Cerebrospinal fluid cell-free DNA sequencing in pediatric CNS tumors: towards liquid molecular neuropathology [0.03%]
儿童中枢神经系统肿瘤的脑脊液游离DNA测序：迈向液体分子神经病理学
William Gehin,Marie-Sophie Merlin,Alexandre Harle et al.
William Gehin et al.
Pediatric central nervous system tumors remain a leading cause of cancer-related mortality in children, while their diagnosis, risk stratification, and therapeutic management increasingly depend on integrated molecular characterization. How...
Cerebrospinal fluid cell-free DNA sequencing in pediatric CNS tumors: towards liquid molecular neuropathology [0.03%]
儿童中枢神经系统肿瘤的脑脊液无细胞DNA测序：迈向液体分子神经病理学
William Gehin,Marie-Sophie Merlin,Alexandre Harle et al.
William Gehin et al.
Pediatric central nervous system tumors remain a leading cause of cancer-related mortality in children, while their diagnosis, risk stratification, and therapeutic management increasingly depend on integrated molecular characterization. How...
Activated microglial phenotypes in the hippocampal CA2 subfield are implicated in Lewy body disease progression [0.03%]
活化的小胶质细胞表型与路易小体疾病的海马CA2亚区病变有关
Esteban Luna,Katheryn A Q Cousins,Sheina Emrani et al.
Esteban Luna et al.
Histopathologic staging models of neuronal α-synuclein pathology (n-asyn) in Lewy body disease (LBD) seldom evaluate brain regions with direct synaptic connectivity to model the role of microglial processes. We address this gap by testing ...
Activated microglial phenotypes in the hippocampal CA2 subfield are implicated in Lewy body disease progression [0.03%]
活化的小胶质细胞表型与路易小体疾病的海马CA2亚区病变有关
Esteban Luna,Katheryn A Q Cousins,Sheina Emrani et al.
Esteban Luna et al.
Histopathologic staging models of neuronal α-synuclein pathology (n-asyn) in Lewy body disease (LBD) seldom evaluate brain regions with direct synaptic connectivity to model the role of microglial processes. We address this gap by testing ...
Microglial 5-LOX-activating protein antagonism alleviates leukotriene-driven neuroinflammation [0.03%]
微胶质细胞5-LOX活化蛋白抗原拮抗缓解白三烯驱动的神经炎症
Julia Konings,Fleur Mingneau,Serhii Chornyi et al.
Julia Konings et al.
In multiple sclerosis (MS), the chronic, unresolved nature of neuroinflammation within the central nervous system (CNS) remains a major obstacle for effective therapeutic intervention. This challenge arises primarily due to an incomplete un...
Improving T-cell engager efficacy in glioblastoma with multi-antigen targeting and novel delivery approaches [0.03%]
利用多抗原靶向和新型递送方法改善T细胞参与物在胶质母细胞瘤中的疗效
Arushi Tiwari,Kristen D Pawlowski,Irina V Balyasnikova
Arushi Tiwari
Glioblastoma remains a challenging disease to approach with immunotherapy due to pronounced antigen heterogeneity, immunosuppressive tumor microenvironment, and barriers to effective molecule delivery within the central nervous system. T-ce...
Mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE): genetics, mechanisms and precision therapy [0.03%]
癫痫中皮层发育轻度畸形伴少突胶质细胞增生（MOGHE）的遗传学、机制及精准治疗
James Spyrou,Paul J Lockhart,Snezana Maljevic et al.
James Spyrou et al.
Mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE) is a recently defined malformation of cortical development that is an important cause of childhood-onset drug-resistant epilepsy. Clinically, th...
Proteomic comparison of hippocampal neurofibrillary tangles in PART, intermediate Alzheimer's disease and advanced Alzheimer's disease [0.03%]
早老素1突变型和散发型帕金森病的血液蛋白质组学差异研究
Manon Thierry,Dominique Leitner,Kaleah Balcomb et al.
Manon Thierry et al.
Alzheimer's disease (AD) is characterised by the intraneuronal aggregation of phosphorylated Tau (pTau) into neurofibrillary tangles and by the extracellular deposition of β-amyloid (Aβ). Tau pathology restricted to the hippocampal format...
Comparative Study
Acta neuropathologica. 2026 Aug 1;152(1):13. DOI:10.1007/s00401-026-03064-9 2026
Retinal proteome changes mirror brain pathology and reveal synaptic and cytoskeletal dysfunction in Alzheimer's disease [0.03%]
视网膜蛋白质组变化反映了阿尔茨海默病的脑病理改变并揭示了突触和细胞骨架功能障碍
Jessica Santiago,Dovilė Pocevičiūtė,Teo Sällberg et al.
Jessica Santiago et al.
Visual dysfunction is increasingly recognized as an important feature of Alzheimer's disease, and substantial retinal changes have been documented across multiple studies. Yet the molecular changes underlying retinal neurodegeneration and w...
Aquaporin-4's dynamic expression and biological variations within the tumor obscure the paraneoplastic phenomenon in aquaporin-4-IgG-positive neuromyelitis optica spectrum disorder [0.03%]
肿瘤中 Aquaporin-4 的动态表达和生物学变异使自身免疫性视神经脊髓炎谱系疾病中的瘤周现象模糊化
Naga Pradyumna Kothapalli,Yong Guo,Nisa Vorasoot et al.
Naga Pradyumna Kothapalli et al.