Osteoclast-derived DEL1 promotes pathological bone formation in ankylosing spondylitis by regulating RUNX2 expression in osteoblasts [0.03%]
软骨细胞衍生的DEL1通过调节破骨细胞促进骨关节炎病理进展
Seung Hoon Lee,Chanhyeok Jeon,Dongju Kim et al.
Seung Hoon Lee et al.
Background: Ankylosing spondylitis (AS) is a chronic inflammatory disease characterized by ectopic bone formation. We investigated in vitro and in vivo the role of developmental endothelial locus-1 (DEL1) on new bone form...
Resveratrol modulates Hedgehog signaling pathway and increases the osteogenic commitment of periodontal ligament mesenchymal cells [0.03%]
白藜芦醇可通过调节牙周韧带间充质细胞中Hedgehog信号通路促进成骨分化
Rogério Salinas Ferreira,Rahyza Inácio Freire de Assis,Francesca Racca et al.
Rogério Salinas Ferreira et al.
Human periodontal ligament mesenchymal cells (PDLCs) are promising for regenerative therapies but show heterogeneous osteogenic commitment that limits bone regeneration. To attempt to overcome this limitation, we focus on the Hedgehog (Hh) ...
NNMT as a therapeutic target in fibrosis: Insights from the heart, liver, kidneys, and lungs [0.03%]
基于心、肝、肾和肺的纤维化研究探讨NNMT的治疗价值
Shi-Yan Lai,Xiang-Li Ni,Shuang-Zhou Bi et al.
Shi-Yan Lai et al.
Fibrosis, a key pathological process in chronic diseases, involves excessive extracellular matrix deposition that causes organ dysfunction. Due to the limitations of current therapies, identifying new treatment targets is essential. Nicotin...
Roles of the RNA-binding protein SRSF3 in development and cellular differentiation [0.03%]
RNA结合蛋白SRSF3在发育和细胞分化中的作用
Evan C Brooks,Charles W Griffin,Katherine A Fantauzzo
Evan C Brooks
RNA-binding proteins have been established as essential regulators of embryonic development, cellular differentiation and tissue homeostasis. In this review, we highlight the roles of the highly conserved serine/arginine-rich (SR) family me...
Histone H2A deubiquitinase BAP1 is required for human neuronal progenitor cell formation [0.03%]
组蛋白H2A去泛素酶BAP1是人类神经干细胞形成必需的
Dharitree Samal,Vaijayanti Kale,Prasad Pethe
Dharitree Samal
Formation of neuronal progenitor cells, neural crest cells and surface ectoderm cells is a complex process and differential gene expression allows for generation of these three cell types during neurulation process. Histone modifiers such a...
In vitro derivation of human brown adipose tissue from pluripotent and mesenchymal stem cell sources: A systematic review of genetic and non-genetic differentiation strategies [0.03%]
人棕色脂肪组织多能和间充质干细胞来源的体外分化：遗传及非遗传分化策略系统性回顾
Preethi Dharmendhran,Krishnakumar Subramanian,Sowmya Parameswaran
Preethi Dharmendhran
Human brown adipocytes (BAs) derived from stem cells are increasingly recognized as valuable in-vitro models for investigating thermogenesis and metabolic regulation. Despite this promise, existing differentiation strategies show wide varia...
Low and high osteogenic potential of periodontal ligament-derived mesenchymal stem cells correlates with RUNX2, SP7, EZH2 and KDM6B expression [0.03%]
牙周膜来源间充质干细胞低成骨和高成骨潜能与RUNX2、SP7、EZH2和KDM6B表达相关性研究
D C Andia,L F Oliveira,G S Feltran et al.
D C Andia et al.
Periodontal ligament-derived mesenchymal stem cells (PDLCs) possess selfrenewal and multilineage differentiation capacities, supporting their application in regenerative therapies. However, PDLCs are regulated by epigenetic mechanisms that ...
Ex vivo human cellular models to study adipocyte-induced transdifferentiation of osteoblasts [0.03%]
人骨髓间充质干细胞体外模型研究脂肪细胞诱导的成骨细胞向脂肪细胞转分化机制
Federica Quacquarelli,Damien Leterme,Véronique Gauthier et al.
Federica Quacquarelli et al.
In human, an association between bone loss and increased marrow adipose tissue suggests that medullary adipocytes could play a role in osteoporosis by acting on neighboring bone-forming osteoblasts. Supporting this hypothesis, we previously...
Comprehensive defect detection in mouse embryos and the heart by combining automated phenotyping with novel population averages and atlases [0.03%]
结合自动化表型分析与新型群体平均值和图谱实现小鼠胚胎及心脏的全面缺陷检测
Ella M M A Martin,Kyle Drover,Anton Shpak et al.
Ella M M A Martin et al.
Micro-CT has become the standard for the assessment of malformations in mouse embryos because it allows the visualisation of internal structures in the context of the intact embryo. Statistical comparison of volume differences is possible v...
Her9 is required for the migration, differentiation, and survival of neural crest cells [0.03%]
Her9对神经嵴细胞的迁移、分化和存活是必需的
Cagney E Coomer,Sumanth Manohar,Evelyn M Turnbaugh et al.
Cagney E Coomer et al.
Neural crest cells (NCC) are vertebrate-specific multipotent progenitor cells that arise from the neural plate border and go on to contribute to a wide variety of morphological structures such as the jaw and palate, enteric nervous system (...