Age-dependent effect of the IFIH1/MDA5 gene variants on the risk of critical COVID-19
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MDA5, encoded by the IFIH1gene, is a cytoplasmic sensor of viral RNAs that triggers interferon (IFN) antiviral responses. Common and rare IFIH1 variants have been associated with the risk of type 1 diabetes and other immune-mediated disorders, and with the out... ...
