FAP expression as a marker of malignant transformation enabling in vivo characterization in peripheral nerve sheath tumors: a multimodal and translational study [0.03%]
FAP表达作为恶性转化标志在周围神经鞘肿瘤活体表征的多模态及转化研究
Nic G Reitsam,Alexander Gäble,Lisa Siebenhüter et al.
Nic G Reitsam et al.
Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas and a major cause of mortality in neurofibromatosis type 1 (NF-1). Distinguishing MPNSTs from benign neurofibromas remains challenging. We investigated fibroblast act...
Yunjung Jin,Kai Chen,Alexander Q Wixom et al.
Yunjung Jin et al.
Lewy body dementia (LBD), encompassing dementia with Lewy bodies and Parkinson's disease dementia, is neuropathologically defined by neuronal accumulation of α-synuclein encoded by the SNCA gene. Genetic risk factors strongly influence LBD...
α-synuclein triggers NCOA4-FTH1-mediated ferroptosis of oligodendrocyte in multiple system atrophy [0.03%]
α-突触核蛋白触发NCOA4-FTH1介导的小脑桥脑红核维生素样萎缩少突胶质细胞铁死亡
Zhenwei Yu,Ehsan Arkin,Yang Li et al.
Zhenwei Yu et al.
Multiple system atrophy (MSA) is a fatal neurodegenerative synucleinopathy characterized by the accumulation of α-synuclein in oligodendrocytes, forming glial cytoplasmic inclusions. Although iron dysregulation and ferroptosis, an iron-dep...
Pathological insights into cerebral amyloid angiopathy underlying intracerebral haemorrhage: population-based autopsy study [0.03%]
基于尸体解剖的流行病学研究揭示脑淀粉样血管病引起脑出血的病理特征
Ya Su,Mark A Rodrigues,Neshika Samarasekera et al.
Ya Su et al.
Lobar intracerebral haemorrhage (ICH) is associated with cerebral amyloid angiopathy (CAA) pathology. Uncertainty remains about the mechanisms leading from CAA to ICH. We investigated the distribution and characteristics of CAA, and its cli...
Early synaptic pathology is associated with small tau aggregates in Alzheimer's disease [0.03%]
阿尔茨海默病早期突触损伤与小tau蛋白聚集体有关
Emre Fertan,Shekhar Kedia,George Nolan et al.
Emre Fertan et al.
Alzheimer's disease (AD) is phenotypically characterised by progressive memory loss, which has been linked to tau aggregation and synaptic dysfunction. Here we characterised the nanoscopic tau aggregates in individual synaptosomes from AD c...
Germline variants in ATM, BRCA2, other cancer predisposition and novel candidate genes are implicated in glioma risk in adult glioma patients with a familial or personal history of tumors [0.03%]
ATM、BRCA2及其他癌症易感和新的候选基因的种系变异与具有家族或个人肿瘤史的成人胶质瘤患者的发病风险相关
Frank Brand,Lily S Rose,Amir H Akbarzadeh et al.
Frank Brand et al.
Familial occurrence of gliomas has been reported in around 5% of patients. Studies on the genetic landscape of glioma predisposition are scarce. Here, leukocyte DNA of 213 adult glioma patients with a familial and/or personal tumor history ...
Genetic Creutzfeldt-Jakob disease linked to the E200K mutation: a large cohort study [0.03%]
与E200K突变相关的遗传性克雅氏病的队列研究
Brian S Appleby,Matteo Manca,Megan S Piazza et al.
Brian S Appleby et al.
Creutzfeldt-Jakob disease (CJD), the most common human prion disease, is an invariably fatal neurodegenerative disorder affecting 1.5 cases per million individuals per year. About 10-15% of the human prion diseases are caused by a pathogeni...
Comparative study of the pathology in anterior versus posterior hemispheric regions of cerebellum in essential tremor and controls [0.03%]
小脑前叶和后叶原发性震颤病理改变与对照的比较研究
Jessica B Musacchio-Perrucci,Regina T Martuscello,Sophia I Betzios et al.
Jessica B Musacchio-Perrucci et al.
Essential tremor (ET), among the most common movement disorders, is characterized by 8-12 Hz action tremor of the upper extremities. Cognitive dysfunction is increasingly recognized. Postmortem studies of anterior cerebellar cortex, which p...
Comparative Study
Acta neuropathologica. 2026 Jan 12;151(1):4. DOI:10.1007/s00401-025-02974-4 2026
Biochemical signatures of skin α-synuclein in synucleinopathies revealed by RT-QuIC assay end-product analysis [0.03%]
RT-QuIC终点产物分析揭示的人类皮肤α-突触核蛋白的生化标志物
Maria Gerasimenko,Hancun Yi,Tricia Gilliland et al.
Maria Gerasimenko et al.
Synucleinopathies, including Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA), share pathological accumulation of misfolded α-synuclein (αSyn) in the brain and overlapping clinical features, com...
Vasculitic fasciitis characterizes a distinct subset of vasculitic myopathy with interferon-gamma signature [0.03%]
血管性皮炎特征是一种具有干扰素-γ谱型的血管性肌病亚型
Nikolas Ruffer,Iago Pinal-Fernandez,Corinna Preusse et al.
Nikolas Ruffer et al.
Vasculitic myopathy (VM) represents a nonspecific manifestation of various vasculitic syndromes that presents with myalgia, leg tenderness, and muscle weakness. Most cases of VM develop in the context of polyarteritis nodosa (PAN), antineut...