Effectiveness of Radiotherapy in Preventing Heterotopic Ossification: A Meta-analysis of Randomized Controlled Trials Beyond Total Hip Arthroplasty [0.03%]
放射治疗预防异位骨化的疗效Meta分析（全髋关节置换以外的系统性疾病及创伤）
Lei Wen,Ge Chen,Changshun Chen et al.
Lei Wen et al.
Heterotopic ossification (HO) frequently occurs after procedures such as hip replacements, acetabular fractures, and elbow fractures. While radiotherapy (RT) has been a longstanding preventive measure against HO, its efficacy remains contro...
Effect of Oral Semaglutide on Volumetric BMD and Bone Microarchitecture in Overweight/Obese Individuals with Type 2 Diabetes [0.03%]
利拉鲁肽对超重或肥胖的2型糖尿病患者骨骼体积骨密度和骨微结构的影响
Liza Das,Sanjay Kumar Bhadada,Durairaj Arjunan et al.
Liza Das et al.
Obesity, type 2 diabetes, and therapeutic weight loss are all associated with impaired bone quantity and microarchitecture. Glucagon-like peptide receptor analogs (GLP1RAs) have direct beneficial effects on bone microarchitecture, in precli...
Expanding the Genotypic and Phenotypic Spectrum of P3H1 Related Osteogenesis Imperfecta [0.03%]
P3H1基因相关的成骨不全症的表型和基因型谱系的研究
Erdem Kındış,Enise Avcı Durmuşaliğlu,Elif Eviz
Erdem Kındış
Osteogenesis Imperfecta (OI) is a genetically heterogeneous disorder with a clinical spectrum ranging from mild to severe. Biallelic P3H1 (OMIM*610339) variants are generally associated with a severe recessive phenotype. This study reports ...
Impacts of Nonenzymatic Glycation Crosslinks in Bone Matrix on the Mechanosensitivity of Osteocyte [0.03%]
骨基质非酶糖化交联对骨细胞力学敏感性的影响
Cong-Jin Liu,Xiao Yang,Jing-Wen Shi et al.
Cong-Jin Liu et al.
The products of nonenzymatic glycation (NEG) are a key contributor to various types of osteoporosis, as they affect both the physical properties of bone matrix and the function of osteoblasts and osteoclasts. However, their impact on the me...
Yuehua Li,Lei Zheng,Wenjie Cheng et al.
Yuehua Li et al.
Heparan sulfate (HS) is synthesized in majority of cells in the human body and is typically released as an extension of polysaccharide chains, which then covalently bind to the protein core of proteoglycans to form heparan sulfate proteogly...
Bone Mineral Density During Treatment with The Janus Kinase Inhibitor Baricitinib in Patients with Rheumatoid Arthritis: A Monocentric Observational Study [0.03%]
一项单中心观察性研究：托法替布治疗类风湿关节炎患者期间的骨矿密度变化
Nils Schulz,Thomas Asendorf,Pascal van Wijnen et al.
Nils Schulz et al.
Rheumatoid arthritis (RA) is associated with systemic bone loss and thus an established risk factor for osteoporosis. Janus kinase inhibitors (JAKi) have shown osteo-protective effects. However, clinical data on the effects of baricitinib o...
Observational Study
Calcified tissue international. 2025 Jul 22;116(1):101. DOI:10.1007/s00223-025-01410-9 2025
Identification of a Novel Gene ARNT2 for Osteogenic Differentiation of Mesenchymal Stem Cells [0.03%]
鉴定出一种新的基因ARNT2可诱导间充质干细胞向成骨细胞方向分化
Mina Ding,Zhiwei Hu,Ke Pei et al.
Mina Ding et al.
The balance between adipogenesis and osteogenesis in mesenchymal stem cells (MSCs) is pivotal for the maintenance of bone homeostasis. However, the genes responsible for regulating this balance are still not fully understood. This investiga...
Effect of A Patient Reminder Program on Adherence in Postmenopausal Women with Osteoporosis Receiving Oral Bisphosphonate Treatment: A Randomized Clinical Control Trial [0.03%]
面向绝经后女性骨质疏松患者服用口服双磷酸盐的依从性提升方案：一项随机临床对照试验
U Stumpf,I Kyvernitakis,K Horas et al.
U Stumpf et al.
Poor adherence to oral bisphosphonate therapy remains a major challenge in the treatment of osteoporosis, substantially reducing therapeutic efficacy. While reminder interventions have been proposed as a method to enhance adherence, evidenc...
Randomized Controlled Trial
Calcified tissue international. 2025 Jul 16;116(1):99. DOI:10.1007/s00223-025-01405-6 2025
Blockade of Gi Signaling Enhances the Anabolic Effect of Parathyroid Hormone in Female Mice [0.03%]
G蛋白偶联抑制增强甲状旁腺素的促合成作用
Liping Wang,Lalita Wattanachanya,Vikrant Piprode et al.
Liping Wang et al.
Intermittent administration of parathyroid hormone (PTH) produces potent anabolic effects on bone. These anabolic effects appear to be mediated by activation of the Gs-cyclic AMP system initiated by the PTH1 receptor (PTHR1) in osteoblast l...
Correction to: Type 2 Diabetes Mellitus is Associated with Increased Risk of Sarcopenia: A Systematic Review and Meta-Analysis [0.03%]
对报道:2型糖尿病与肌少症风险增加相关性的系统评价和meta分析的更正通知
Panagiotis Anagnostis,Nifon K Gkekas,Charoula Achilla et al.
Panagiotis Anagnostis et al.
Published Erratum
Calcified tissue international. 2025 Jul 14;116(1):97. DOI:10.1007/s00223-025-01408-3 2025