Allelic diversity and selection at the MHC class I and class II in a long-distance migratory shorebird, the Hudsonian Godwit (Limosa haemastica) [0.03%]
迁徙性红腹滨鹬(Mach4H4/classI和classII区域的等位基因多样性及选择压力分析
Kiara Fernández,Nathan R Senner,James A Johnson et al.
Kiara Fernández et al.
The major histocompatibility complex (MHC) plays a central role in vertebrate adaptive immunity by encoding receptors that recognize pathogen-derived antigens. Migratory shorebirds, such as the Hudsonian Godwit (Limosa haemastica), encounte...
Genetic and immunological determinants of Pemphigus vulgaris: integrative analysis of HLA-DRB1 and FCGR2B variants [0.03%]
寻常型天疱疮的遗传和免疫学决定因素：HLA-DRB1和FCGR2B变异体的综合分析
Burak Kaan Kasap,Bayram Toraman,Burçin Kurt et al.
Burak Kaan Kasap et al.
Pemphigus vulgaris (PV) is a rare autoimmune blistering disease mediated by pathogenic autoantibodies. Although both HLA and non-HLA loci contribute to disease susceptibility, their combined roles in immune regulation remain incompletely un...
Identification of gene conversion events in horse IGHV suggests preferential hotspots for diversification [0.03%]
在马免疫球蛋白变异区内鉴定到基因转换事件 基因多样化倾向于热点区域
Juliana Edelvacy Lima Pinto,João Henrique Brandão Gervásio,Joseph Chi-Fung Ng et al.
Juliana Edelvacy Lima Pinto et al.
The humoral immune response relies on a diverse antibody repertoire, which is expanded through processes such as somatic hypermutation, class-switch recombination and gene conversion. These processes are primarily mediated by activation-ind...
Genetic and evolutionary characteristics of the major histocompatibility complex class II β-chain genes of a large colony of captive king penguins (Aptenodytes patagonicus) [0.03%]
大型人工饲养帝企鹅(Aptenodytes patagonicus)主要组织相容性复合体II型β链基因的遗传及进化特征分析
Reona Dei,Yukie Miyazawa,Natsumi Ota et al.
Reona Dei et al.
The digital keystone: how artificial intelligence is reshaping HLA research and clinical practice [0.03%]
数字化关键点：人工智能如何重塑HLA研究和临床实践
Gamze Sonmez,Yigit Yazarkan,Deniz Cagdas
Gamze Sonmez
The human leukocyte antigen (HLA) system underpins allorecognition and shapes the response to infection, autoimmunity, and treatment response. Technological advances from serology to next-generation sequencing now enable full-gene character...
Evolution of CCR1 and CCR1L1 reveals complex duplication scenarios in Muroids and Ruminants [0.03%]
CCR1和CCR1L1的进化揭示了鼠形目和反刍动物中复杂的基因复制场景
João Pedro Marques,Ana Pinheiro,Pedro José Esteves
João Pedro Marques
Deciphering the genetic control of immune cell function at single-cell resolution: Disease-Specific Cis-eQTLs analysis of COVID-19 [0.03%]
单细胞分辨率免疫细胞功能的遗传调控解析——针对COVID-19的疾病特异性顺式eQTL分析
E I Romanova,D I Tychinin,A M Shaymardanov et al.
E I Romanova et al.
Class switched bovine ultralong CDR H3 amplicons versus canonical in immune and non-immune tissues [0.03%]
经典与类开关的牛超长CDR H3重链抗体免疫及非免疫组织amplicon测序分析
Karina L Hissen,Morgan Sheppard,Jeannine A Ott et al.
Karina L Hissen et al.
Within the bovine immune response, a distinct type of immunoglobulin (Ig), known as ultralong complementarity-determining region 3 (CDR3) antibodies, coexists alongside canonical Igs. These ultralong heavy chains (HC) feature a remarkable s...
NKG2D genetic variants and cancer susceptibility: Integrating case-control evidence with meta-analysis [0.03%]
NKG2D遗传变异与癌症易感性：病例对照证据的整合与meta分析
Nguyen Hoang Viet,Le Thanh Dong,Do Tung Dac et al.
Nguyen Hoang Viet et al.
Lymphomas are biologically heterogeneous malignancies with multifactorial etiologies involving genetic, environmental, and immune dysregulation. The functional variant rs1049174 SNP in the KLRK1 gene (encoding NKG2D) regulates NKG2D express...
Meta-Analysis
Immunogenetics. 2026 Jan 6;78(1):2. DOI:10.1007/s00251-025-01393-9 2026
Can the simple chicken MHC provide insight into the balance of autoimmunity and infectious disease? [0.03%]
简单的鸡MHC能否对自身免疫和传染病的平衡提供见解？
Enock M Mararo,Anastasia Goryanin,Jim Kaufman
Enock M Mararo
The major histocompatibility complex (MHC) plays a central role in immune responses, with strong links to both infectious disease resistance and autoimmune conditions. In typical mammals, such as humans, the MHC is large and complex, compri...