A bezafibrate bearing Pt(IV) prodrug triggers ferroptosis via modulating lipid metabolism in lung cancer cells [0.03%]
贝扎匹ibrate类Pt(IV)前药通过调节肺癌细胞的脂质代谢触发铁死亡
Neng Wan,Xuan-Lin Ren,Xiang-Yu Ma et al.
Neng Wan et al.
James P McEvoy
James P McEvoy
Advances in bioelectronic and renewable energy technologies make it important for undergraduate students to learn about bioelectrochemistry, and courses in the chemical and biological sciences provide opportunities for them to do so. This r...
Looking backward to move forward: a chemist's perspective on the future of radiopharmaceuticals [0.03%]
展望未来，回首过去：放射性药物的化学视角
Stacey E Rudd
Stacey E Rudd
Nuclear medicine has existed since the 1940s, but the clinical approval of a handful of new radiopharmaceutical agents in the last few years has thrust the field into the spotlight of modern cancer research. Now that radiopharmaceuticals ha...
Olefin metathesis of phospholipids by Ruthenium-based catalysts in solution and on liposomes under biologically relevant conditions [0.03%]
基于钌的催化剂在溶液和脂质体上生物相关条件下的磷脂烯烃元成合
Pina Eichert,Huriye Deniz Uzun,Sascha Heinrich et al.
Pina Eichert et al.
The last decade has seen a lot of interest in classical organometallic catalysis performed intracellularly, or at least under biological conditions (37 °C, air, water). One such classical reaction is olefin metathesis (OM), which is extrem...
Oxidative environments promote the formation of detergent-resistant IgG aggregates mediated by Cu(II) assessed by optical density: implications in vivo [0.03%]
氧化环境通过光学密度促进由Cu(II)介导的耐洗涤剂免疫球蛋白G聚集的形成：体内意义
Christian Saporito-Magriña,Lila Lopez-Montañana,María Laura Facio et al.
Christian Saporito-Magriña et al.
Protein proclivity to aggregation leads to the formation of insoluble aggregates which slowly build up over the years within blood and different tissues. In humans, the content of these detergent resistant aggregates has been found increase...
Decoding the mechanism for cytotoxicity in thiolato-bridged triosmium carbonyl clusters: from serum reactivity to cellular impact [0.03%]
硫醇桥联三锇羰基簇引发细胞毒性的机制解析：从血清反应到细胞影响
Xin Liang,Hélène C Bertrand,Nicolas Delsuc et al.
Xin Liang et al.
Mechanism of action (MoA) studies on the cytotoxic thiolato-bridged triosmium carbonyl clusters Os3(CO)10(μ-H)(μ-SR) (2) indicates that their cytotoxicity is associated with increased reactive oxygen species (ROS) generation, G2/M cell cy...
Detection of a clamp-shaped conformation of a neuronal nitric oxide synthase construct by pulsed EPR [0.03%]
脉冲EPR检测神经元型一氧化氮合成酶片段的夹状构象
Andrei V Astashkin,Yadav Prasad Gyawali,Ting Jiang et al.
Andrei V Astashkin et al.
Nitric oxide synthase (NOS) is an enzyme responsible for the production of nitric oxide in living organisms. Structurally, it is a homodimer composed of multiple domains connected by random coil tethers. The resulting structural flexibility...
Interactions of elongated dinuclear metallo-cylinders with DNA three-way and four-way junctions [0.03%]
延展性二核金属圆筒与DNA三路和四路接头的相互作用
Samuel J Dettmer,Hannah M P Stock,Michael J Hannon
Samuel J Dettmer
Non-canonical DNA structures play important roles in processing of the genetic code. Three-way (3WJ) and four-way (4WJ) junctions are dynamic, multi-stranded structures containing an open cavity at the centre. We have previously demonstrate...
A tris(pyrazolyl)-based model for the aminocyclopropane carboxylic acid oxidase and its behavior towards oxidants [0.03%]
一种三吡唑基丙氨酰羟基磺酸氧化酶模型及其对氧化剂的作用行为研究
Lars Müller,Charikleia Tzatza,Santina Hoof et al.
Lars Müller et al.
A low-molecular-weight analog of the 1-aminocyclopropane carboxylic acid oxidase (ACCO), [TpMesFeACC], 1, where the (His₂Asp)iron(II) moiety is mimicked by a hydrotris(3-mesitylpyrazol-1-yl)borato iron(II) unit, to which the natural substr...
The important interplay between metal ions and the intermediate filament protein vimentin [0.03%]
金属离子和中间丝蛋白波形蛋白之间的相互作用
Estely J Carranza,Dylan T Murray,Marie C Heffern
Estely J Carranza
Vimentin is a principal intermediate filament (IF) protein that is essential for maintaining cytoskeleton architecture and cellular mechanical integrity. Growing evidence is revealing that metal ions play critical roles in modulating the st...