Assessment of regulatory T cells (Tregs) and Foxp3 methylation level in chronic myeloid leukemia patients on tyrosine kinase inhibitor therapy [0.03%]
酪氨酸激酶抑制剂治疗的慢性髓性白血病患者调节性T细胞(Tregs)和Foxp3甲基化水平评估
Shahla&#x;a Fadhil Sabir,Bassam Francis Matti,Wifaq Mahmood Ali Alwatar
Shahla&#x;a Fadhil Sabir
The key cell population permits cancer cells to avoid immune-surveillance is regulatory T cells (Tregs). This study evaluates the level of Tregs in chronic myeloid leukemia (CML) patients and the effect of Tyrosine kinase inhibitor (TKI) on...
Anshika Srivastava,Jill A Hollenbach
Anshika Srivastava
The worldwide coronavirus disease 2019 pandemic was sparked by the severe acute respiratory syndrome caused by coronavirus 2 (SARS-CoV-2) that first surfaced in December 2019 (COVID-19). The effects of COVID-19 differ substantially not just...
Unfavorable immunotherapy plus tyrosine kinase inhibition outcome of metastatic renal cell carcinoma after radical nephrectomy with increased ADAM9 expression [0.03%]
根治性肾切除术后ADAM9表达增加的转移性肾细胞癌行免疫治疗联合酪氨酸激酶抑制效果不佳
Xianglai Xu,Ying Wang,Zhaoyi Chen et al.
Xianglai Xu et al.
Immunotherapy plus tyrosine kinase inhibitor (IO-TKI) has become the standard first-line therapy for advanced renal cell carcinoma (RCC). However, the modest response rate of IO-TKI therapy and the absence of biomarkers limited the selectio...
Carene Anne Alene Ndong Sima,Dayna Smith,Desiree C Petersen et al.
Carene Anne Alene Ndong Sima et al.
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains the leading cause of death due to a single bacterial agent, with approximately 10.6 million people developing active disease and 1.6 million deaths reported globally in ...
The antigen recognition portion of African buffalo class I MHC is highly polymorphic, consistent with a complex pathogen challenge environment, and the 3' region suggests distinct haplotype configurations [0.03%]
非洲水牛主要组织相容性复合物I类分子抗原识别部分的高度多态性与复杂病原体挑战环境一致，3'区表明具有不同的单倍型配置
Isaiah Obara,Ard Nijhof,Patrick Atimnedi et al.
Isaiah Obara et al.
African buffalo (Syncerus caffer) have been distinct from the Auroch lineage leading to domestic cattle for 5 million years, and are reservoirs of multiple pathogens, that affect introduced domestic cattle. To date, there has been no analys...
X-linked hyper-immunoglobulin M syndrome harboring a novel CD40-ligand gene mutation: a case report [0.03%]
携带新型CD40配体基因突变的X连锁高免疫球蛋白M综合征1例报告
Rahul Ramachandran,Yamini Krishnan,Parminder Singh et al.
Rahul Ramachandran et al.
The X-linked hyper-IgM syndrome (X-HIGM1) is a rare primary immunodeficiency disorder (PID) caused by mutations in the gene encoding the CD154 protein, also known as CD40 ligand (CD40LG). X-HIGM1 is characterized by normal or elevated serum...
Case Reports
Immunogenetics. 2023 Apr;75(2):191-194. DOI:10.1007/s00251-022-01289-y 2023
Bioinformatics analysis of structural protein to approach a vaccine candidate against Vibrio cholerae infection [0.03%]
结构蛋白的生物信息学分析以寻找预防霍乱弧菌感染的疫苗候选对象
Elijah Kolawole Oladipo,Olawumi Elizabeth Akindiya,Glory Jesudara Oluwasanya et al.
Elijah Kolawole Oladipo et al.
The bacteria Vibrio cholerae causes cholera, an acute diarrheal infection that can lead to dehydration and even death. Over 100,000 people die each year as a result of epidemic diseases; vaccination has emerged as a successful strategy for ...
Distinct frequency patterns of LILRB3 and LILRA6 allelic variants in Europeans [0.03%]
欧洲人中LILRB3和LILRA6等位基因变异的不同频率模式
Arman A Bashirova,Wojciech Kasprzak,Colm O&#x;hUigin et al.
Arman A Bashirova et al.
The leukocyte immunoglobulin-like receptor (LILR)B3 and LILRA6 genes encode homologous myeloid inhibitory and activating orphan receptors, respectively. Both genes exhibit a strikingly high level of polymorphism at the amino acid level and ...
Age-dependent effect of the IFIH1/MDA5 gene variants on the risk of critical COVID-19 [0.03%]
IFIH1/MDA5基因变异对重症COVID-19影响的年龄依赖效应分析
María G Muñiz-Banciella,Guillermo M Albaiceta,Laura Amado-Rodríguez et al.
María G Muñiz-Banciella et al.
MDA5, encoded by the IFIH1gene, is a cytoplasmic sensor of viral RNAs that triggers interferon (IFN) antiviral responses. Common and rare IFIH1 variants have been associated with the risk of type 1 diabetes and other immune-mediated disorde...
HLA-G expression in Merkel cell carcinoma and the correlation with Merkel cell polyomavirus infection [0.03%]
Merkel细胞癌中的HLA-G表达及其与 Merkel细胞多瘤病毒的关系
L M Parra,B G C Sartori,D R Fernandes et al.
L M Parra et al.
Merkel cell carcinoma (MCC) is a rare aggressive neuroendocrine cutaneous carcinoma with a high mortality rate. The MCC etiology is not fully understood. Merkel cell-associated polyomavirus (MCPyV) was found in MCC patients, indicating a ri...