
Background and objectives: Retinal alterations in multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) remain unclear, especially the specific patterns and extent of microvascular change. This study ...