Brachio-cervical inflammatory myopathy: multilevel clinical, histopathological and multi-omic analyses of a syndrome variably associated with systemic sclerosis [0.03%]
臂颈椎炎症性肌病：多水平的临床、组织病理和多种组学分析一种与系统性硬化症可变相关的综合征
Felix Kleefeld,Joanna Teran Gamboa,Iago Pinal-Fernandez et al.
Felix Kleefeld et al.
Brachio-cervical inflammatory myopathy (BCIM) is a rare and under-characterized subtype of idiopathic inflammatory myopathies (IIM), marked by prominent upper limb and neck muscle involvement. Since its initial description in 2006, few stud...
Multicenter Study
Acta neuropathologica. 2026 Apr 4;151(1):35. DOI:10.1007/s00401-026-03006-5 2026
Correction: Intracellular trafficking SNARE protein, syntaxin-6, modifies prion cellular phenotypes and risk of disease development in vivo [0.03%]
correction: 囊泡衔接蛋白syntaxin-6修饰细胞内小胶质细胞prion蛋白表型和致病风险
Elizabeth Hill,Mitali M Patel,Juan M Ribes et al.
Elizabeth Hill et al.
Published Erratum
Acta neuropathologica. 2026 Mar 30;151(1):34. DOI:10.1007/s00401-026-03003-8 2026
Correction: Alterations in glutamate receptor 2/3 subunits and amyloid precursor protein expression during the course of Alzheimer's disease and Lewy body variant [0.03%]
订正：阿尔茨海默病及路易体变异型病程中谷氨酸受体2/3亚单位和淀粉样前体蛋白表达的改变
Veronika Thorns,Margaret Mallory,Lawrence Hansen et al.
Veronika Thorns et al.
Published Erratum
Acta neuropathologica. 2026 Mar 30;151(1):33. DOI:10.1007/s00401-026-02997-5 2026
Preservation of miR-9-5p and miR-124-3p in ALS-resistant oculomotor neurons contrasts with their downregulation in vulnerable spinal motor neurons, irrespective of TDP-43 pathology [0.03%]
ALS抵抗性动眼神经元中miR-9-5p和miR-124-3p的保存与易损脊髓运动神经元中的其下调无关，无论是否有TDP-43病理改变
Crystal McLellan,Danae Campos-Melo,Robert Hammond et al.
Crystal McLellan et al.
Selective vulnerability of motor neurons is a defining feature of amyotrophic lateral sclerosis (ALS) and provides a valuable framework for uncovering mechanisms that distinguish resilient from vulnerable neuronal populations. We investigat...
Loss of oligodendrocyte transcription factor 2 protein expression in metabolically stressed oligodendrocytes [0.03%]
少突胶质细胞代谢压力下Olige因子2蛋白表达的丢失
Hannes Kaddatz,Lukas Wenzel,Emil Pril et al.
Hannes Kaddatz et al.
Oligodendrocytes are essential for myelin production, maintenance, and repair, and their dysfunction contributes to the pathogenesis of demyelinating diseases such as multiple sclerosis (MS). Here, we identify an early stress-associated oli...
Retraction Note: Neurotrophic effects of Cerebrolysin in the Mecp2308/Y transgenic model of Rett syndrome [0.03%]
撤回 notice: cerebrolysin 对雷特综合征的 mecprtp308/y 转基因模型的神经营养作用
Edith Doppler,Edward Rockenstein,Kiren Ubhi et al.
Edith Doppler et al.
Aberrant SOD1 aggregates in skeletal muscle target fibers in amyotrophic lateral sclerosis [0.03%]
肌萎缩侧索硬化症骨骼肌中异常的SOD1聚集物靶向纤维
Jieyu Li,Chao Gao,Qingqing Wang et al.
Jieyu Li et al.
Neuropathological measures of increased tau phosphorylation across the Down syndrome lifespan [0.03%]
唐氏综合症生命周期中tau过度磷酸化的神经病理学指标
Jesse R Pascual,Isabel Rivera,Halyma Nguyen et al.
Jesse R Pascual et al.
Individuals with Down syndrome (DS) have an increased risk of developing Alzheimer disease (AD), with nearly all individuals exhibiting AD neuropathology, including amyloid beta (Aβ) plaques and neurofibrillary tangles (NFT), by age 40 yea...
A distinct tau oligomer strain defines the molecular and proteomic landscape of rapidly progressive Alzheimer's disease [0.03%]
一种独特的tau寡聚体应激定义了快速进展型阿尔茨海默病的分子和蛋白质组景观
Tayyaba Saleem,Wiebke Möbius,Matthias Schmitz et al.
Tayyaba Saleem et al.
Rapidly progressive Alzheimer's disease (rpAD) is a rare subtype with rapid decline, but its molecular underpinnings remain poorly defined. Here, brain-derived tau oligomers (TauO) were systematically compared across nondemented controls, s...
TDP-43 impairs glycolysis by sequestering hexokinase 1 in amyotrophic lateral sclerosis [0.03%]
TDP-43通过在肌萎缩侧索硬化中捕获己糖激酶1来损害糖酵解
Cassandra Barone,Rihua Wang,Sarah Cooke et al.
Cassandra Barone et al.
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive motor neuron degeneration and cytoplasmic mislocalization of TDP-43. While metabolic dysfunction is increasingly recognized in ALS, the m...