Spatial Regulation of Preameloblast Development in Response to Distal Mouse Incisor Injury [0.03%]
响应小鼠前牙远端损伤的成牙本质细胞发育的空间调节
Alexia Campbell,Kevin Lin,Jake Ngu et al.
Alexia Campbell et al.
Enamel, the outermost mineralized tissue of the tooth, is produced by specialized dental epithelial cells called ameloblasts. Unlike human enamel, which lacks regenerative capacity, the mouse incisor grows throughout life, driven by adult s...
Lauter E Pelepenko,Joaquim Barreto,Marília P Martins et al.
Lauter E Pelepenko et al.
The effects of gliflozins on bones of CKD patients on dialysis are unknown. Recently, SGLT2 expression in bone tissue of patients with CKD has been reported. We hypothesized that dapagliflozin may act in bone cells and modulate the Klotho-F...
Randomized Controlled Trial
Calcified tissue international. 2026 Aug 14;117(1):130. DOI:10.1007/s00223-026-01587-7 2026
The Association Between Type 2 Diabetes and Bone Microarchitecture Assessed by HR-pQCT [0.03%]
HR-pQCT评估的2型糖尿病与骨微结构之间的关系
Alexandre Mercier-Guery,Blandine Merle,Maxime Auroux et al.
Alexandre Mercier-Guery et al.
Type 2 diabetic patients generally have higher BMD but greater fracture risk. Exploring their bone microarchitecture might help to explain their bone fragility. We conducted a cross-sectional matched analysis within three prospective cohort...
The Association Between Type 2 Diabetes and Bone Microarchitecture Assessed by HR-pQCT [0.03%]
HR-pQCT评估的2型糖尿病与骨微结构之间的关系
Alexandre Mercier-Guery,Blandine Merle,Maxime Auroux et al.
Alexandre Mercier-Guery et al.
Type 2 diabetic patients generally have higher BMD but greater fracture risk. Exploring their bone microarchitecture might help to explain their bone fragility. We conducted a cross-sectional matched analysis within three prospective cohort...
Burden of Disease in Pediatric Tumor-Induced Osteomalacia: A Literature Review [0.03%]
肿瘤诱导性骨软化症的疾病负担：文献综述
Salvatore Minisola,Suzanne M Jan de Beur,Thomas O Carpenter et al.
Salvatore Minisola et al.
Tumor-induced osteomalacia (TIO) is an ultra-rare, paraneoplastic syndrome caused by tumors secreting fibroblast growth factor 23 (FGF23). In children, TIO may be mistaken for more common causes of rickets and osteomalacia, including monoge...
Optimal Resistance Exercise Strategies for Improving Bone Mineral Density in Middle-Aged and Older Adults: A Network Meta-Analysis Based on Exercise Intensity and Frequency [0.03%]
基于运动强度和频率的网络 meta 分析：制定优化的抗阻运动策略，提高中老年人骨矿密度
Wenhua Zhang,Jingqi Mei,Xun Li et al.
Wenhua Zhang et al.
This study used a network meta-analysis to evaluate the effects of different resistance training intensities and frequencies on bone mineral density (BMD) in middle-aged and older adults, aiming to identify the optimal exercise strategy for...
Multifactorial Regulation of Inflammatory Bone Loss in Chronic Inflammatory and Immune-Associated Disorders: Osteoimmune Mechanisms and Translational Prospects of Natural Small Molecules [0.03%]
慢性炎症和免疫相关疾病中炎性骨丢失的多因素调节：成骨免疫机制及天然小分子转化应用前景
Juhao Pi,Bolei Li,Qiangzhong Pi et al.
Juhao Pi et al.
Inflammatory bone loss is a frequent complication of chronic inflammatory and immune-associated disorders. In this review, we synthesize the osteoimmune mechanisms through which persistent inflammation disrupts coupled bone remodeling, with...
Strontium Treatment Potentiates Bone Anabolic Action of Intermittent PTH in Ovariectomized Rats [0.03%]
间歇PTH治疗中补充锶可增强去卵巢大鼠骨形成作用
Cyril Thouverey,Isabelle Badoud,Patrick Ammann
Cyril Thouverey
To optimize osteoporosis therapy with the parathyroid hormone fragment teriparatide (PTH1-34), we sought to determine whether strontium (Sr) could potentiate the bone anabolic action of intermittent PTH1-34 in ovariectomized rats. Female ra...
Piezo1, Integrins, and YAP/TAZ in Osteoporotic Mechanotransduction: Key Pathways, Crosstalk, and Therapeutic Implications [0.03%]
骨质疏松力学信号转导中的Piezo1、整合素和YAP/TAZ：关键通路、相互作用及治疗意义
Yaxiong Gao,Tiansheng Bu
Yaxiong Gao
Osteoporosis is a systemic skeletal disorder fundamentally characterized by an imbalance between bone formation and bone resorption, ultimately leading to reduced bone mass, microarchitectural deterioration, and increased fracture susceptib...
Differential Effects of a First-in-Class IKKα Inhibitor on Trabecular and Cortical Bone in a Human Prostate Cancer Xenograft Model [0.03%]
第一类IKKα抑制剂对人前列腺癌异种移植模型中 trabecular和cortical骨的差异效应
Abdullah Al-Jeffery,Feier Zeng,Antonia Sophocleous et al.
Abdullah Al-Jeffery et al.
IKKα, a key component of canonical and non-canonical NFκB signalling, is implicated in prostate cancer and bone metabolism. Here, we validated the anti-proliferative effects of selected molecules from a series of first-in-class IKKα inhi...