Bone Mineral Density During Treatment with The Janus Kinase Inhibitor Baricitinib in Patients with Rheumatoid Arthritis: A Monocentric Observational Study [0.03%]
一项单中心观察性研究：托法替布治疗类风湿关节炎患者期间的骨矿密度变化
Nils Schulz,Thomas Asendorf,Pascal van Wijnen et al.
Nils Schulz et al.
Rheumatoid arthritis (RA) is associated with systemic bone loss and thus an established risk factor for osteoporosis. Janus kinase inhibitors (JAKi) have shown osteo-protective effects. However, clinical data on the effects of baricitinib o...
Observational Study
Calcified tissue international. 2025 Jul 22;116(1):101. DOI:10.1007/s00223-025-01410-9 2025
Identification of a Novel Gene ARNT2 for Osteogenic Differentiation of Mesenchymal Stem Cells [0.03%]
鉴定出一种新的基因ARNT2可诱导间充质干细胞向成骨细胞方向分化
Mina Ding,Zhiwei Hu,Ke Pei et al.
Mina Ding et al.
The balance between adipogenesis and osteogenesis in mesenchymal stem cells (MSCs) is pivotal for the maintenance of bone homeostasis. However, the genes responsible for regulating this balance are still not fully understood. This investiga...
Effect of A Patient Reminder Program on Adherence in Postmenopausal Women with Osteoporosis Receiving Oral Bisphosphonate Treatment: A Randomized Clinical Control Trial [0.03%]
面向绝经后女性骨质疏松患者服用口服双磷酸盐的依从性提升方案：一项随机临床对照试验
U Stumpf,I Kyvernitakis,K Horas et al.
U Stumpf et al.
Poor adherence to oral bisphosphonate therapy remains a major challenge in the treatment of osteoporosis, substantially reducing therapeutic efficacy. While reminder interventions have been proposed as a method to enhance adherence, evidenc...
Randomized Controlled Trial
Calcified tissue international. 2025 Jul 16;116(1):99. DOI:10.1007/s00223-025-01405-6 2025
Blockade of Gi Signaling Enhances the Anabolic Effect of Parathyroid Hormone in Female Mice [0.03%]
G蛋白偶联抑制增强甲状旁腺素的促合成作用
Liping Wang,Lalita Wattanachanya,Vikrant Piprode et al.
Liping Wang et al.
Intermittent administration of parathyroid hormone (PTH) produces potent anabolic effects on bone. These anabolic effects appear to be mediated by activation of the Gs-cyclic AMP system initiated by the PTH1 receptor (PTHR1) in osteoblast l...
Correction to: Type 2 Diabetes Mellitus is Associated with Increased Risk of Sarcopenia: A Systematic Review and Meta-Analysis [0.03%]
对报道:2型糖尿病与肌少症风险增加相关性的系统评价和meta分析的更正通知
Panagiotis Anagnostis,Nifon K Gkekas,Charoula Achilla et al.
Panagiotis Anagnostis et al.
Published Erratum
Calcified tissue international. 2025 Jul 14;116(1):97. DOI:10.1007/s00223-025-01408-3 2025
Decreased Expression and Secretion of the Myokine Fndc5/Irisin by Cisplatin Treatment in Mouse Skeletal Muscle [0.03%]
顺铂处理小鼠骨骼肌中myokine Fndc5/Irisin的表达和分泌减少
Yu Miyauchi,Shinki Soga,Hayato Nanri et al.
Yu Miyauchi et al.
The systemic administration of cisplatin has been shown to substantially reduce skeletal muscle mass. This is a serious concern, as muscle loss is correlated with increased mortality in patients with cancer. Cisplatin also contributes to co...
CD8a + GZMK + T Cells Inhibit Osteoclastogenesis in Postmenopausal Osteoporosis via the p38-MAPK Pathway [0.03%]
CD8a+GZMK+T细胞通过p38-MAPK途径抑制绝经后骨质疏松患者的破骨细胞生成
Xuecheng He,Jiajun Wang,Mengxue Liu et al.
Xuecheng He et al.
This study aims to investigate the heterogeneity and function of bone marrow T cells in postmenopausal osteoporosis (PMOP). Single-cell transcriptome sequencing was employed to cluster T cells from the femoral bone marrow of mice with PMOP....
The Influence of Different Degrees of Energy Restriction on Bone Parameters in Young Female Rats [0.03%]
不同程度限能对青年雌鼠骨参数的影响
Yuki Aikawa,Yusuke Wakasugi,Kazuki Kioka et al.
Yuki Aikawa et al.
The present study aimed to determine the influence of different degrees of energy restriction (ER) on the bones in young female rats. Forty female Sprague-Dawley rats (n = 40; age, 6 weeks) were randomly divided into the following five expe...
Examination of Skeletal and Senescence Phenotypes in Young Mice with Juvenile Onset Type 1 Diabetes [0.03%]
青年发病1型糖尿病小鼠骨骼和衰老表型的检测
Japneet Kaur,Hannah W Brooks,Mitchell N Froemming et al.
Japneet Kaur et al.
Type 1 diabetes (T1D) and T2D are associated with skeletal fragility, contributing to increased fracture risk. Whereas decreased bone mineral density (BMD) is common in T1D, individuals with T2D tend to have normal or elevated BMD. These di...
Feasibility of 100 kV Low-voltage Bone Mineral Density Measurement with Quantitative CT: Phantom and Clinical Research [0.03%]
基于低能CT的骨密度定量评估的可行性研究
Yali Li,Dan Jin,Yan Zhang et al.
Yali Li et al.
To investigate the feasibility and accuracy of 100 kV low-voltage quantitative CT (QCT) for bone mineral density (BMD) measurement using the European Spine Phantom and patients. The accuracy and precision of the BMD measurements were assess...