Bioluminescence temporal signatures of monocyte differentiation reveals changes in phenotype due to GM-CSF, M-CSF, and PMA induction [0.03%]
单核细胞分化的生物发光时间特征揭示了GM-CSF、M-CSF和PMA诱导引起的表型变化
Zachary James,Colette Li,Anna Spassennikova et al.
Zachary James et al.
Human THP-1 monocyte-like cells are a commonly used model for monocyte-derived macrophages (MoDM) in vitro, and significant literature has demonstrated how MoDM phenotype depends on the type, concentration, and duration of differentiation s...
A synonymous NPR2 variant causes acromesomelic dysplasia through aberrant pre-mRNA splicing [0.03%]
同义NPR2变异通过前信使RNA剪接异常导致肢端胸骨段侏儒症
Nazli Busra Acikgoz,Hasan Basri Kılıç,Gizem Urel Demir et al.
Nazli Busra Acikgoz et al.
Precise regulation of pre-mRNA splicing is essential for normal development, and its disruption represents an important but frequently underrecognized mechanism of human disease. The C-type natriuretic peptide (CNP) receptor NPR2 is a criti...
Ovarian fibrosis in polycystic ovary syndrome: Mechanisms, evidences, and clinical implications [0.03%]
多囊卵巢综合征卵巢纤维化：机制、证据和临床意义
Sakshi Nalkande,Mrudula Patil,Kartik Nakhate et al.
Sakshi Nalkande et al.
Polycystic ovary syndrome (PCOS) is a complex heterogeneous endocrine disorder characterized by hyperandrogenism, ovulatory dysfunction, and polycystic ovarian morphology. Emerging studies suggest that ovarian fibrosis, as an underrecognize...
Palmatine enhances osteogenesis in hADMSCs via antioxidant enzyme upregulation and early RUNX2 activation [0.03%]
棕亭胺通过抗氧化酶上调和早期RUNX2激活增强人脂肪干细胞成骨分化
Tannaz Sakhavarz,Marzieh Ghollasi,Fereshteh Azedi et al.
Tannaz Sakhavarz et al.
Palmatine, a protoberberine alkaloid with recognized anti-inflammatory and anti-resorptive activities, has recently attracted interest as a potential modulator of bone homeostasis; however, its direct osteo-inductive effects on human adipos...
Direct Reciprocal Repression between Goosecoid and Ventx1.1 Modulates Dorsoventral Patterning in Xenopus [0.03%]
Goosecoid和Ventx1.1之间的直接互抑调节非洲爪蟾背腹轴模式化形成
Basant Kumar,Zobia Umair,Seung-Hwan Lee et al.
Basant Kumar et al.
Precise dorsoventral patterning in Xenopus embryos depends on coordinated transcriptional regulation between organizer and ventral genes. Goosecoid (Gsc) promotes dorsal identity, whereas Ventx1.1, a downstream effector of BMP signaling, sp...
Validated CRISPR/Cas9 guide RNAs targeting neurodevelopmental genes in the tunicate Ciona robusta [0.03%]
应用于曳鳃蛟(Ciona robusta)神经发育基因的经验证的CRISPR/Cas9向导RNA
Sydney Popsuj,Tenzin Kalsang,Kwantae Kim et al.
Sydney Popsuj et al.
The tunicate Ciona robusta provides a powerful and simplified model for dissecting the genetic control of developmental and cell biology. With a larval CNS composed of just over 200 neurons and sensory cells, it has also emerged as a model ...
Corrigendum to "Histone H2A deubiquitinase BAP1 is required for human neuronal progenitor cell formation" [Differentiation 149 (2026) 100957] [0.03%]
关于“组蛋白H2A去泛素化酶BAP1为人神经元祖细胞形成所必需”的校正公告(发表于《分化》杂志2026年第149卷100957页)
Dharitree Samal,Vaijayanti Kale,Prasad Pethe
Dharitree Samal
Luis Herrera,Luis Alfonso Arráez,Laura Flores et al.
Luis Herrera et al.
The prenatal structural organization of the human heel fat pad (HHFP) remains poorly understood, despite its relevance for foot development and related disorders. It is composed of neural, vascular, fibrous, and elastic components arranged ...
Bridging cells: Potential crosstalk between the peripheral and central olfactory sensory system [0.03%]
桥梁细胞：外周和中枢嗅觉感觉系统之间可能存在相互作用
Jorge Torres-Paz,Ricardo Ceriani,Kathleen E Whitlock
Jorge Torres-Paz
The olfactory sensory system in unique is that the first synaptic contact lies within the central nervous system meaning that the same olfactory sensory neuron whose dendrites are in contact with outside world, has axons extending directly ...
Osteoclast-derived DEL1 promotes pathological bone formation in ankylosing spondylitis by regulating RUNX2 expression in osteoblasts [0.03%]
软骨细胞衍生的DEL1通过调节破骨细胞促进骨关节炎病理进展
Seung Hoon Lee,Chanhyeok Jeon,Dongju Kim et al.
Seung Hoon Lee et al.
Background: Ankylosing spondylitis (AS) is a chronic inflammatory disease characterized by ectopic bone formation. We investigated in vitro and in vivo the role of developmental endothelial locus-1 (DEL1) on new bone form...