Class switched bovine ultralong CDR H3 amplicons versus canonical in immune and non-immune tissues [0.03%]
经典与类开关的牛超长CDR H3重链抗体免疫及非免疫组织amplicon测序分析
Karina L Hissen,Morgan Sheppard,Jeannine A Ott et al.
Karina L Hissen et al.
Within the bovine immune response, a distinct type of immunoglobulin (Ig), known as ultralong complementarity-determining region 3 (CDR3) antibodies, coexists alongside canonical Igs. These ultralong heavy chains (HC) feature a remarkable s...
NKG2D genetic variants and cancer susceptibility: Integrating case-control evidence with meta-analysis [0.03%]
NKG2D遗传变异与癌症易感性：病例对照证据的整合与meta分析
Nguyen Hoang Viet,Le Thanh Dong,Do Tung Dac et al.
Nguyen Hoang Viet et al.
Lymphomas are biologically heterogeneous malignancies with multifactorial etiologies involving genetic, environmental, and immune dysregulation. The functional variant rs1049174 SNP in the KLRK1 gene (encoding NKG2D) regulates NKG2D express...
Meta-Analysis
Immunogenetics. 2026 Jan 6;78(1):2. DOI:10.1007/s00251-025-01393-9 2026
Can the simple chicken MHC provide insight into the balance of autoimmunity and infectious disease? [0.03%]
简单的鸡MHC能否对自身免疫和传染病的平衡提供见解？
Enock M Mararo,Anastasia Goryanin,Jim Kaufman
Enock M Mararo
The major histocompatibility complex (MHC) plays a central role in immune responses, with strong links to both infectious disease resistance and autoimmune conditions. In typical mammals, such as humans, the MHC is large and complex, compri...
Necessity of individual VDJ-databases for annotating antibody heavy chain characteristics in non-human primates [0.03%]
非人灵长类抗体重链特征注释的VDJ数据库的必要性
Aafke Aartse,Jacco G J Bakx,Daniella Mortier et al.
Aafke Aartse et al.
Non-human primates are important for preclinical vaccine evaluation. In depth characterization of the antibody response requires representative immunoglobulin (IG) germline gene databases for correct gene and allele assignments and assessme...
Evolution of SAMD9 and SAMD9L genes in primates: a complex history of gene loss, gene duplication and pseudogenization [0.03%]
灵长类动物SAMD9和SAMD9L基因的进化：基因丢失、基因复制及假基因化的复杂历史
António Duarte,Ana Pinheiro,Pedro José Esteves
António Duarte
Compact genomic architecture of the axolotl MHC region: setting the record straight [0.03%]
.axl基因组MHC区的精简结构：正本清源
Magdalena Migalska,Krzysztof Fluder,Katarzyna Dudek et al.
Magdalena Migalska et al.
The Major Histocompatibility Complex (MHC) is a gene-dense genomic region essential to adaptive immunity, exhibiting both conserved features and lineage-specific rearrangements across jawed vertebrates. Amphibians, as basal tetrapods, offer...
Evaluation of lymphoid defects in specific inborn errors of immunity using a single-tube multicolor flow cytometry assay [0.03%]
应用多重流式细胞检测法评估先天性免疫缺陷病的淋巴细胞缺陷
Reja Tanveer,Sanchi Chawla,Saniya Sharma et al.
Reja Tanveer et al.
The present study aimed to evaluate lymphoid defects in patients with specific IEIs (n = 28) using a 12-antibody 9-color single-tube flow cytometry assay. The lymphoid defects (lymphocyte counts below the reference range) were significantly...
Genetic insights into the major histocompatibility complex class I BF2 gene of Korean native chickens in relation to the LEI0258 microsatellite marker and the 90-SNP panel [0.03%]
与LEI0258微卫星标记和90-SNP基因分型面板有关的韩国地方鸡MHC-I类BF2基因遗传研究
Trisha Nicole Agulto,Minjun Kim,Prabuddha Manjula et al.
Trisha Nicole Agulto et al.
The chicken major histocompatibility complex (MHC) represents a "minimal essential MHC" consisting of classical class I (BF) and class II (BL) molecules that present peptides to CD8+ cytotoxic and CD4+ helper T cells, respectively. Class I ...
Immunoglobulin genetics of a model squamate reptile, Tiliqua rugosa [0.03%]
沙蜥蜴(Tiliqua rugosa)的免疫球蛋白遗传学特性研究
Jordan M Sampson,Kieran J Mikolajova,Michael G Gardner et al.
Jordan M Sampson et al.
Squamate reptiles are a diverse group of terrestrial vertebrates that includes over 10,000 species. Despite their broad distribution, they are relatively understudied immunologically. Fortunately, recent advances in comparative genomics hav...
Association between single-nucleotide polymorphism rs868875 of CLEC4M gene and clinical severity of COVID-19 in a Brazilian population [0.03%]
巴西人群中CLEC4M基因单核苷酸多态性rs868875与新冠肺炎临床严重程度相关性的研究
Steffany Larissa Galdino Galisa,Marcus Villander Barros de Oliveira Sá,Natália Machado Tavares et al.
Steffany Larissa Galdino Galisa et al.
COVID-19, caused by the SARS-CoV-2 virus, has had a global impact, leading to high incidence and mortality rates worldwide. Host genetics significantly influence individual susceptibility to severe COVID-19. The C-type lectin domain family ...