Probing tau citrullination in Alzheimer's disease brains and mouse models of tauopathy [0.03%]
探明Tau瓜氨酸化在阿尔茨海默病中的作用及tau病理小鼠模型研究
Huimin Liang,Jerry B Hunt Jr,Chao Ma et al.
Huimin Liang et al.
Alzheimer's disease (AD) includes a defining hallmark that correlates most closely to cognitive decline, namely misfolded tau protein. However, the "upstream" etiology and downstream clinical manifestations of tauopathies are quite diverse....
Nucleolar aggregation of key neuropathological proteins in the postmortem neurodegenerative brain [0.03%]
神经退行性大脑中核糖体聚集关键神经病理蛋白
Guinevere F Lourenco,Maria Elizabeth Torres-Pacheco,YuHong Fu et al.
Guinevere F Lourenco et al.
Nucleolar disturbances have long been implicated in neurodegenerative diseases but, to date, aggregation and immobilization of proteins into nucleolar bodies have only been reported in vitro and in cell models, and only for amyloid β (Aβ)...
Genetic factors and comorbid pathologies interact to drive regional mitophagy alterations in Lewy body dementia [0.03%]
遗传因素和共病病理相互作用驱动路易体痴呆的区域线粒体自噬改变
Xu Hou,Tyrique Richardson,Michael G Heckman et al.
Xu Hou et al.
The kinase-ligase pair PINK1-PRKN initiates mitophagy by recognizing and selectively tagging worn-out and dysfunctional mitochondria with phosphorylated ubiquitin (pS65-Ub) to facilitate their elimination via autophagy. In human autopsy bra...
Manuela Neumann,Marleen Van den Broeck,Sarah Wynants et al.
Manuela Neumann et al.
Loss of global DNA hypermethylation is prognostic in IDH-mutant and 1p/19q-codeleted oligodendrogliomas [0.03%]
异柠檬酸脱氢酶突变和1p/19q杂合缺失胶质瘤中全球DNA去高甲基化具有预后价值
Felix E Hinz,Dennis Friedel,Franziska M Ippen et al.
Felix E Hinz et al.
Neuropathologic correlates of cognitive impairment in Alzheimer's disease with discordant CSF biomarker profiles: co-pathologies in focus [0.03%]
阿尔茨海默病患者认知障碍的神经病理与不一致的脑脊液生物标志物谱系：以共病变为焦点
Konstantinos Ioannou,Richard J Perrin,Khadidzha Abdullaieva et al.
Konstantinos Ioannou et al.
CSF Aβ reflects Alzheimer's disease neuropathologic change (ADNC), while CSF p-tau offers an indirect indication of tangle pathology. However, interpretation can be challenging when cognitive impairment is present alongside Aβ positivity ...
Alicia Fürst,Viktoria Ruf,Christian Fiedler et al.
Alicia Fürst et al.
Genetic variation in TMEM106B alters microglial activation and cytokine responses in chronic traumatic encephalopathy [0.03%]
TMEM106B基因变异通过改变慢性创伤性脑病中的小胶质细胞活化和细胞因子反应影响疾病进程
Shahar Hartman,Nurgul Aytan,Raymond Nicks et al.
Shahar Hartman et al.
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease caused by repetitive head impacts (RHI). However, individuals with similar RHI exposure can show differing pathology, suggesting a role for genetic variation. A common Tr...
Rare IDH hotspot mutations in dysembryoplastic neuroepithelial tumors expand the spectrum of IDH-altered CNS tumors [0.03%]
染色体畸形神经上皮瘤中罕见的IDH热点突变扩展了IDH改变型CNS肿瘤的范围
Martin Raby,Euphrasie Servant,Volodia Dangouloff-Ros et al.
Martin Raby et al.
Expanding the spectrum of annexin A11 proteinopathy in frontotemporal lobar degeneration and motor neuron disease [0.03%]
胶质噬性神经蛋白病中 annexin A11 蛋白病变的谱系扩大
Nikhil B Ghayal,Richard J Crook,Angita Jain et al.
Nikhil B Ghayal et al.
Aggregation of TAR-DNA-binding protein 43 (TDP-43) is strongly associated with frontotemporal lobar degeneration (FTLD-TDP), motor neuron disease (MND-TDP), and overlap disorders like FTLD-MND. Three major forms of motor neuron disease are ...