Olefin metathesis of phospholipids by Ruthenium-based catalysts in solution and on liposomes under biologically relevant conditions [0.03%]
基于钌的催化剂在溶液和脂质体上生物相关条件下的磷脂烯烃元成合
Pina Eichert,Huriye Deniz Uzun,Sascha Heinrich et al.
Pina Eichert et al.
The last decade has seen a lot of interest in classical organometallic catalysis performed intracellularly, or at least under biological conditions (37 °C, air, water). One such classical reaction is olefin metathesis (OM), which is extrem...
Oxidative environments promote the formation of detergent-resistant IgG aggregates mediated by Cu(II) assessed by optical density: implications in vivo [0.03%]
氧化环境通过光学密度促进由Cu(II)介导的耐洗涤剂免疫球蛋白G聚集的形成：体内意义
Christian Saporito-Magriña,Lila Lopez-Montañana,María Laura Facio et al.
Christian Saporito-Magriña et al.
Protein proclivity to aggregation leads to the formation of insoluble aggregates which slowly build up over the years within blood and different tissues. In humans, the content of these detergent resistant aggregates has been found increase...
Decoding the mechanism for cytotoxicity in thiolato-bridged triosmium carbonyl clusters: from serum reactivity to cellular impact [0.03%]
硫醇桥联三锇羰基簇引发细胞毒性的机制解析：从血清反应到细胞影响
Xin Liang,Hélène C Bertrand,Nicolas Delsuc et al.
Xin Liang et al.
Mechanism of action (MoA) studies on the cytotoxic thiolato-bridged triosmium carbonyl clusters Os3(CO)10(μ-H)(μ-SR) (2) indicates that their cytotoxicity is associated with increased reactive oxygen species (ROS) generation, G2/M cell cy...
Detection of a clamp-shaped conformation of a neuronal nitric oxide synthase construct by pulsed EPR [0.03%]
脉冲EPR检测神经元型一氧化氮合成酶片段的夹状构象
Andrei V Astashkin,Yadav Prasad Gyawali,Ting Jiang et al.
Andrei V Astashkin et al.
Nitric oxide synthase (NOS) is an enzyme responsible for the production of nitric oxide in living organisms. Structurally, it is a homodimer composed of multiple domains connected by random coil tethers. The resulting structural flexibility...
Interactions of elongated dinuclear metallo-cylinders with DNA three-way and four-way junctions [0.03%]
延展性二核金属圆筒与DNA三路和四路接头的相互作用
Samuel J Dettmer,Hannah M P Stock,Michael J Hannon
Samuel J Dettmer
Non-canonical DNA structures play important roles in processing of the genetic code. Three-way (3WJ) and four-way (4WJ) junctions are dynamic, multi-stranded structures containing an open cavity at the centre. We have previously demonstrate...
A tris(pyrazolyl)-based model for the aminocyclopropane carboxylic acid oxidase and its behavior towards oxidants [0.03%]
一种三吡唑基丙氨酰羟基磺酸氧化酶模型及其对氧化剂的作用行为研究
Lars Müller,Charikleia Tzatza,Santina Hoof et al.
Lars Müller et al.
A low-molecular-weight analog of the 1-aminocyclopropane carboxylic acid oxidase (ACCO), [TpMesFeACC], 1, where the (His₂Asp)iron(II) moiety is mimicked by a hydrotris(3-mesitylpyrazol-1-yl)borato iron(II) unit, to which the natural substr...
The important interplay between metal ions and the intermediate filament protein vimentin [0.03%]
金属离子和中间丝蛋白波形蛋白之间的相互作用
Estely J Carranza,Dylan T Murray,Marie C Heffern
Estely J Carranza
Vimentin is a principal intermediate filament (IF) protein that is essential for maintaining cytoskeleton architecture and cellular mechanical integrity. Growing evidence is revealing that metal ions play critical roles in modulating the st...
Novel phenanthroline-based ruthenium complex as a promising antimicrobial agent [0.03%]
一种有前景的抗菌剂苯并咪唑钌配合物的研究
Pedro L N Teixeira,Ana C S Gondim,Tercio F Paulo et al.
Pedro L N Teixeira et al.
A novel ruthenium(II) compound, cis-[Ru(phen)2(4-bzpy)(Cl)](PF6) (complex I), where phen = 1,10-phenanthroline and 4-bzpy = 4-benzoylpyridine, was synthesized and fully characterized using electrochemical and spectroscopic methods, and its ...
Biogenic silver nanoparticles from chamomile incorporated in hydrogels for high transparent non-infectiveness contact lenses [0.03%]
一种新型高透明无菌隐形眼镜：羟丙甲纤维素/聚乙烯醇生物银纳米复合材料抗菌水凝胶及其制备方法
Panagiotis K Raptis,Christina N Banti,Christina Papachristodoulou et al.
Panagiotis K Raptis et al.
Chamomile extract (CHA) was employed in the synthesis of silver nanoparticles (AgNPs(CHA)). These nanoparticles were incorporated into a hydroxyethyl methacrylate (pHEMA) matrix during polymerization at concentrations of 1 mg/mL (pHEMA@AgNP...
Biplab K Maiti,Isabel Moura,José J G Moura
Biplab K Maiti
Magnetic interactions between iron-sulfur (Fe/S) clusters and transition metal centers such as nickel, molybdenum, and copper play a central role in the function of key metalloenzymes. These interactions, which arise from electronic couplin...