Ovarian fibrosis in polycystic ovary syndrome: Mechanisms, evidences, and clinical implications [0.03%]
多囊卵巢综合征卵巢纤维化：机制、证据和临床意义
Sakshi Nalkande,Mrudula Patil,Kartik Nakhate et al.
Sakshi Nalkande et al.
Polycystic ovary syndrome (PCOS) is a complex heterogeneous endocrine disorder characterized by hyperandrogenism, ovulatory dysfunction, and polycystic ovarian morphology. Emerging studies suggest that ovarian fibrosis, as an underrecognize...
Palmatine enhances osteogenesis in hADMSCs via antioxidant enzyme upregulation and early RUNX2 activation [0.03%]
棕亭胺通过抗氧化酶上调和早期RUNX2激活增强人脂肪干细胞成骨分化
Tannaz Sakhavarz,Marzieh Ghollasi,Fereshteh Azedi et al.
Tannaz Sakhavarz et al.
Palmatine, a protoberberine alkaloid with recognized anti-inflammatory and anti-resorptive activities, has recently attracted interest as a potential modulator of bone homeostasis; however, its direct osteo-inductive effects on human adipos...
Direct Reciprocal Repression between Goosecoid and Ventx1.1 Modulates Dorsoventral Patterning in Xenopus [0.03%]
Goosecoid和Ventx1.1之间的直接互抑调节非洲爪蟾背腹轴模式化形成
Basant Kumar,Zobia Umair,Seung-Hwan Lee et al.
Basant Kumar et al.
Precise dorsoventral patterning in Xenopus embryos depends on coordinated transcriptional regulation between organizer and ventral genes. Goosecoid (Gsc) promotes dorsal identity, whereas Ventx1.1, a downstream effector of BMP signaling, sp...
Validated CRISPR/Cas9 guide RNAs targeting neurodevelopmental genes in the tunicate Ciona robusta [0.03%]
应用于曳鳃蛟(Ciona robusta)神经发育基因的经验证的CRISPR/Cas9向导RNA
Sydney Popsuj,Tenzin Kalsang,Kwantae Kim et al.
Sydney Popsuj et al.
The tunicate Ciona robusta provides a powerful and simplified model for dissecting the genetic control of developmental and cell biology. With a larval CNS composed of just over 200 neurons and sensory cells, it has also emerged as a model ...
Corrigendum to "Histone H2A deubiquitinase BAP1 is required for human neuronal progenitor cell formation" [Differentiation 149 (2026) 100957] [0.03%]
关于“组蛋白H2A去泛素化酶BAP1为人神经元祖细胞形成所必需”的校正公告(发表于《分化》杂志2026年第149卷100957页)
Dharitree Samal,Vaijayanti Kale,Prasad Pethe
Dharitree Samal
Luis Herrera,Luis Alfonso Arráez,Laura Flores et al.
Luis Herrera et al.
The prenatal structural organization of the human heel fat pad (HHFP) remains poorly understood, despite its relevance for foot development and related disorders. It is composed of neural, vascular, fibrous, and elastic components arranged ...
Bridging cells: Potential crosstalk between the peripheral and central olfactory sensory system [0.03%]
桥梁细胞：外周和中枢嗅觉感觉系统之间可能存在相互作用
Jorge Torres-Paz,Ricardo Ceriani,Kathleen E Whitlock
Jorge Torres-Paz
The olfactory sensory system in unique is that the first synaptic contact lies within the central nervous system meaning that the same olfactory sensory neuron whose dendrites are in contact with outside world, has axons extending directly ...
Osteoclast-derived DEL1 promotes pathological bone formation in ankylosing spondylitis by regulating RUNX2 expression in osteoblasts [0.03%]
软骨细胞衍生的DEL1通过调节破骨细胞促进骨关节炎病理进展
Seung Hoon Lee,Chanhyeok Jeon,Dongju Kim et al.
Seung Hoon Lee et al.
Background: Ankylosing spondylitis (AS) is a chronic inflammatory disease characterized by ectopic bone formation. We investigated in vitro and in vivo the role of developmental endothelial locus-1 (DEL1) on new bone form...
Resveratrol modulates Hedgehog signaling pathway and increases the osteogenic commitment of periodontal ligament mesenchymal cells [0.03%]
白藜芦醇可通过调节牙周韧带间充质细胞中Hedgehog信号通路促进成骨分化
Rogério Salinas Ferreira,Rahyza Inácio Freire de Assis,Francesca Racca et al.
Rogério Salinas Ferreira et al.
Human periodontal ligament mesenchymal cells (PDLCs) are promising for regenerative therapies but show heterogeneous osteogenic commitment that limits bone regeneration. To attempt to overcome this limitation, we focus on the Hedgehog (Hh) ...
NNMT as a therapeutic target in fibrosis: Insights from the heart, liver, kidneys, and lungs [0.03%]
基于心、肝、肾和肺的纤维化研究探讨NNMT的治疗价值
Shi-Yan Lai,Xiang-Li Ni,Shuang-Zhou Bi et al.
Shi-Yan Lai et al.
Fibrosis, a key pathological process in chronic diseases, involves excessive extracellular matrix deposition that causes organ dysfunction. Due to the limitations of current therapies, identifying new treatment targets is essential. Nicotin...