Neuropathological study of the effects of aducanumab anti-Aβ immunotherapy on patients with Alzheimer's disease [0.03%]
关于抗Aβ免疫疗法阿杜卡努单抗对阿尔茨海默病患者神经病理影响的研究
Lindsay A Welikovitch,Derek H Oakley,Rachel E Bennett et al.
Lindsay A Welikovitch et al.
Fluid and imaging biomarker data show that anti-amyloid (Aβ) antibodies promote the clearance of Aβ from the brains of patients with Alzheimer's disease (AD). We examined postmortem brain tissue of individuals who participated in aducanum...
Mechanisms of increased Alzheimer's disease pathology with R47H and R62H TREM2 variants [0.03%]
R47H和R62H TREM2变异体增加阿尔茨海默病病理变化的机制
Nurun N Fancy,Nanet Willumsen,Vicky M N Chau et al.
Nurun N Fancy et al.
TREM2 plays multiple functional roles in microglia and variants are associated with increased risks of Alzheimer's disease (AD). Genetic polymorphisms reducing expression of the functionally related protein CD33 are protective. Here we have...
Expression of GPR34 in microglia remains stable in human Alzheimer's disease [0.03%]
人阿尔茨海默病中微胶质细胞中的GPR34表达稳定
Sophie Seiffer,Jonas Rotter,Jana Brendler et al.
Sophie Seiffer et al.
Microglia are the resident immune cells of the human central nervous system and play key roles in development, homeostasis, and disease. These functions are mediated by a broad repertoire of cell-surface receptors, including G protein-coupl...
AETA peptide contributes to Alzheimer's disease signature of synapse dysfunction [0.03%]
AETA肽贡献于阿尔茨海默病的突触功能障碍特征
Jade Dunot,Carine Gandin,Marin Truchi et al.
Jade Dunot et al.
Alzheimer's disease (AD), the leading cause of dementia, is characterized by early synaptic dysfunction that precedes overt cognitive decline. While amyloid-β and Tau remain central to AD pathogenesis, molecular triggers of synapse weakeni...
GRP78 associates with alpha-synuclein in vulnerable neurons of the Parkinson's disease brain [0.03%]
格兰氏蛋白78与帕金森病易感神经细胞中的α-突触核蛋白相互作用
Dominik Hrabos,Anna Mrowiecova,Jitka Cicmancova et al.
Dominik Hrabos et al.
Reevaluating the role of beta2-microglobulin: new insights on selective vulnerability in ALS pathology [0.03%]
β2微球蛋白在ALS病理选择性易感性中的作用及其新见解
Melanie Leboeuf,Jik Nijssen,Laura Helen Comley et al.
Melanie Leboeuf et al.
Amyotrophic lateral sclerosis (ALS) is characterized by the selective loss of motor neurons (MNs). Why these neurons are particularly vulnerable in ALS remains unclear, as does why certain MN groups remain resistant throughout the disease c...
TANC1::HTRA1 and KPNA4::WWTR1 fusions in non-vestibular intracranial schwannomas [0.03%]
非前庭颅内施万瘤中的TANC1::HTRA1和KPNA4::WWTR1融合基因
Takahiro Tsuchiya,Satoru Miyawaki,Yudai Hirano et al.
Takahiro Tsuchiya et al.
Neocortical tau burden determines the degree of cognitive impairment in individuals with Braak stage V neurofibrillary degeneration [0.03%]
新皮层tau负荷决定Braak五期神经原纤维缠结变性个体认知障碍的程度
Timothy E Richardson,Jonathan Cherry,Shrishtee Kandoi et al.
Timothy E Richardson et al.
Alzheimer disease neuropathologic change (ADNC) is considered to be the most common cause of cognitive decline and dementia worldwide. ADNC level is determined using the density of neuritic plaques in combination with the topographical dist...
Alpana Singh,Marisa N Denkinger,Antoine Leuzy et al.
Alpana Singh et al.
Cerebral amyloid angiopathy (CAA) is a cerebrovascular disorder characterized by the deposition of amyloid-β (Aβ) in the walls of leptomeningeal and cortical blood vessels that increases risk of intracerebral hemorrhages and progressive c...
The phosphoproteomic landscape of the neurological manifestations in tuberous sclerosis complex [0.03%]
结节性硬化症神经表现的磷酸化蛋白质组景观
Marie Girodengo,Simeon R Mihaylov,Katarzyna Klonowska et al.
Marie Girodengo et al.
Tuberous sclerosis complex (TSC) is a rare disease caused by mutations in TSC1 and TSC2, resulting in activation of mechanistic target of rapamycin complex 1 (mTORC1). Neurological manifestations in TSC patients include epilepsy, autism and...