Circulating α-Klotho and Multidimensional Aging and Frailty Outcomes: A Systematic Review and Meta-Analysis from the European Renal Association CKD-MBD Working Group [0.03%]
Mustafa Guldan,Lasin Ozbek,Derya G Fidan et al.
Mustafa Guldan et al.
Although α-Klotho has gained attention as a promising biomarker of aging, its association with frailty and broader aging-related outcomes beyond chronic kidney disease-mineral and bone disorder remains incompletely characterized. This syst...
Impaired Remodeling of Tight Junctions Associated with Loss of Enamel Rod Decussation in Tgfbr2G357W/+ Mice [0.03%]
Olivier Duverger,Valentina Baena,Zulfeqhar A Syed et al.
Olivier Duverger et al.
During enamel secretion, ameloblasts follow a complex coordinated movement that results in the enamel rods being arranged in a crisscross pattern that contributes significantly to its exceptional mechanical properties. We previously determi...
Zuping Wu,Hengyuan Liu,Ruifeng Song et al.
Zuping Wu et al.
Brent Vasquez,Ai Thu Bui,Henry C Margolis et al.
Brent Vasquez et al.
Yiting Li,Jiahui Zheng,Sihan Yu et al.
Yiting Li et al.
WDR72 Regulates Microtubule-Associated Vesicular miRNA Export in Ameloblasts During Enamel Maturation [0.03%]
Trang Duong,Jake Ngu,Kaitlin A Katsura et al.
Trang Duong et al.
Enamel maturation depends on the ability of ameloblasts to undergo repeated cycles of morphological remodeling, a process known as ameloblast modulation. These transitions require precise coordination between cytoskeletal reorganization and...
Guilherme H Souza Bomfim,Anna Zou,Fabio A Echeverry et al.
Guilherme H Souza Bomfim et al.
Ameloblasts are specialized epithelial cells that form enamel during the secretory and maturation stages, the latter involving an increase in Ca2+ transport to mineralize the enamel crystals. During enamel formation, ameloblasts travel seve...
Ano1 Antisense Therapy Improves Enamel Properties in Molars but not Amelogenesis in a Murine Model of Cystic Fibrosis [0.03%]
Dinne Nedjar,Arnaud Vanden Bossche,Christie Mitri et al.
Dinne Nedjar et al.
Cystic fibrosis (CF) is a life-shortening inherited disorder caused by mutations in the gene encoding the Cystic Fibrosis Transmembrane conductance Regulator (CFTR), a protein that controls the transport of chloride ions across cell membran...
Sex-Specific Associations of Radiographic Knee Osteoarthritis and Pain with Distal Tibia Bone Microarchitecture: the Study of Muscle, Mobility and Aging (SOMMA) [0.03%]
Tong Yu,Andy Kin On Wong,Nina Z Heilmann et al.
Tong Yu et al.
Knee osteoarthritis (OA) is the most common joint disease and despite being associated with higher areal bone mineral density (aBMD), increases fracture risk. This paradox suggests that in addition to mobility and fall concerns, microarchit...
Clinical and Genetic Characterization of Osteogenesis Imperfecta in Japanese Patients: Outcomes of Sequential Bisphosphonate Therapy [0.03%]
Chieko Yamada,Takuo Kubota,Hirofumi Nakayama et al.
Chieko Yamada et al.
Although novel drug development and clinical trials are ongoing, bisphosphonates remain the standard treatment of osteogenesis imperfecta (OI). This study aimed to evaluate clinical effects of bisphosphonate therapy across clinical subtypes...