Mohammad Y Alshahrani,Zahraa AlKhafaje,Uday Abdul-Reda Hussein et al.
Mohammad Y Alshahrani et al.
Immunosenescence is a complex biological process characterized by progressive remodeling of immune function during aging, leading to increased susceptibility to infections, chronic inflammatory diseases, cancer, and reduced vaccine efficacy...
Causal relationship and pathogenic mechanism analysis of breast cancer and coronary heart disease based on mendelian randomization and transcriptome data analysis [0.03%]
基于孟德尔随机化和转录组数据分析的乳腺癌与冠心病的因果关系及发病机制探讨
Mingbin Xie,Yuanhong Wu,Xinyao Jin et al.
Mingbin Xie et al.
Breast cancer (BC) is closely linked to coronary heart disease (CHD), yet the genetic causal relationship and common driving mechanism between the two have not been fully elucidated. The purpose of this study is to infer the causal relation...
Genotype-phenotype correlations in autoimmune and autoinflammatory diseases: An NGS-based immunogenetic cohort study [0.03%]
自身免疫和自身炎症性疾病中基因型与表型的相关性：基于NGS的免疫遗传队列研究
Esra Çolak Geniş,Fethi Sırrı Çam
Esra Çolak Geniş
ObjectiveAutoimmune and autoinflammatory diseases (AIDs) represent a heterogeneous group of immune-mediated disorders characterized by dysregulated innate and adaptive immune responses. This study aimed to investigate the immunogenetic back...
Elevated interleukin-36γ and gene polymorphisms implicate novel risk in essential hypertension [0.03%]
升高的白细胞介素-36γ和基因多态性提示在原发性高血压中的新风险因素
Alishba Kainat,Fazlul Aziz Mian,Muhammad Asif Nawaz Khan et al.
Alishba Kainat et al.
Cytokines are crucial in regulating hypertension and vascular inflammation. The clinical significance of circulating IL-36γ levels and IL36G gene variants in relation to essential hypertension risk was assessed because IL-36γ has been ass...
Unraveling the genomic structures, conserved functional domains and evolutionary dynamics of beta-defensins in Bubalus bubalis and Ovis aries [0.03%]
解析水 buffalo 和羊 beta-防御素基因组结构、保守功能区及进化动力学
Sonam Yadav,Chanchal Rana,Fanny Josan et al.
Sonam Yadav et al.
Defensins are key innate immune proteins exhibiting pleiotropic functions such as antibacterial activity, antiviral activity, anti-inflammatory activity, immunomodulatory functions, and roles in reproduction. Genomic information inadequatel...
Genetic characterization of the TAPBP and its allelic association with BF2 in the chicken major histocompatibility complex [0.03%]
鸡主要组织相容性复合体中TAPBP的基因特征及其与BF2的等位基因关联
Roshani Fernando,Trisha Nicole Agulto,Eunjin Cho et al.
Roshani Fernando et al.
TAPBP is a key chaperone of the peptide-loading complex that facilitates peptide loading onto major histocompatibility complex class I (MHC I) molecules. This study characterized TAPBP alleles in Korean Native Chickens (KNCs), identified no...
Reconstructed amphibian heavy-chain constant regions support a mosaic origin of IgXA with IgY-like CH1-CH2, an intermediate CH3, and an IgM-like CH4 [0.03%]
重建的两栖动物重链恒定区支持IgXA具有类似于IgY的CH1-CH2、中间的CH3以及类似于IgM的CH4的镶嵌起源
Francisco Gambón-Deza
Francisco Gambón-Deza
The evolutionary relationship between amphibian IgM, IgY, and IgX/A-like antibodies has remained difficult to resolve, largely because repetitive heavy-chain loci are often incompletely or inconsistently annotated. In this study, I re-analy...
Climate factors and selection shape MHC class II diversity in a montane wild sheep (Ovis ammon) [0.03%]
气候因素和选择影响高山野生羊(Ovis ammon)的MHC II多样性
Zi-Yue Tian,Jin-Yi Li,Zhen-Yuan Cai et al.
Zi-Yue Tian et al.
Understanding how environmental heterogeneity drives spatially varying selection is key to deciphering adaptive evolution. The Major Histocompatibility Complex (MHC) provides an ideal model to study this process. We investigated the MHC cla...
Deciphering APOBEC1 in Avians: unravelling loss events and functional insights [0.03%]
鸟类APOBEC1的解析：揭秘丢失事件和功能见解
Aswin S Soman,Nagarjun Vijay
Aswin S Soman
In vertebrates, cytidine-to-uracil (C-to-U) editing is mediated by the AID/APOBEC family of deaminases, with APOBEC1 (A1) known to catalyse precise RNA editing of apolipoprotein B (apoB) transcripts in mammals. Despite its well-characterise...
Allelic diversity and selection at the MHC class I and class II in a long-distance migratory shorebird, the Hudsonian Godwit (Limosa haemastica) [0.03%]
迁徙性红腹滨鹬(Mach4H4/classI和classII区域的等位基因多样性及选择压力分析
Kiara Fernández,Nathan R Senner,James A Johnson et al.
Kiara Fernández et al.
The major histocompatibility complex (MHC) plays a central role in vertebrate adaptive immunity by encoding receptors that recognize pathogen-derived antigens. Migratory shorebirds, such as the Hudsonian Godwit (Limosa haemastica), encounte...