Genetic factors and comorbid pathologies interact to drive regional mitophagy alterations in Lewy body dementia
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The kinase-ligase pair PINK1-PRKN initiates mitophagy by recognizing and selectively tagging worn-out and dysfunctional mitochondria with phosphorylated ubiquitin (pS65-Ub) to facilitate their elimination via autophagy. In human autopsy brains, the number of p... ...
