FOXM1 plays a role in autophagy by transcriptionally regulating Beclin-1 and LC3 genes in human triple-negative breast cancer cells [0.03%]
FOXM1通过转录调控人类三阴性乳腺癌细胞中的BCL2基因和LC3基因在自噬中发挥作用
Zuhal Hamurcu,Nesrin Delibaşı,Ufuk Nalbantoglu et al.
Zuhal Hamurcu et al.
Triple-negative breast cancer (TNBC) is associated with poor prognosis owing to its aggressive and heterogeneous nature, and the lack of therapeutic targets. Although Forkhead Box M1 (FOXM1) is one of the most important oncogenes contributi...
MicroRNA-145 targets Smad1 in endometrial stromal cells and regulates decidualization in rat [0.03%]
MicroRNA-145靶向调控Smad1在大鼠子宫内膜基质细胞的作用及机制研究
Vijay K Sirohi,Kanchan Gupta,Radhika Kapoor et al.
Vijay K Sirohi et al.
Decidualization of endometrial stromal cells is the pre-requisite for the embryo implantation and establishment of pregnancy. Although known to be regulated by several factors, the process of regulation of decidualization by miRNAs is large...
MOTS-c peptide regulates adipose homeostasis to prevent ovariectomy-induced metabolic dysfunction [0.03%]
MOTS-c肽通过调节脂肪稳态预防卵巢切除引起的代谢紊乱
Huanyu Lu,Ming Wei,Yue Zhai et al.
Huanyu Lu et al.
The postmenopausal state is associated with an increased risk of metabolic disorder including reduced energy expenditure and weight gain, leading to higher cardiovascular and cancer risks among other diseases. Mitochondrial-derived peptide ...
AMPK agonist AICAR ameliorates portal hypertension and liver cirrhosis via NO pathway in the BDL rat model [0.03%]
AICAR通过NO通路改善胆管结扎大鼠门脉高压和肝硬化
Liangshuo Hu,Lin Su,Zhixia Dong et al.
Liangshuo Hu et al.
Recent studies have indicated that the Adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) pathway is closely involved in liver fibrosis and other fibrotic diseases. However, whether targeting the AMPK pathway can rescue liver ...
MiR-449a-5p mediates mitochondrial dysfunction and phenotypic transition by targeting Myc in pulmonary arterial smooth muscle cells [0.03%]
MiR-449a-5p通过靶向肺动脉平滑肌细胞中的Myc介导线粒体功能障碍和表型转换
Chen Zhang,Cui Ma,Lixin Zhang et al.
Chen Zhang et al.
MicroRNAs have been considered to participate in pulmonary arterial hypertension (PAH) and regulate numerous disease pathways in pulmonary vasculature. However, the molecular role in the pathologies has not yet been fully uncovered, particu...
Wanning Wang,Weixia Sun,Yanli Cheng et al.
Wanning Wang et al.
Diabetic nephropathy (DN) is a research priority for scientists around the world because of its high prevalence and poor prognosis. Although several mechanisms have been shown to be involved in its pathogenesis and many useful drugs have be...
Are glutamate transporters neuroprotective or neurodegenerative during cerebral ischemia? [0.03%]
在脑缺血期间，谷氨酸转运蛋白是神经保护性的还是神经毒性的？
Li-Nan Zhang,Liang Hao,Yu-Song Guo et al.
Li-Nan Zhang et al.
The accumulation of glutamate (Glu) in the synaptic cleft during cerebral ischemia triggers the death of neurons, causing mental or physical handicap. However, the mechanisms of the alteration in Glu homeostasis and the imbalance between th...
Follicular helper T cell and memory B cell immunity in CHC patients [0.03%]
CHC患者体内滤泡辅助性T细胞和记忆B细胞的免疫反应
Yong Liu,Huifan Ji,Pingwei Zhao et al.
Yong Liu et al.
Chronic hepatitis C (CHC) is associated with biological activity of T follicular helper (Tfh) cells and memory B cells (MBCs). However, the nature of Tfh cell subsets that are responsible for MBCs in CHC patients has not been evaluated. Thi...
IDH-1 deficiency induces growth defects and metabolic alterations in GSPD-1-deficient Caenorhabditis elegans [0.03%]
IDH-1缺陷可诱导GSPD-1缺陷秀丽隐杆线虫生长受阻及代谢改变
Hung-Chi Yang,Hsiang Yu,You-Cheng Liu et al.
Hung-Chi Yang et al.
NADPH is a reducing equivalent that maintains redox homeostasis and supports reductive biosynthesis. Lack of major NADPH-producing enzymes predisposes cells to growth retardation and demise. It was hypothesized that double deficiency of the...
Suppression of Syk activation by resveratrol inhibits MSU crystal-induced inflammation in human monocytes [0.03%]
白藜芦醇通过抑制Syk活化来抑制尿酸盐结晶诱导的人单核细胞炎症反应
Yeon-Ho Chung,Hee Young Kim,Bo Ruem Yoon et al.
Yeon-Ho Chung et al.
Monosodium urate (MSU) crystals are an endogenous sterile particulate that has been identified as a potent damage-associated molecular pattern (DAMP). In humans, the induction of IL-1β production through MSU-induced NLRP3 inflammasome acti...